The immune system can respond to norbactin in a variety of ways, from banal urticaria to the development of Quincke edema, Lyell and Steven-Johnson syndromes, etc. The drug causes a hypersensitivity reaction to insolation. This should be taken into account by all patients undergoing treatment and avoid sunlight whenever possible.
From the musculoskeletal system - inflammatory processes in tendons and joints, muscle and joint pain up to the destruction of myocytes and rupture of tendons.
From the side of the cardiovascular system, hypotension can be observed up to loss of consciousness, increased heart rate and heart rhythm disturbance until, in rare cases, flutter and fibrillation of the ventricles of the heart or spindle-shaped ventricular tachycardia (QT interval elongation syndrome on the cardiogram) develop, vasculitis.
On the part of the hematopoietic system - a decrease in the level of leukocytes, neutrophils, platelets, hemoglobin, the volume of red blood cells, an increase in the level of eosinophils.
On the part of the central and peripheral nervous system, dizziness, migraines, fainting, drowsiness, mood disorders, confusion, up to psychosis, convulsions, hallucinations, are more common; in addition - trembling in the limbs, muscle twitching and tics, polyneuropathy, myasthenia gravis, upset taste sensations.
The digestive organs can have abdominal pains of various localization, including moderate gastralgia, dyspeptic symptoms and loss of appetite, a feeling of bitterness in the mouth, inflammation of the small intestine and pancreas (usually with prolonged use).
The urinary organs can respond to the intake of norbactin by the formation of crystalline compounds, inflammation of the kidneys, delayed or excessive excretion of urine, hematuria, an increase in creatinine levels, and in rare cases, acute renal failure develops.
Skin manifestations can be limited to swelling, itching and rash, in rare cases, stronger and more severe reactions are possible - intra- and subcutaneous hematomas, exanthema, multiple, papules and boules merging into the cortex with vascular involvement and hemorrhagic manifestations.
On the part of the liver, the development of its inflammation, jaundice, changes in the activity of transaminases is possible.
From the side of the organs of vision: increased lacrimation, blurred vision and other disorders.
Hearing organs - noise and ringing in the ears, deafness.
Genitals - candidiasis colpitis.
Shortness of breath and respiratory dysfunction may develop.
Given the side effects of the cardiovascular and central nervous system during treatment with norbactin, you should refrain from work associated with the risk of a decrease in concentration.