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Omez in erosive, atrophic and chronic gastritis
Last reviewed: 04.07.2025

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Gastritis is considered one of the most common diseases of the digestive system. Despite the multifactorial nature of this pathology, its pathogenesis comes down to the development of an inflammatory process in the stomach that prevents the normal functioning of the organ. And if acute gastritis (a rapidly progressing condition with its characteristic severe abdominal pain) is a temporary phenomenon, although extremely unpleasant, then the chronic form of the disease with its inherent relapses is already a "splinter" for life, which, moreover, can have unpleasant and dangerous consequences. Treatment of the pathology in any case should be comprehensive, and one of its important points is considered to be maintaining conditions in the stomach that help reduce the symptoms of inflammation. It is for this purpose that doctors prescribe "Omez" for gastritis, because control over the production of irritants in the stomach allows you to relieve the symptoms of acute and prevent relapses of chronic gastritis, regardless of the causes that caused the disease.
Indications Omeza for gastritis
According to the division into pharmacotherapeutic groups, "Omez" is one of the drugs for the treatment of peptic ulcers and gastroesophageal reflux disease. Most often, it is prescribed as part of a complex therapy for the following gastrointestinal diseases:
- Reflux esophagitis (inflammation of the walls of the esophagus, caused by the backflow of food from the stomach), especially its erosive-ulcerative form, when bleeding wounds form on the inflamed tissues of the esophagus.
- Peptic ulcer of the stomach and duodenum, i.e. the occurrence of wounds on the gastric mucosa caused by the increased secretory function of the organ, when the enzymes of gastric juice (and in particular pepsin) corrode the gastrointestinal tract's own tissues.
- Drug-induced ulcer, i.e. the process of destruction of cells of the gastric and intestinal mucosa under the influence of drugs (non-steroidal anti-inflammatory drugs NSAIDs are considered the most aggressive towards the delicate tissues of the stomach).
- Stomach ulcer caused by stress factors.
- Zollinger-Ellison syndrome is characterized by the formation of a tumor in the pancreas or duodenum that increases the production of a special hormone (gastrin), under the influence of which the synthesis of aggressive enzymes of gastric juice (pepsin and hydrochloric acid) is also enhanced.
Less frequently, Omez is prescribed to treat exacerbations of pancreatitis (inflammation of the pancreas), which results in increased load on other organs of the digestive system. Food flavored with gastric juice is retained in the stomach and provokes inflammation of its tissues. The drug is also used in the treatment of systemic mastocidosis (accumulation of mast cells in organs, provoking inflammatory processes that can also affect the digestive system, causing erosive and ulcerative processes in the stomach and intestines).
Among the many diseases in the treatment of which "Omez" or its analogue "Omeprazole" are used, there is no mention of a pathology characterized by inflammatory processes in the gastric mucosa. In this regard, a logical question arises: is it possible to use "Omez" for gastritis or is this drug not intended for the treatment of this pathology?
It seems a little strange that gastritis is not indicated at all in the indications for use of the drug, although there is a reference to the fact that the drug can be used to treat dyspeptic syndrome caused by increased acidity of the stomach. In fact, doctors prescribe Omez for gastritis no less often than for gastric ulcers and reflux disease with developing esophagitis (inflammation of the tissues of the esophagus).
The fact is that erosive and ulcerative processes usually develop against the background of tissue inflammation, which makes them more sensitive to various irritating factors, so taking Omez for inflammation of the gastric mucosa can prevent dangerous complications, including ulcers and stomach cancer.
Such a popular disease as gastritis can take on a variety of forms and progressions, so the advisability of taking a drug that reduces the production of gastric juice enzymes should be considered from the point of view of its benefits in treating a specific form of the disease.
Acute gastritis. The pathology is characterized by an active inflammatory process in the gastric mucosa, which causes severe pain and disrupts the normal functioning of the organ. Gastric enzymes have an aggressive effect, due to which food is digested. But if the stomach tissues are inflamed, these same enzymes will potentiate the inflammation and increase it, especially if they are produced in excessive quantities.
"Omez" is most relevant for gastritis with increased acidity of gastric juice, because it is the acid that acts as the main irritant for the mucous membrane in the absence of a bacterial factor. By reducing the production of hydrochloric acid and the aggressiveness of gastric juice, the drug thus removes the main factor that maintains the inflammatory process in the stomach.
