Calcium tetacin

Calcium tetacin is an antidote substance.

The drug forms low-toxicity soluble combination bonds with rare earth and heavy metals, replacing Ca with metal ions, which create more stable compounds with it than calcium, and at the same time helps to excrete them with urine.

The drug does not interact with strontium, barium and other ions whose resistance constant is lower than calcium.

Indications Calcium tetacin

It is used in the active or chronic phase of intoxication (uranium, mercury, lead and cadmium, as well as yttrium, cobalt, cerium and thorium), and in addition to this, to eliminate lead-induced colic syndrome.

Release form

The medicine is released in the form of injection liquid, inside ampoules with a volume of 10 ml. Inside the box there are 10 such ampoules.

Pharmacokinetics

With intravenous injection, the distribution of the drug within the extracellular fluid occurs uniformly.

The half-life after intravenous injection is 20 minutes. Excretion with urine occurs in the form of chelate bonds, as well as in an unchanged state. After intravenous injection, excretion of lead chelates with urine occurs after 60 minutes. Maximum excretion is noted after 24-48 hours.

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Dosing and administration

The medication should be administered in a dose of 1 g/m2 ^- through a dropper, intravenously, 2 times a day. The medication is pre-dissolved in isotonic NaCl or 5% glucose (0.25-0.5 l).

Daily and single doses for intravenous injections are 4000 mg and 2000 mg (20 ml of 10% liquid), respectively. The drug is used daily for 3-4 days with a further 3-4-day interval. In case of 2-time use per day, it is necessary to observe at least a 3-hour break between procedures. The therapeutic cycle is 1 month.

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Use Calcium tetacin during pregnancy

There is only limited information regarding the use of calcium tetatsin during pregnancy and breastfeeding. There is no information confirming the effect of the drug on the incidence of congenital malformations or negative effects on the fetus.

Pregnant and lactating women are prescribed the drug only if strictly indicated.

Contraindications

Among the contraindications:

• nephrosis or nephritis;
• hepatitis in the active or chronic phase, accompanied by severe liver dysfunction.

Side effects Calcium tetacin

An increase in temperature may be observed, which causes fever, weakness and thirst. Sometimes vomiting, anemia, anorexia, nausea, lacrimation, myalgia and headaches appear, as well as dermatitis and swelling of the nasal mucosa.

At the initial stage of therapy, some patients experience a minor exacerbation of lead poisoning, in which pain in the limbs increases, the general condition worsens, and appetite is lost. The described symptoms disappear by the end of therapy.

Sometimes hemoglobin values decrease and the number of reticulocytes increases. A short-term decrease in the total Fe values in plasma and blood may be observed, which quickly increases after the end of drug use. Sometimes there is a decrease in blood cyanocobalamin values.

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Overdose

The use of large doses of the drug (50-60 g) can provoke a potentiation of negative symptoms, cerebral edema and toxic nephrosis.

The use of mannitol (to reduce cerebral edema), forced diuresis, and maintenance of vital organs are prescribed.

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Interactions with other drugs

The introduction of calcium tetacin in combination with iron substances and Zn-insulin weakens the effect of the latter.

Storage conditions

Calcium tetatsin should be stored in a dark place, out of the reach of small children. Temperature indicators are in the range of 15-25°C.

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Shelf life

Calcium tetacin can be used within a 5-year period from the date of manufacture of the therapeutic product.

Analogues

Analogues of the drug are the drugs Acizol and Protamine with Methionine.

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