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Omni
Last reviewed: 23.04.2024
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Omnik has α-adrenolytic effect.
Indications Omnika
It is used for therapy with dysuric disorders developing against the background of prostate adenoma.
Release form
Release of the medication is realized in capsules, in the amount of 10, 30 or 100 pieces inside the pack.
Pharmacodynamics
Tamsulosin is a substance from the category of drugs specifically blocking the activity of postsynaptic α1-adrenergic receptors located inside the smooth muscles of the prostate, the neck of the ureter and the prostatic section of the urethra. After blocking the activity of α1-adrenergic receptors under the influence of tamsulosin, there is a weakening of the tone of the muscles of the prostate, urethra and the prostatic area of the urethra, resulting in an improvement in urinary processes. Along with this, there is a decrease in the symptoms of filling and emptying of urea with prostate adenoma associated with detrusor hyperactivity and increased muscle tone of these organs.
The effect of tamsulosin on adrenoreceptors of the α1A subtype is 20 times stronger than that of the adrenoreceptors of the α1B subtype within the smooth muscle of the vessels. Due to this high selectivity, the use of tamsulosin does not cause a clinically significant decrease in the systemic values of blood pressure (and in individuals with normal blood pressure and in people with elevated indices), which allows prescribing hypertensive drugs.
Pharmacokinetics
Inside the intestine, the drug is absorbed fairly well, with almost 100% bioavailability. Admission along with food results in a slight slowing of drug absorption. An equal degree of absorption of the drug can be achieved by taking it every day after breakfast.
Tamsulosin has linear pharmacokinetic parameters. After a 1-time intake of the drug inside (0.4 mg), the Cmax level inside the plasma is observed after 6 hours. Regular daily intake of 0.4 mg of the substance already on the 5th day leads to the achievement of equilibrium values, which are approximately 2/3 higher than the level observed after a 1-time intake of the capsule. Protein synthesis inside the plasma is 99%, and the Vd value is about 0.2 l / kg.
Transformation of the drug under the influence of hepatic metabolism proceeds slowly enough; while less active metabolic products are formed. Most of the tamsulosin resides inside the blood plasma in the unmodified state.
Tests have shown that tamsulosin can weakly induce the activity of microsomal liver enzymes.
Tamsulosin, which remains unchanged in its unaltered state, is excreted through the kidneys together with its metabolic products. The half-life of a 1-fold oral dose (0.4 mg) of the drug after a meal is 10 hours. After reusable methods of drugs, these values reach 13 hours.
Dosing and administration
Capsules of the drug are consumed orally, immediately after the end of breakfast. The medicine should be washed down with plain water (0.1-0.2 l). During the day, take 400 μg of the substance (contained in the 1st capsule).
It is forbidden to chew capsules, because as a result, the release rate of the active ingredient of the medicament can be increased from them.
[2]
Contraindications
The main contraindications:
- presence of strong sensitivity to tamsulosin or other components of the drug;
- insufficiency of the liver, which has a severe form;
- orthostatic collapse (also available in history).
With caution, the drug is used in people with severe kidney diseases (CC level below 10 ml / minute).
Side effects Omnika
Use of the medication occasionally can lead to the emergence of certain side-effects:
- dizziness, development of orthostatic collapse, headaches;
- diarrhea, vomiting, or nausea and constipation;
- palpitation, tachycardia or asthenia;
- retrograde ejaculation;
- signs of intolerance (this includes angioedema, itching and eruptions on the epidermis).
[1]
Overdose
There is no information on acute intoxication with tamsulosin. In theory, when consuming very large portions of Omnik, there can be a sharp fall in the level of blood pressure, and with it a tachycardia of compensatory nature, in which it is required to perform symptomatic procedures.
The values of blood pressure and heart rate can be normalized after placing the patient in a horizontal position. If this method does not work, prescribe the use of drugs that increase the blood volume inside the vascular bed. If necessary, vasoconstrictor medicines may be used. In addition, during therapy, kidney function should be monitored. Sorbents can also be used and gastrointestinal cleaning (gastric lavage and consumption of laxatives).
Since tamsulosin binds heavily to the protein, hemodialysis procedures will be ineffective.
Interactions with other drugs
Combination of the drug with nifedipine, atenolol or enalapril does not lead to the development of any therapeutic interaction.
The combination with cimetidine causes a slight increase in plasma indices of tamsulosin, and in the case of admission with furosemide, a decrease in this value is observed. With such a medicamentous combination, the dosage of Omnik is not required to change, because the plasma level of its acting element remains within the limits of the norm.
Combination of a drug with diclofenac or warfarin can increase the rate of excretion of its active element.
Simultaneous use of α1-adrenergic receptors together with other antagonists can lead to a decrease in blood pressure.
Storage conditions
Shelf life
Omnic can be used within 4 years from the date of release of the therapeutic drug.
Analogues
The analogues of the medicine are medicines Dalfaz, Urerek, Alfirum with Alfuzozin, and besides Alfater, Dalfusin, Kornam with Setegis, and also Vezoni and Avodart.
Reviews
Omnik in most cases receives positive feedback, both from his patients, and from medical specialists. A large number of urologists recommend that men use this drug for prostate adenoma, prostatitis and other painful conditions, during which there are problems with the processes of urination. In these cases, tamsulosin, which has a relaxing effect on the muscles of the prostate, helps to eliminate the negative signs of the disease.
However, it should be noted that there are some negative comments about the drug. Often referred to as side effects, among which most often isolated pressure reduction and retrograde ejaculation.
Together with this it is necessary to take into account that in the treatment of prostate adenoma Omnik is used only to eliminate manifestations of the disease - it relieves of dysuric disorders. Therefore, for full-fledged therapy, it is necessary to use combined schemes that combine medications from different categories used in diseases of this type.
Attention!
To simplify the perception of information, this instruction for use of the drug "Omni" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.