And even if we are talking about Helicobacter pylori, for which the acidic environment of the stomach is the most comfortable, "Omez" is used as part of complex antimicrobial therapy. After all, the drug is capable of creating conditions unsuitable for the life and reproduction of bacteria, which weakens the pathogen and facilitates the work of antibiotics.
"Omez" can be prescribed to patients with superficial gastritis, which is considered the mildest form of the disease, since only the outer layers of the gastric mucosa are subject to inflammatory changes. The factor influencing the choice of drug in this case will be the increased acidity of the stomach.
In more severe forms of gastritis, for example, in erosive gastritis, "Omez" can be prescribed regardless of the acidity of the stomach, unlike antacids, which alkalize the gastric juice and are prescribed only at a low pH. The presence of erosions and ulcers on the mucous membrane complicates the course of gastritis too much, so you have to do everything so that they do not increase and heal quickly.
Low acidity of gastric juice is no less dangerous than high acidity. Reduced secretion of gastric juice leads to the fact that food is slowly digested in the stomach, and stagnation provokes irritation and inflammation of the mucous membrane. Low acidity also reduces immunity and is a favorable environment for the development of various bacteria, the products of whose vital activity also have an irritating effect on the tissues of the stomach, complicating the situation.
But how can Omez help in such a situation, and is there any point in taking a drug that further reduces the acidity of gastric juice? Oddly enough, doctors can prescribe Omez for low stomach acidity, but only to combat individual symptoms (heartburn, consequences of reflux). The course of treatment prescribed for high acidity is not applicable here.
Gastritis is a pathology that quite quickly becomes chronic with a characteristic recurrent course. In chronic gastritis, depending on the acidity of the stomach, Omez can be prescribed in courses or as symptomatic treatment. In any case, it reduces the severity of the inflammatory process and promotes the onset of remission.
During periods of remission and absence of constant discomfort, Omez can be taken as a means of combating heartburn and preventing relapses, and during exacerbation of gastritis - as a remedy that controls the pH of the stomach and thus protects the mucous membrane from additional irritation.
Atrophic gastritis is considered a special form of chronic pathology, which most often occurs against the background of decreased stomach acidity. The pathology is characterized by thinning of the gastric mucosa, as a result of which the number of glands producing gastric juice decreases. When the glands finally atrophy, the acidity of the stomach becomes zero and food cannot be digested without the introduction of special enzyme preparations. Moreover, atrophic gastritis is considered a precancerous condition.
The factor causing degenerative changes in the gastric mucosa is again the inflammatory process. When prescribing "Omez" for atrophic gastritis, doctors aim to reduce inflammation of the stomach tissues, which allows slowing down degenerative changes in them. However, no drugs can restore damaged cells.
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Release form
The drug "Omez" is an analogue of the domestic "Omeprazole" with the same active substance. The drug was developed by an Indian pharmaceutical company, and for some reason doctors liked it even more than the native drug.
The most popular and sought-after form of drug release is capsules, which most manufacturers produce in two colors. Inside the gelatin capsules you can find small white round granules, and on the lid and the top of the capsules you can see the inscription in the form of the name of the drug in English.
The active substance of "Omeza" is omeprazole, which is what we find inside the capsules, which include the excipients specified in the instructions. The capsule of the drug contains 10 or 20 mg of omeprazole.
Various modifications of this medicine can be found on sale today. For example, "Omez-D" is a complex drug, the active substances of which are omeprazole and the prokinetic domperidone, used to stimulate the digestive process. Both components are contained in capsules in a dosage of 10 mg.
"Omez-Dsr" is a combination drug of prolonged action with an increased dosage of both active substances, also produced in the form of capsules, which allows it to act at the right time in the right place. Each capsule of "Omeza-Dsr" contains a double dose of omeprazole (20 mg) and a triple dose of domperidone (30 mg).
