Non-ticket

The non-ticket has antianginal, anti-arrhythmic and antihypertensive effects.

Indications Unfettered

It is used to lower elevated values of blood pressure, as well as in cardiac ischemia.

[1], [2], [3]

Release form

The drug is released in tablets, which are packaged in blister plates in the number of 7 or 14 pieces. Inside the box there are 1, 2 or 4 plates.

Pharmacodynamics

The medication helps to lower blood pressure values both in a calm state, and under stress or physical stress. Selective and competitive blocking of extra-synaptic as well as synaptic β1-adrenergic receptors is made, due to which they become inaccessible to catecholamines, and in addition, the process of vasodilating endothelial or NO release is transformed.

The antihypertensive effect of the Ticket is due to the weakening of the PAC activity, although there is no direct correlation with the change in renin activity within the blood plasma.

At the initial stage of therapy, it is possible to increase the values of OPSS, although then they gradually normalize and even decrease.

Antihypertensive effects are observed after 2-5 days of therapy, and persistent effects persist for 1-2 months. At the same time, the need for myocardium in obtaining oxygen decreases, the number of angina attacks decreases and their severity decreases, and the tolerance of physical exertion increases.

The antiarrhythmic effect is expressed by the impact on the pathological cardiac automatism and the significant inhibition of the AV conductivity.

[4], [5],

Pharmacokinetics

A non-ticket at high speed is absorbed inside the gastrointestinal tract, and eating does not affect the degree of absorption. The drug is completely synthesized with protein.

Exchange processes mainly occur inside the liver. At the same time, active metabolic products are formed.

Excretion of the drug is carried out through the intestine with the kidneys.

[6], [7], [8]

Dosing and administration

The drug is consumed orally, at the same time of day, without binding to food intake, washing down tablets with plain water.

The average dosage per day is 2-5 mg. This dosage should be consumed 1-fold per day.

When treating people with a deficiency of renal function, over 65 years of age, a day is prescribed to take 2.5 mg of the substance.

If necessary, it is allowed to increase the size of the portion to 10 mg.

[12],

Use Unfettered during pregnancy

Use the drug during lactation or pregnancy should be extremely cautious - only on strict indications and under the supervision of a specialist.

Contraindications

The main contraindications:

• the presence of intolerance against medicinal components;
• heart failure;
• AND;
• severe bradycardia;
• disorders of hepatic activity in a serious stage;
• decreased values of blood pressure;
• cardiogenic shock;
• SSSU;
• myasthenia gravis;
• pheochromocytoma or angina pectoris;
• state of depression;
• pathology of the obliterating character, affecting the peripheral vessels;
• weakness in the muscles.

[9], [10]

Side effects Unfettered

The use of medication can trigger such side effects as dizziness, paresthesia, fatigue, headaches, constipation, nausea, dry mouth mucosal and diarrhea.

There may also be edema, heart failure, bradycardia, heart rhythm disorders, orthostatic collapse, and in addition depression, insomnia, Raynaud's disease, hallucinations and drowsiness. In addition, hyperhidrosis, runny nose, photodermatosis, bronchial spasm and allergy symptoms can develop.

[11]

Overdose

When poisoning with a medicine, the appearance of such symptoms may appear: nausea, heart failure, lowering of pressure indicators, sinus type bradycardia, bronchial spasms, cyanosis, cardiogenic shock, and in addition vomiting, coma and heart failure.

To eliminate the disturbances, gastric lavage is performed, the activated charcoal is given to the affected person, and the required medications are administered. These measures can only be carried out by medical specialists.

[13]

Interactions with other drugs

Combination of the drug with anesthetic medications can cause the development of a cardiodepressant effect that increases the likelihood of lowering blood pressure.

The combination with antihypertensive medications, nitroglycerin and substances that block the slow Ca channels, leads to a sharp and strong decrease in blood pressure.

The use of reserpine, clonidine, antiarrhythmic drugs, guanfacin and α-methyldopa causes an increase in the severity of bradycardia. A combination with clonidine is capable of potentiating the "cancellation" syndrome.

Combination with microsomal oxidation inducers (such as barbiturates and rifampicin) can reduce plasma LA values. In this case, individual inhibitors (for example, cimetidine), on the contrary, increase these indices.

[14], [15], [16]

Storage conditions

The ticket must be kept in standard conditions for medicines, in a place that is closed from penetration of small children.

Shelf life

A non-ticket can be applied within 36 months from the date of manufacture of the therapeutic agent.

Application for children

Apply Nebilet in pediatrics can not be (persons under 18 years of age).

Analogues

The analogues of the drug are Medications Nebivator, Nebilong with Binelol, and in addition Nevotenz, Nebivolol and Nebikor with Bivotenz.

[17]

Reviews

A non-ticket is often discussed at forums devoted to methods of treating such disorders, such as elevated blood pressure or angina pectoris. It should be borne in mind that the causes of such diseases can be diverse, because of what the effect of the drug may be different for each individual patient.

The patients' opinions about the drug are rather ambiguous - some people talk about the positive effect of drugs, but someone does not help at all. But still the drug is suitable for most patients - they note a significant improvement in health status.

But we must remember that the medication does not affect all patients. In such cases, you just need to choose a suitable replacement, after which the desired effect will be achieved.