Nebilet

Nebilet has antianginal, antiarrhythmic and antihypertensive effects.

Indications Nebilette

It is used to reduce high blood pressure, as well as in cardiac ischemia.

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Release form

The drug is released in tablets, which are packed in blister strips in the amount of 7 or 14 pieces. Inside the box there are 1, 2 or 4 strips.

Pharmacodynamics

The drug helps to reduce blood pressure both at rest and under stress or physical exertion. Selective and competitive blocking of extrasynaptic and synaptic β1-adrenoreceptors is carried out, due to which they become inaccessible to catecholamines, and in addition, the process of release of endothelial vasodilator factor or NO is transformed.

The antihypertensive effect of Nebilet is due to the weakening of RAS activity, although there is no direct correlation with changes in renin activity in blood plasma.

At the initial stage of therapy, an increase in the values of OPSS is possible, although they then gradually normalize and even decrease.

The antihypertensive effect is observed after 2-5 days of therapy, and the persistent effect lasts for 1-2 months. At the same time, the myocardium's need for oxygen is reduced, the number of angina attacks decreases and their severity decreases, and physical exercise tolerance increases.

The antiarrhythmic effect is expressed by the impact on relatively pathological cardiac automatism and significant inhibition of AV conduction.

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Pharmacokinetics

Nebilet is absorbed at high speed inside the gastrointestinal tract, and the degree of absorption is not affected by food intake. The drug is completely synthesized with protein.

Metabolic processes mainly occur inside the liver. In this case, active metabolic products are formed.

Excretion of the drug occurs through the intestines and kidneys.

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Dosing and administration

The medicine is taken orally, at the same time of day, without regard to food intake, with the tablets washed down with plain water.

The average daily dosage is 2-5 mg. This dosage should be taken once a day.

For therapy in people with renal insufficiency, over 65 years of age, 2.5 mg of the substance is prescribed per day.

If necessary, the portion size can be increased to 10 mg.

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Use Nebilette during pregnancy

The drug should be used with extreme caution during lactation or pregnancy - only according to strict indications and under the supervision of a specialist.

Contraindications

Main contraindications:

• the presence of intolerance to medicinal components;
• heart failure;
• BA;
• severe form of bradycardia;
• severe liver dysfunction;
• decreased blood pressure values;
• cardiogenic shock;
• SSSU;
• myasthenia;
• pheochromocytoma or angina pectoris;
• state of depression;
• obliterative pathologies affecting peripheral vessels;
• weakness in the muscle area.

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Side effects Nebilette

The use of the drug may provoke such side effects as dizziness, paresthesia, fatigue, headaches, constipation, nausea, dry mouth and diarrhea.

Edema, heart failure, bradycardia, heart rhythm disorders, orthostatic collapse, as well as depression, insomnia, Raynaud's disease, hallucinations and drowsiness may also occur. Hyperhidrosis, rhinitis, photodermatosis, bronchial spasm and allergy symptoms may also develop.

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Overdose

In case of poisoning with the drug, the following symptoms may appear: nausea, heart failure, decreased blood pressure, sinus bradycardia, bronchial spasms, cyanosis, cardiogenic shock, and also vomiting, coma and cardiac arrest.

To eliminate the disorders, gastric lavage is performed, activated carbon is given to the victim, and the required medications are administered. Only medical specialists can carry out these measures.

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Interactions with other drugs

Combining the drug with anesthetic drugs may cause the development of a cardiodepressant effect, increasing the likelihood of a decrease in blood pressure values.

Combination with antihypertensive medications, nitroglycerin and substances that block slow Ca channels leads to a sharp and strong decrease in blood pressure.

The use of reserpine, clonidine, antiarrhythmic drugs, guanfacine and α-methyldopa causes an increase in the degree of bradycardia. Combined use with clonidine can potentiate the withdrawal syndrome.

Combination with inducers of microsomal oxidation (such as barbiturates and rifampicin) can reduce plasma values of the drug. At the same time, individual inhibitors (for example, cimetidine), on the contrary, increase these indicators.

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Storage conditions

Nebilet must be kept in standard conditions for medicinal preparations, in a place closed to the access of small children.

Shelf life

Nebilet can be used within 36 months from the date of manufacture of the therapeutic agent.

Application for children

Nebilet cannot be used in pediatrics (persons under 18 years of age).

Analogues

Analogues of the drug are the drugs Nebivator, Nebilong with Binelol, and also Nevotens, Nebivolol and Nebicor with Bivotens.

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Reviews

Nebilet is often discussed on forums dedicated to methods of treating disorders such as high blood pressure or angina. It is important to take into account that the causes of such diseases can be varied, which is why the effect of the drug may be different for each individual patient.

Patients' reviews of the drug are quite mixed - some talk about the positive effect of the drug, while others find it of no help at all. However, the drug is suitable for most patients - they note a significant improvement in their health.

But it is important to remember that the medication does not work for all patients. In such cases, you should simply choose a suitable replacement, after which the desired effect will be achieved.