Medicines containing omeprazole and domperidone have the same indications for use as simple "Omez", but in case of gastritis with low stomach acidity, their use will bring even more benefit, since domperidone will accelerate the movement of food through the digestive tract, stimulating contractile movements of the muscles of the stomach and duodenum. "Omez-D" and "Omez-DSR" can also be used as part of the complex treatment of atrophic gastritis. These medicines are considered effective in preventing stagnation in the gastrointestinal tract, which is considered a risk factor for the development and complications of inflammatory processes.
The domestic drug "Omeprazole", considered an analogue of the Indian "Omeza", is produced in the form of tablets and capsules with different dosages, while capsules are considered the most successful form, controlling the release of the active substance in the lower parts of the stomach and the area of its connection with the duodenum. The foreign manufacturer did not waste money on creating less effective forms, but also took into account the fact that the use of capsules is not suitable for everyone.
"Omez-Insta" is a version of a popular drug, released in the form of omeprazole powder with a dosage of 20 mg, placed in sachets (sochets). It is used to prepare a suspension for oral administration. The package contains from 5 to 30 sochets. This form of the drug is suitable for treating children and adults who have difficulty swallowing capsules. It is also better to use it in the treatment of atrophic gastritis instead of pre-dissolving the capsules of regular "Omez" in water.
Pharmacodynamics
After we have sorted out the possibilities of prescribing Omeza for gastritis and the forms of the drug, it is time to understand how this popular drug for the treatment of diseases of the digestive system works.
The pharmacodynamics of the drug is based on its ability to influence spontaneous and stimulated secretion of gastric juice. Omeprazole is considered a proton pump inhibitor. An inhibitor is a substance that suppresses the activity of others. The proton pump is called specific proteins (hydrogen-potassium adenosine triphosphatase) in the gastric mucosa, which regulate the transport of hydrogen and potassium ions. They are responsible for activating the production of hydrochloric acid.
Thus, the active substance of the drug "Omez" for gastritis reduces the activity of cells that produce hydrochloric acid, a decrease in the concentration of which leads to a decrease in the acidity of the gastric juice. This is good for the damaged mucosa, since it reduces its irritation.
But on the other hand, hydrochloric acid is simply necessary for active digestion of food, and its reduction may not have a very good effect on the functioning of the stomach if gastritis occurs against the background of normal or reduced acidity of gastric juice. This point prompted manufacturers to create modified forms of "Omeza", in which the second active substance is a prokinetic.
Prokinetics are substances that stimulate the motility of the gastrointestinal tract. Domperidone is an antagonist of dopamine receptors, which have antiemetic and stimulating effects. Thanks to it, the period of active contractions of the muscles of the esophagus, upper and lower parts of the stomach and duodenum is extended, which facilitates and accelerates the removal of food from the stomach, flavored with aggressive enzymes of gastric juice. Thanks to such training, the tone of the lower esophageal sphincter increases, which prevents the occurrence of such an unpleasant phenomenon as reflux, i.e. throwing food from the stomach into the esophagus.
The beneficial properties of "Omeza" and its combined analogues with the same name are considered to be the drug's help in the fight against Helicobacter pylori. The drug reduces stomach acidity and bacterial activity, which, in combination with taking antibacterial agents, allows you to quickly reduce the severity of gastritis symptoms, helps heal microdamage to the mucous membrane in its erosive-ulcerative variety, and promotes longer remission in the chronic course of the pathology.
Even with long-term treatment with the drug, there is no decrease in its activity, which allows, if necessary, to repeat the treatment courses of "Omeza" during exacerbation of gastritis several times a year.
Studies of patients with gastritis combined with reflux disease and esophagitis have shown a significant reduction in symptoms and frequency of reflux.
An unpleasant side effect, typical of all drugs that reduce stomach acidity, is the high probability of growth of opportunistic microorganisms that were previously present in the gastrointestinal tract in small quantities. Disruption of the body's microflora in turn increases the risk of all kinds of intestinal infections.
Pharmacokinetics
The proton pump inhibitor "Omez" and drugs with a combined composition have a noticeable speed of action. A decrease in the acidity of gastric juice is observed already within the first hour after oral administration of the drug, which indicates a rapid and good absorption of active substances in the gastrointestinal tract. The capsule shell protects the active substance from early activation under the influence of gastric juice. Omeprazole is absorbed in the lumen of the small intestine within 3-6 hours, from where it enters the blood. Already 1-2 hours after taking the drug, the concentration of omeprazole in the blood plasma reaches its maximum.
