Nyz

Nayz is a medicine with analgesic, antipyretic, antiaggregant, and anti-inflammatory properties.

Indications Nyz

Indications for the use of this drug are such diseases: osteoarthritis or osteoarthritis, and in addition tendosynovitis, inflammation of the tendons, bursitis, ankylosing spondylitis, rheumatism. Also for pain in the muscles and spine, pains that occur after injuries, various infections and inflammations, neuralgia and fevers.

The Nyz gel is used to treat inflammation or degenerative processes in the ODA, a psoriatic or rheumatoid arthritis that develops as a result of exacerbated rheumatism or articular arthrosis, and in addition radiculitis. Also with lumbago, osteochondrosis accompanied by radiculopathy, and in addition with sciatica, as well as inflammation of ligaments or tendons.

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Release form

Produced in the form of tablets with a volume of 100 mg, orally dispersible tablets of 50 mg, and in addition an oral suspension of 50 mg / 5 ml and 1% gel.

Pharmacodynamics

The drug depresses the formation of PG in the inflammatory focus, and selectively slows down COX2. Occasionally, due to suppression of the synthesis of PG within healthy tissues, side reactions may occur. Inhibits peroxide lipid oxidation, without affecting the processes of hemostasis with phagocytosis.

The gel has local analgesic and anti-inflammatory properties. It helps to ease or eliminate the pain that arises in the joints in a state of rest or movement. Also, swelling with joint stiffness is eliminated in the morning.

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Pharmacokinetics

After oral administration, the drug is rapidly absorbed from the digestive tract. The peak concentration reaches 1.5-2.5 hours after the use of the tablet. Half-life lasts 3 hours. The main product of decomposition is active hydroxynimidesulide. Biotransformation of the medicine occurs in the liver, and its excretion is mainly through the kidneys. With prolonged use, it does not accumulate in the body.

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Dosing and administration

Tablets should be taken orally - adults at 2 doses per day in a dosage of 100 mg. In case of acute need, the dosage can be increased to a maximum of 400 mg per day. It is recommended to drink tablets or suspension before meals. But if there are uncomfortable sensations in the stomach, it is allowed to take the medicine after eating.

Dispersible tablets should be dissolved in water (one teaspoon is enough for 1 tablet) and drink after eating.

For children from 2 years of age, the drug is administered in the form of an oral suspension, and from 3 years - it can be administered both in the form of an oral suspension and dispersible tablets. Children from 12 years are allowed to take regular tablets. The required dose is calculated in relation to the weight of the patient - 3-5 mg / kg. For adolescents with a weight of more than 40 kg, Nyz can be given in adult dosage - twice a day in a volume of 100 mg.

The gel must be treated with the skin (it must be washed before the procedure and then dried). A little gel should be applied to the most painful area and rubbed until a uniform layer of the drug is formed. Perform the treatment should be 3-4 times a day.

The duration of treatment Naizom is 10 days.

Use Nyz during pregnancy

Contraindicated in the use of drugs during pregnancy or lactation.

Contraindications

Among the contraindications:

• exacerbated gastrointestinal ulcer;
• individual intolerance of the elements of the drug;
• hepatic or renal failure;
• aspirin bronchial asthma;
• diabetes mellitus (type 2);
• congestive heart failure;
• elevated blood pressure;
• Children's age is less than 2 years.

Children under the age of 12 can not take medicine in the form of tablets.

The gel can not be used in the following cases: if there are damages to the skin, infectious processes at the treatment site, and also with dermatoses.

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Side effects Nyz

Due to the use of Naise, such adverse reactions are possible: dizziness and headaches, a feeling of drowsiness, vomiting with nausea, diarrhea and pain in the stomach. In addition, heartburn, melena, toxic form of hepatitis, the appearance of ulcers on the mucosa of the gastrointestinal tract and petechiae. Oliguria, purpura, anemia, thrombocyto- and leukopenia, puffiness, hematuria, agranulocytosis and an increase in the activity of transaminases in the liver can also develop. Possible manifestations of allergies - rashes on the skin or anaphylaxis.

Due to the use of the gel, local negative reactions - peeling or itching on the skin, as well as urticaria - are possible. If in this case there is a physiological change in the skin tone, it is not necessary to abolish the use of drugs. In the case of gel treatment of large areas of the skin, the same systemic adverse reactions are possible, as well as after taking the tablets.

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Overdose

Overdose manifests itself under the guise of increased side effects - mainly such as hepatic insufficiency, a disorder in the work of the kidneys, the appearance of seizures, irritation of the gastrointestinal tract, an increase in the indices of AD and respiratory depression.

In case of such symptoms, you must immediately cancel the treatment with Naiz, and then conduct a therapy aimed at eliminating these symptoms by first performing the procedure for washing the stomach and giving the patient an activated charcoal. The medicine does not have a specific antidote, and the processes of forced diuresis or hemodialysis can not provide the necessary effect.

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Interactions with other drugs

The drug can increase the toxicity and drug effect of individual drugs, because it competes with them for binding to plasma proteins.

Naise can interact with such drugs as digoxin, phenytoin, methotrexate, cyclosporine, and in addition to hypotensive drugs, diuretics, lithium drugs, other NSAIDs, anticoagulants and orally administered antidiabetics.

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Storage conditions

The medicine in the form of tablets (both types) should be kept in a place protected from moisture and sunlight. The temperature regime for all types of drugs should be a maximum of 25 ° C. The gel should not be frozen.

Shelf life

Naize in tablets is allowed to be used for 3 years from the date of manufacture of the medicine. Gel - no more than 2 years.