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Omesin
Last reviewed: 23.04.2024
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Omesin is a medicament used in the treatment of GERD and various ulcerative lesions. Included in the category of drugs that slow down the activity of the proton pump.
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Indications of the omesina
It is used to eliminate such violations:
- ulcers in the gastrointestinal tract, as well as GERD;
- functional dyspepsia;
- a hyperacid form of gastritis having a chronic stage (in the exacerbation phase);
- destruction of H. Pylori (combined with other antibacterial medicines);
- gastrinoma.
Release form
Release of the medicine occurs in capsules with a volume of 20 mg, 10 pieces inside the strip. The box contains 1, 3 or 10 such strips.
Pharmacodynamics
The drug has antiulcer, as well as antisecretory properties, slows the activity of N / K-ATPase (proton pump). Has a blocking effect on the final stage of the release of hydrochloric acid inside the parietal glandulocytes, and in addition it slows down the stimulation with the help of pentagastrin or basal secretion.
Due to a significant and prolonged decrease in the level of gastric pH, ulcerous lesions heal much faster.
Pharmacokinetics
The medicament taken inside is fully and at high speed absorbed. About 90-95% of drugs are synthesized within the blood plasma with its protein. The drug effect persists for a minimum of 24 hours.
Excretion of metabolic products of the substance is carried out through the kidneys.
Dosing and administration
Omesin is prescribed for oral use by adults and adolescents from 12 years of age:
- with gastric ulcers (the heliobacter pylori bacteria is absent) - taking the first capsule twice a day, for 0.5-1.5 months;
- with ulcers in the intestine (H.pylori absent) - application of the 1st capsule twice a day, during the 0.5-1 month;
- in the treatment of GERD - apply 1-well capsule twice a day, for 1-2 months. At the same time, maintenance treatment includes taking the 1st capsule once a day during the first year;
- at a chronic stage of a hyperacid gastritis (a phase of an exacerbation) - the use of 1-2 capsules LS for a day during 2-3 weeks;
- with the elimination of functional dyspepsia - apply for a day for 1-2 capsules, for 2-3 weeks;
- to destroy the bacterium H.pylori - the use of the first capsule twice a day (in combination with antibacterial drugs (such as tetracycline and amoxicillin with metronidazole, clarithromycin and furozolidone), and in addition with bismuth drugs);
- when treating gastrinomas - the size of the initial portion is 3 capsules per day. If necessary, in the future, the dosage is increased. In general, the sizes of portions are selected individually for each person.
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Use of the omesina during pregnancy
Prescribe Omesin to pregnant women is not allowed.
Contraindications
The main contraindications:
- presence of severe intolerance with regard to medicinal elements;
- lactation period.
Side effects of the omesina
If the medicine is used for a short period of time, the side effects develop only occasionally. Moreover, they often have a weak degree of severity and are short in time. Severe forms of violations are observed only sporadically.
Among the negative reactions:
- Dermal lesions: occasionally there is an itch or a rash. Perhaps the development of alopecia, polyiform erythema or photosensitivity;
- violations affecting the work of the ODA: there may be pain in the area of muscles or joints, as well as weakness in the muscles;
- disorders of the function of the PNS or CNS: headaches. Occasionally there are paresthesias, vertigo, insomnia, dizziness and a feeling of drowsiness. Perhaps the development of hallucinations, depression, feelings of excitement and curable confusion of consciousness;
- problems with digestive activity: constipation, vomiting, bloating, abdominal pain, diarrhea and nausea. Perhaps the development of stomatitis or candidiasis in the gastrointestinal tract, as well as the dryness of the oral mucosa;
- lesions of the liver: the importance of hepatic enzymes occasionally increases. Possible development of hepatitis or encephalopathy (if severe forms of hepatic diseases are noted);
- disruption of the endocrine system: sometimes gynecomastia develops;
- disorders of hematopoietic functions: sometimes there is thrombocyto-, pancito- or leukopenia, as well as agranulocytosis;
- others: occasionally there is a feeling of general weakness;
- signs of allergy: occasionally develops urticarious rashes. Possible the appearance of bronchial spasms, anaphylaxis, angioedema, fever and tubulointerstitial nephritis. Also sometimes visual fuzziness, hyperhidrosis and a taste disorder develop, peripheral puffiness appears and the level of sodium inside the blood decreases.
Overdose
Omeprazole in a dose of 360 mg has an excellent tolerability. The drug has no antidote, and with the help of dialysis is excreted weakly, because the substance is synthesized with the protein of the blood plasma. Therefore, intoxication should be performed gastrointestinal lavage, and in addition to support and symptomatic activities.
Interactions with other drugs
The drug can interact with medications that are metabolized inside the liver with the help of hemoprotein 450 enzymes. When combined with Omese, it is possible to increase the values of phenytoin, disulfiram, and in addition aminopyrine with diazepam, warfarin and nifedipine. Usually, if omeprazole is taken in recommended portions, this increase is not of medicinal significance, but it is necessary to monitor the patient's condition at the initial stage of therapy and after it, correcting, if necessary, the dose of drugs.
Combination of the drug with clarithromycin can lead to a simultaneous increase in their indices inside the blood plasma.
Due to low values of gastric pH, the absorption of ketoconazole with ampicillin and iron drugs may change.
Combined use of medication with amoxicillin, lidocaine, antacids, metoprolol, and besides quinidine, theophylline and digoxin does not lead to the development of any drug-significant interactions.
Storage conditions
Omega should be kept in a place that is closed from sunlight, penetration of moisture, and access of young children. Temperature marks - within the limits of 8-25 ° С.
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Shelf life
Application for children
The medicine is used for children over the age of 12 years.
Analogues
Analogues of the drug are medicines Diaprazole, Gasec-10, Lorsec and Domstal-O, as well as Limzer, Loseprazol, Losid-20 and Losek, and in addition Omelox, Ozol with Omelik and Omep. The list also includes Omez (Omez DSR and Omez D), Omeprazid, Oprazole with Omenax, and in addition Omeprazole (different forms of medicine), Osid with Ultop and Proton with Ortanol.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Omesin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.