Simultaneous food intake does not affect the absorption and bioavailability of the drug, so tablets can be taken before, during or after meals. Drugs containing domperidone, the absorption of which slows down with a decrease in stomach acidity, are recommended to be taken before meals and with an interval between taking this drug and antacids or histamine receptor inhibitors prescribed for the treatment of gastritis with increased stomach acidity.
Both active substances do not accumulate in the body, although subsequent doses of the drug have a comparatively greater effect than the first. Neither omeprazole nor domperidone contribute to the induction of their own metabolism. These are corrective agents of temporary action.
In the vast majority of cases, Omez is prescribed for gastritis only once a day. This is enough to maintain stomach acidity at the appropriate level for 24 hours. A four-day course helps to temporarily stabilize the production of hydrochloric acid and reduce it by 70 percent or more when taken daily at a dosage of 20 mg.
The blocking of hydrochloric acid production by omeprazole, which is necessary to allow the gastric mucosa to recover, is reversible. Three days after the last dose of the drug, enzyme synthesis returns to its previous levels, and effective digestion of food occurs naturally.
The metabolism of the active substances of "Omeza" is carried out in the liver, and the kidneys and intestines are responsible for the excretion of metabolites. However, most of the metabolites are excreted in the urine.
Dosing and administration
In the instructions for the drug "Omez" you can find the method of application and dosage of the drug for the treatment of pathologies indicated in the indications for its use, so a logical question arises as to how to take the drug for gastritis, which may not be mentioned in the annotation.
An effective therapeutic dosage of the drug for the treatment of gastritis is considered to be 20 mg, although in the case of normal and reduced acidity of gastric juice, taking 10 mg of omeprazole once a day will be sufficient. The dose can be increased only as prescribed by a doctor in the absence of the desired effect.
Single-component "Omeprazole" is recommended to be taken before or during meals, although in case of atrophic gastritis the drug may be prescribed for taking 15-30 minutes after meals. Two-component drugs containing the prokinetic domperidone are recommended to be taken 15-30 minutes before meals.
Capsule preparations are taken without chewing, with a sufficient amount of liquid, but not milk or dairy products. If a person cannot swallow a capsule, it can be opened, the contents mixed with a small amount of water and citrus juice, and drunk. Dairy and carbonated drinks are not used for these purposes.
It is important to understand that the drug is not released in the form of gelatin capsules for nothing, which ensure the activation of the active substance not in the stomach, but in the intestinal lumen. If the capsule is opened, the effect of taking the drug may be less, since some of it will be destroyed by digestive enzymes. If it is impossible to swallow capsules, it is better to use a special form of "Omez-Insta".
The powder form requires preliminary preparation of the suspension, for which the contents of one sachet (20 mg of omeprazole) are mixed with two spoons of water. It is not necessary to wash down the medicine, but it is allowed to rinse the container in which the suspension was prepared with a small amount of water and drink this liquid.
The suspension should be taken one hour before meals, freshly prepared. The prepared suspension cannot be stored.
The amount of Omez to take for gastritis is determined by the attending physician, based on the form of gastritis, gastric acidity levels, and the patient's condition. The minimum effective course of Omez for gastritis is 4 days, but for the treatment of reflux and heartburn in pathology with low stomach acidity, the drug can be prescribed once to relieve unpleasant symptoms. In this case, a course of treatment can only worsen the situation with food digestion.
For gastritis with increased stomach acidity, the drug is usually prescribed in a course of one and a half to two weeks, although if necessary, the duration of the course of treatment can be increased, especially if the disease is combined with reflux esophagitis, the treatment of which can last for a period of 4-8 weeks.
For the treatment of gastritis associated with Helicobacter pylori, the drug is prescribed as part of 2-3-4 component regimens of irradiation of the bacteria in combination with antibiotics. In this case, the dosage of the drug and the duration of the course of treatment depend on the prescribed regimen. Thus, "Omez" can be taken twice a day at 20 mg in combination with amoxicillin (1 g 2 times a day) or a combination of clarithromycin and metronidazole. The duration of treatment in different irradiation regimens can vary from 7 to 14 days.
