Omitox

Omitox is a drug with antiulcer properties.

Indications Omitox

It is used to treat the following disorders:

• various forms of ulcerative diseases;
• gastrinoma;
• NSAID-associated disorders;
• GERD;
• lesions caused by the activity of the microbe Helicobacter pylori.

In addition, the medication is used to prevent the development of gastric pathologies.

Release form

The drug is released in the form of capsules with a volume of 10 or 20 mg. The box contains 30 such capsules.

Pharmacodynamics

The drug slows down the activity of the enzyme H ⁺ K ⁺ -ATPase inside the gastric parietal glandulocytes, as a result of which the final phase of hydrochloric acid binding is blocked. As a result, the rates of stimulated and basal secretion processes are reduced (it does not matter what the nature of the irritating bacteria is).

When taken once (orally), omeprazole begins to act after 60 minutes, and its effect lasts for 24 hours. The peak of effectiveness is noted after 2 hours from the moment of administration.

After stopping the use of the drug, excretory activity is fully restored after 3-5 days.

Pharmacokinetics

Omitox is absorbed from the gastrointestinal tract at a high rate, reaching the plasma Cmax level after 30-60 minutes. Bioavailability values are within 30-40%.

Protein synthesis rates are 90%. Almost all omeprazole undergoes metabolic processes within the liver.

Excretion of the substance occurs in the form of metabolic products, mainly through the kidneys.

Dosing and administration

The selection of the appropriate medicinal dose is carried out exclusively by a medical specialist. The capsules are swallowed whole, washed down with plain water.

During the treatment of an exacerbated intestinal ulcer, the medication is used in a dose of 20 mg with 1-time use per day. The therapy lasts 14 days, but if necessary, the course can be extended for another 14 days.

When treating an aggravated gastric ulcer or esophageal lesion of an inflammatory nature, the drug is taken at 20 mg per day, and this cycle lasts for 1 month.

In case of development of lesions caused by the use of NSAIDs, treatment with 20 mg of the substance per day is also continued for 1 month.

To get rid of the H.pylori microbe, the medication is taken in a dose of 40 mg per day for 7 days. Omitox must be prescribed in combination with antibacterial drugs.

To prevent ulcers, the drug is used in a dose of 10 mg per day. When preventing the development of GERD, the drug is prescribed in a dose of 20 mg per day. The treatment cycle in such cases is 0.5 years.

When treating gastrinoma, the dose is selected for each patient individually, but the course begins with a dosage of 60 mg. If necessary, it is increased to 120 mg. This dose should be taken in 2 doses.

People who have been diagnosed with liver dysfunction can be prescribed a maximum of 20 mg of the substance per day.

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Use Omitox during pregnancy

During pregnancy, taking Omitox is prohibited. If it is impossible to refuse such treatment, it is necessary to use some safer analogue.

Also, breastfeeding mothers should not use the medicine. If the use of the medicine is absolutely necessary, and the use of analogs is impossible, it is necessary to stop breastfeeding for the duration of therapy.

Contraindications

It is contraindicated to use the medication if you are allergic to any of its components.

Side effects Omitox

Taking capsules may cause side effects. Among them:

• vomiting, constipation, diarrhea, abdominal pain and nausea, as well as taste disorders, stomatitis, dry mouth and bloating. Jaundice and liver dysfunction also occur;
• encephalopathy, dizziness, depression (sometimes severe), headaches, hallucinations, paresthesia and a feeling of drowsiness;
• muscle weakness, myasthenia with myalgia and arthralgia;
• leukopenia or pancytopenia, and also agranulocytosis;
• bronchospasms, edema, urticaria, nephritis and anaphylaxis;
• alopecia, photosensitivity, erythema and itching;
• gynecomastia, hyperhidrosis, visual disturbances, cyst formation due to long-term therapy, and systemic ailments.

Doctors say that negative symptoms occur only occasionally and are transient.

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Overdose

In case of poisoning, tachycardia, agitation and arrhythmia are observed.

Symptomatic procedures are carried out to eliminate the disorders.

Interactions with other drugs

The combination with Omitox affects the bioavailability values of drugs whose absorption depends on pH values.

The drug is capable of inhibiting the elimination of certain drugs, the metabolic processes of which in the liver occur through the oxidation of microsomes (such as phenytoin with diazepam and indirect anticoagulants).

The absorption of ampicillin, ketoconazole and iron preparations is slowed when combined with the drug.

The drug may increase plasma levels of clarithromycin.

It is prohibited to consume alcoholic beverages while being treated with this drug.

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Storage conditions

Omitox should be stored in a dry, dark place, out of the reach of small children.

Shelf life

Omitox can be used within 36 months from the date of release of the therapeutic agent.

Application for children

It is not possible to prescribe medication in pediatrics.

Analogues

The following drugs are analogs of the drug: Losek, Omeprazole, Gastrozol, Omez with Omeprazole-Stada and Omeprazole-Richter, as well as Losek-maps (these drugs are considered the most effective). Analogs such as Ortanol and Tsisagast with Ultop are less effective.

Reviews

Omitox usually receives positive feedback from patients. Many note its high therapeutic effectiveness.

The advantages of the medication include its high speed of action - a noticeable improvement in the condition is noted after the first use. The positive aspects also include the cost of the medication - it is quite low.

But there are also comments that talk about the shortcomings of the drug. They mainly indicate that some patients developed side effects that were severe.