Olatropil enhances the properties of antidepressants, which is especially important for people resistant to typical / atypical antidepressants. The drug also reduces the side effects of tranquilizers, antipsychotics and hypnotic drugs.
Combined use with alcoholic beverages does not affect the serum indices of the drug. The serum level of alcohol does not change if you use 1.6 g of piracetam.
Combination with thyroid hormones (T3 + T4) can cause severe irritability, sleep disorders and a state of disorientation.
The interaction of piracetam with phenytoin, clonazepam, sodium valproate, and phenobarbital was not detected. In the case of 20 mg pyracetam per day, the level of AUC and the peak value of the above medicines in epileptics does not change.
In patients with severe thrombosis in a recurring form, piracetam in high doses (per day 9.6 g) had no effect on the dose of acetocumarol to produce an INR of 2.5-3.5. Although in the case of combined administration, there was a strong decrease in the values of the adhesion of platelets, and in addition blood and plasma viscosity, as well as the indices of fibrinogen and vWF.
The likelihood that the pharmacodynamic properties of pyracetam will change under the influence of other drugs is rather low, since 90% of the substance is excreted unchanged together with the urine.
It is also unlikely that the metabolic interaction of piracetam with drugs, the exchange of which occurs with the participation of the following isoforms of hemoprotein P450. This is known, because in vitro tests showed that at 142 and 426, and 1422 μg / ml, the effective component of Olatropyl does not affect the effectiveness of elements such as CYP1A2 with 2B6, and in addition 2C8 and 2C9 with 2C19, as well as 2D6 , 2E1 and 4A9 / 11. At a dosage of 1422 μg / ml, the component slightly inhibits the action of the CYP2A6 isoforms, as well as of the ZA4 / 5 (21% and 11%, respectively), but the K and 2 CYP isomers remain at the required level.
In the case of combination with drugs from the category of benzodiazepines (such as antiepileptic drugs and tranquilizers), and in addition to sedatives (such as barbiturates), there is a mutual increase in efficacy. When combined with benzodiazepines, each medication should be taken in medium or minimal effective dosages.
Pyridoxine hydrochloride is capable of enhancing the properties of olatropyl.