Use for children. "Omez" is not considered an absolutely safe drug for children, therefore, for gastritis, it is prescribed only from the age of 12. At an earlier age, the drug can be used only for the treatment of reflux disease (from 2 years) and gastric ulcer and duodenal ulcer (from 4 years), although there is information about the appointment of a short course of treatment for reflux in infants. There is no information that taking "Omez" can have a negative effect on the growth, development and sexual maturation of a child.
Use Omeza for gastritis during pregnancy
The use of the drug during pregnancy is not prohibited, but it is not very encouraged either. The fact is that animal studies have shown some negative effects of the drug on the fetus, but such experiments have not been conducted on pregnant women for obvious reasons. And since there is no talk of serious consequences for the child, doctors prescribe the drug to expectant mothers if the disease and its symptoms pose a danger to the life and health of the woman that exceeds the risk to the baby. It is impossible to independently decide on taking Omez and especially its combined analogues during this period.
When breastfeeding, a woman will have to choose: either take the drug or breastfeed the child. The fact is that omeprazole can penetrate into breast milk, which can negatively affect the functioning of the baby's digestive tract. In addition, the baby's body may not react as favorably to the components of the drug as the mother's body.
Combination drugs are not recommended for use during pregnancy and lactation. They are prescribed for children aged 12 years and older.
Contraindications
"Omez" is a drug with proven effectiveness, which has been used for many years in the treatment of gastritis, stomach ulcers, reflux disease and some other gastrointestinal diseases. But this does not mean that the drug has no contraindications for use, so before you buy and start taking the drug, you should read the above-mentioned paragraph of the instructions.
The main contraindication to taking Omez and its combined analogues is considered to be increased sensitivity of the patient's body to the main or auxiliary substances of the dosage form. Preparations containing domperidone in addition to omeprazole are not prescribed for mechanical intestinal obstruction, gastrointestinal bleeding, damage to the walls of the stomach and intestines, when stimulation of the motor activity of the organ walls can complicate the situation.
Other contraindications include: the presence of a tumor in the pituitary gland caused by prolactin, prolongation of cardiac conduction intervals in various heart diseases, serious electrolyte imbalances, severe liver and kidney pathologies with impaired functionality.
Powder for preparation of oral suspension is not prescribed for hereditary disorders of glucose metabolism and metabolic alkalosis.
When conducting antiretroviral therapy, it must be taken into account that the drugs used in this case are not compatible with omeprazole.
Caution should be exercised when treating with Omez in patients with liver and kidney diseases, since the metabolism and excretion of the drug is carried out by these organs.
Side effects Omeza for gastritis
"Omez" is considered one of those drugs that are well tolerated by most patients, which explains the high popularity of this drug. However, doctors do not rule out the occurrence of some side effects.
Most often, when taking Omez for gastritis or other gastrointestinal pathologies, patients complain of headaches, epigastric pain, bowel disorders (usually constipation, less often diarrhea), flatulence, nausea and vomiting. It is believed that these symptoms may be associated with drug therapy, although it should be understood that they are also characteristic of most pathologies for which Omez is prescribed.
"Omez" and its combined analogues can negatively affect the appetite of patients, change the perception of the taste of food, provoke intestinal spasms. Taking drugs can occasionally change the composition of the blood, which is diagnosed as leukopenia, agranulocytosis and some other violations of hematological parameters.
Hypersensitivity reactions to the drug and anaphylaxis are also very rare.
Long-term use of Omez may negatively affect the body's sodium and magnesium levels, causing hypokalemia or hypomagnesemia. The latter manifests itself in the form of increased fatigue, convulsions, and fainting.
There have also been rare reports of insomnia, increased sleepiness, dizziness, and impaired body sensitivity while taking the drug, and even rarer reports of depression or hallucinations.
Blurred vision, tinnitus, bronchospasm, hepatitis or kidney dysfunction symptoms, skin or skeletal reactions are also considered rare side effects.
Long-term use of proton pump inhibitors can result in the formation of glandular cysts in the stomach. These are benign neoplasms that disappear on their own after discontinuing the drugs that reduce the acidity of gastric juice.
Overdose
For gastritis, Omez is usually prescribed in a dosage of 20 mg per day. To combat Helicobacter pylori, the dosage can be increased to 40 mg or more. In the absence of allergic reactions, these doses are considered absolutely safe for people who have no contraindications to the use of the drug.
Neither omeprazole nor domperidone accumulate in the body, so overdose due to long-term drug use is excluded. All negative effects are not associated with intoxication of the body, but with disorders caused by insufficient amounts of hydrochloric acid involved in the digestion process.
Overdose symptoms in studies appeared only after a single oral dose exceeding the recommended dose by 100-120 times. In this case, patients complained of headaches, epigastric discomfort, diarrhea, nausea, vomiting, described in the paragraph on side effects of "Omeza". Even with such high doses, confusion, apathy and depression were noted only in isolated cases.
All overdose symptoms are short-lived and not life-threatening for patients. Symptomatic treatment can be administered if necessary.
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Interactions with other drugs
"Omez" for gastritis is often prescribed as part of a complex therapy, when it is necessary to take other drugs of different groups together with it. In addition, many patients have other diseases in addition to gastritis, for the treatment of which they again have to take certain drugs. In these cases, it is very important to take into account the interaction of drugs, because omeprazole, as a proton pump inhibitor, reduces stomach acidity, which can disrupt the usual absorption of oral drugs.
Thus, the absorption of oral antifungal agents containing posa-, keto- or intraconazole, as well as a drug for the treatment of large-cell cancer of the internal organs called "Erlotinib" will also decrease with a decrease in stomach acidity. But "Digoxin" (a cardiac glycoside used to treat heart failure) will behave differently. Its absorption increases by an average of 10 percent, which is considered harmless, but with an increase of 30 percent or more, toxic effects were noted.
Medicines for the treatment of retroviral infection, the active substances of which are nelfinavir and atazanavir, are poorly combined with "Omez", the active substance of which reduces the content of these components in the patient's blood, which means that the effect of taking the drugs will be significantly lower. Simultaneous administration of omeprazole and nelfinavir is contraindicated, since the effectiveness of the latter is reduced by more than half regardless of the dose. But the interaction with atazanavir is dose-dependent. In this case, in order to achieve a more or less good antiviral effect, it is necessary to reduce the dose of omeprazole and increase the dosage of the antiretroviral drug, which is also not considered the best option.
Other antiretroviral drugs may behave differently in combination with omeprazole. Thus, the concentration of sanquinavir in the blood may increase, and some other drugs do not react to changes in stomach acidity.
"Omez" negatively affects the absorption of the antiplatelet drug "Clopidogrel" in the gastrointestinal tract. This combination leads to a decrease in the duration of action of the drug and a decrease in the therapeutic effect, which consists in reducing platelet aggregation, which is the reason for the requirement to avoid such treatment regimens.
Omeprazole is considered an inhibitor of the enzyme CYP2C19. Concomitant administration of drugs whose metabolism occurs with the participation of the same enzyme (for example, Diazepam, Warfarin, Phenytoin, Cilastazol, etc.) can inhibit metabolism and increase the time the drug remains in the patient's body.
In this regard, when simultaneously prescribing Omeza and the above-mentioned drugs, it is recommended to monitor the dose of drugs in the body and, if necessary, reduce it.
The immunosuppressant drug "Tacrolimus, which prevents rejection of implants of vital internal organs, is also excreted from the body more slowly under the influence of omeprazole, which leads to an increase in its concentration in the blood and a negative effect on kidney function. Simultaneous administration of such drugs requires monitoring the level of the immunosuppressant in the blood and, if necessary, reducing its dosage.
Caution should be exercised and, if necessary, the antitumor drug "Methotrexate" should be taken. In this case, it is better to refuse to take "Omez" and its analogues.
Omeprazole is metabolized in the liver with the participation of another enzyme - CYP3A4, although it does not reduce its activity. However, other drugs that can inhibit this enzyme or both enzymes involved in the metabolism of omeprazole (these include the antibiotic clarithromycin and the antifungal agent voriconazole), when taken simultaneously with Omez, increase the level of its active substance in the blood plasma. An overdose of omeprazole in this case is unlikely, but for patients with severe liver disease, it would not be superfluous to adjust its dose.
Drugs that can enhance the action of enzymes that metabolize omeprazole (for example, the antibiotic rifampicin and St. John's wort) accelerate the metabolism of omeprazole, as a result of which its concentration in the blood can quickly decrease and the effect of the drug will not be as effective and long-lasting.
In the case of exacerbation of gastritis with increased acidity, if the symptoms of the disease are especially pronounced, doctors often resort to a treatment regimen that involves taking two drugs that affect the acidity of the stomach: a proton pump inhibitor based on omeprazole and a bismuth drug (for example, the widely advertised "De-Nol"). Both drugs are designed to protect the diseased mucous membrane of the stomach and duodenum, but they act in completely different ways. "De-Nol" forms a protective film on the surface of the mucous membrane, which can prevent the absorption of other oral agents.
"Omez" and "De-nol" for gastritis are quite acceptable to take simultaneously, but the absorption of omeprazole will be somewhat lower. In the therapeutic regimens recommended by doctors, the drugs should be taken at intervals of approximately an hour and a half. Ideally, one drug can be taken half an hour before a meal, and the other half an hour to an hour after a meal.
In the preparations "Omez D" and "Omez DSR", prescribed for gastritis, it is necessary to take into account the drug interaction of domperidone. The action of this substance can be reduced to "nothing" by anticholinergic agents. Antacids and antisecretory agents significantly reduce its absorption in the intestine.
Inhibitors of the CYP3A4 enzyme, which is involved in the metabolism of both active substances, increase the concentration of domperidone in the blood and lead to prolongation of the QT interval on the cardiogram. Strong inhibitors of this enzyme in combination with domperidone can worsen the condition of patients with a weak heart, so such interactions should be excluded. The drug "Omez", enriched with a prokinetic, is prohibited to combine with azole antifungal drugs, macrolides, protease inhibitors, including antiretroviral therapy, calcium antagonists and some other drugs.
Domperidone enhances the effect of neuroleptics and reduces the severity of side effects of dopamine antagonists. In any case, before starting treatment with a single-component drug or its combined analogue, you should consult a doctor about the interaction of these drugs with other drugs that the patient has to take.
Storage conditions
Special instructions
In order for treatment with Omez to be more effective, you should not take this drug and other drugs that reduce the acidity of gastric juice at the same time. Such drugs should be taken at intervals of at least 1 hour. At the same time, you should not prescribe medications to yourself just because you have increased stomach acidity. A strong decrease in gastric acidity can cause stagnation in the stomach associated with slow digestion of food, thus, inadequate treatment of gastritis can be harmful to the patient.
Before taking Omez for gastritis, you need to rule out the possibility of a malignant process in the gastrointestinal tract. Omeprazole and domperidone themselves will not affect cancer cells in any way, but they can mask the symptoms of a disease (for example, stomach cancer), which in advanced stages is deadly.
Patients with severe liver dysfunction should not be prescribed the drug with domperidone or the recommended doses will have to be reduced.
Long-term use of proton pump inhibitors or combined treatment with Digoxin may lead to the development of hypomagnesemia, so such patients should have regular monitoring of magnesium levels in the body.
Analogues
The Indian-made drug "Omez" is not the only representative of proton pump inhibitors. Similar properties are possessed by all drugs, the active substances of which are omeprazole, rabeprazole, lansoprazole, pantoprazole and other proton pump blockers. On pharmacy shelves you can find many popular and new drugs of this class: Russian "Omeprazole", Indian "Omitox", Swedish "Nexium", drugs "Emanera" and "Nolpaza" made in Slovenia, "Pantoprazole" made in China, etc.
Be that as it may, the most popular drugs among proton pump inhibitors prescribed for gastritis are still "Omez" and "Omerpazole", which doctors prescribe most often. It is very difficult to answer the question directly, which is better, because despite the fact that the drugs are complete analogues in terms of the active substance, they may differ in auxiliary components. The Russian drug contains substances that reduce the likelihood of allergic reactions, but when treating with an Indian drug of the same form of release, other side effects occur less often. And, of course, there is a difference in price. Foreign drugs always have a higher price compared to analogues produced in the countries of the former CIS.
The drug "De-nol", prescribed by doctors instead of or together with proton pump inhibitors, although it has a similar effect (refers to antisecretory agents, protects the mucous membrane and promotes its restoration), is not an analogue of "Omez". This drug increases the synthesis of enzymes that increase the pH of the stomach and forms a protective film on the surface of the mucous membrane.
A big plus of the drug "De-Nol" is its bactericidal activity against Helicobacter pylori. Therefore, when it comes to fighting this pest, the drug of choice is still "De-Nol". But despite all the effectiveness attributed to this drug, it is not able to destroy Helicobacter on its own forever, therefore "De-Nol", like "Omez", is prescribed as part of the schemes of irrationalization of bacteria using antibiotics.
Reviews
It is no secret that gastroenterologists who treat diseases of the digestive system regard proton pump inhibitors as effective drugs for stomach ulcers, reflux esophagitis and gastritis, helping to keep stomach acidity in check. Thanks to the action of Omez and its analogues, the inflammatory process is stopped and microdamage to the mucous membrane of the stomach and intestines is healed faster and more effectively, which makes it possible to accelerate the onset of remission in chronic gastritis.
Doctors' love for Omez can also be justified by the fact that this drug relatively rarely causes side effects that force patients to change their medication.
Reviews of those who took Omez for gastritis are not as rosy as the opinion of doctors. However, almost all patients agree that this is one of the best drugs that help cope with such an unpleasant symptom as heartburn. But heartburn is one of the manifestations of increased acidity of the stomach. If heartburn disappears, it means that the acidity of the organ has returned to normal.
Negative reviews, if they can be called such, indicate not so much the ineffectiveness of the drug, but rather the excessive demands on it. Acute symptoms of gastritis against the background of taking "Omez", despite the rapid action of the drug, go away in 4-5 days. It is clear that in order for the inflammatory process to subside, a single dose of the drug is not enough, which is not understood by all patients.
In addition, omeprazole belongs to the category of proton pump blockers, which affect stomach acidity indirectly, unlike antacids, which quench acid when directly entering the stomach. It is clear that antacids will help relieve heartburn faster than other antisecretory agents, but they are not able to correct the production of enzymes that negatively affect the gastric mucosa.
If there are such patients who hoped that Omez would cure chronic gastritis (and is it even possible?). This is a big mistake, because this drug is more of a preventive measure that reduces the likelihood of remission of the inflammatory process. In the case of chronic pathology, it has to be taken in courses for a long time.
You shouldn't count on getting rid of Helicobacter pylori with Omez either. The drug helps antibiotics actively fight the bacteria that cause gastritis and stomach ulcers, but it does not have bactericidal properties. If you don't see any improvements when taking Omez for gastritis, you should think about whether there is a "tenant" in your stomach that does not allow the inflammation to subside. In most cases of lack of effect from omeprazole and other proton pump inhibitors, special studies reveal the presence of the infamous Helicobacter in the stomach.
There are also reviews that indicate that the drug could not completely get rid of heartburn and other manifestations of increased acidity of gastric juice. The reason for this may be the same Helicobacter pylori, which irritates the gastric mucosa and its receptors, stimulating the production of hydrochloric acid and pepsin (and omeprazole is not a substance with antimicrobial activity). There is also such a possibility that the acidity of the stomach is very high and an increase in the dose of the drug is required (most often in such cases, "Omez" is prescribed in combination with other antisecretory agents).
As we can see, in the case of the absence or weakness of the effect, the reason for this in most cases is not the uselessness of the drug for the treatment of a specific pathology, but the insufficient examination of the patient or a lack of understanding of the principle of the drug's action. It is not surprising that in the absence of antibiotic therapy, "Omez" does not really help patients whose gastritis is provoked by bacteria, and it is not quite suitable for quickly relieving heartburn (antacids are more effective in this case).
In general, Omez shows good results for gastritis if taken as prescribed by a doctor and sensibly. It is especially helpful for those with increased stomach acidity, which is likely to lead to the formation of ulcers on the organ mucosa. Such drugs as Omez and Omeprazole help to avoid such unpleasant and dangerous consequences, even if their effect is not always noticeable from the outside.
Attention!
To simplify the perception of information, this instruction for use of the drug "Omez in erosive, atrophic and chronic gastritis" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.