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Non-hormonal ointments from psoriasis: a list of effective drugs
Last reviewed: 23.04.2024
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Psoriasis means genetic disease of the skin, which is accompanied by a rash, flaking, itching. This disease significantly limits the normal life activity of a person. In addition, that the disease is accompanied by a constant itch, which gives a person discomfort, there are other unpleasant symptoms. For example, the rash does not make the appearance of the patient attractive. Peeling, which at times resembles lichen, repels people. All this entails not only problems associated with the disease, but also psychological problems and discomfort.
The disease has been known for a long time, at various times in different countries was called differently. In the Middle Ages, this disease was considered a generic curse. In fact, everything is much simpler - there is a hereditary predisposition to this disease, which determines the person's inclination to the disease.
A distinctive feature of the disease is that it almost never completely cures. It is a chronic disease that has a sluggish character with occasional flashes of exacerbations. You can stop these exacerbations and alleviate the patient's condition in various ways. It must always be remembered that the disease is incurable. Cure it completely impossible, but you can eliminate the symptoms, ease the condition.
The exact causes of the disease are not fully understood. Currently, there are numerous discussions about the causes of the disease, its origin. In many ways, the opinions of scientists differ, but the only thing that all experts agree about - the disease is genetic, is passed down from generation to generation.
In addition to hereditary predisposition, however, there is variability. External factors affect the course of the disease. For example, stresses, climate change, neuropsychic overstrain, malnutrition can trigger an exacerbation of the disease. Medicines, hormonal, non-hormonal ointments from psoriasis, can ease the course of the disease.
Due to the fact that the cause of the disease is not yet fully understood, etiologic therapy of speech can not go. Treatment can only be complex. In addition to drug treatment, you also need to follow the regime of the day, diet, eat right, try to improve the quality of life. It is necessary to take measures that will help prolong the period of remission.
At the heart of all medical and preventive measures aimed at overcoming the symptoms of psoriasis, is medical therapy. Local and general drugs are used. In psoriasis, primarily non-hormonal ointments from psoriasis are used.
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Indications of the non-hormonal ointments from psoriasis
All drugs that will be described in this article are used to treat and relieve the main symptoms of psoriasis. Since this disease is chronic and lethargic, medicamentous and alternative remedies can be used only to get rid of the main symptoms and improve the overall health of the patient. But this does not mean that treatment is not necessary. The fact is that the so-called psoriasis plaques are a good place for the development of pathogenic microorganisms. Therefore, patients are advised to constantly monitor the health of their skin and prevent the recurrence of psoriasis.
The main importance of non-hormonal ointments is the ability to quickly and effectively eliminate the problem, achieve the desired effect in a short time. At first glance, it seems that ointments that do not contain hormones can not carry in themselves threats and dangers. But this is far from the case. These ointments are no less dangerous. They can cause many side effects. There are numerous contraindications. Therefore, in order to protect themselves, it is recommended to use drugs only after a preliminary consultation with a doctor.
In general, ointments can be used in the event that there are signs of exacerbation of psoriasis, if the condition has deteriorated significantly. As soon as the first signs appeared, they can be considered an indication for the use of ointment. There are many different ointments that differ in the mechanism of action, composition, the main active substance. You can find the best option only after consulting a doctor.
The indication is a pronounced rash, irritation, redness of the skin. All this is accompanied by severe itching. There may be other skin lesions. There are ointments that are designed to treat the scalp. There are ointments intended for the treatment of nails.
Apply ointments externally. In rare, exceptional cases (and not all species), can be recommended for internal use with various lesions of internal organs and mucous membranes. The peculiarity of non-hormonal ointments is that they can be prescribed for non-infectious dermatitis. They also proved to be good at rashes of various nature. In cases where the cause of the rashes is unclear, these ointments are also used.
Non-hormonal ointments are shown at the initial stage of the disease. They have a positive effect with eczema, neurodermatitis, seborrhea. They can also be useful not only for psoriasis, but also for various types of lichen. They help to get rid of pressure sores, non-healing wounds, erysipelas. Can be useful even in the early stages of gangrene.
They have a powerful effect in the composition of complex therapy for various dermatological diseases.
Release form
Usually non-hormonal drugs for the treatment of psoriasis are produced in the form of ointments.
Names of non-hormonal ointments from psoriasis
There are non-hormonal ointments that have proven themselves in the treatment of psoriasis and other dermatological diseases. Below are the names of the most effective nonhormonal ointments:
- Acustal
- Acriderm
- Antipsoriasis
- Kartalin
- Cryodermine
- Salicylic ointment
- Zinc ointment
- Zinocap
- Daivonex
- Losterin
- Psoriaten
- Videestim
- Magnesor
- Psoriazin.
Pharmacodynamics
The use of nonhormonal ointments makes it possible to avoid the progression of the disease, to prevent the development of the pathological process. Due to its basic properties, it eliminates many skin problems. The main action is gentle, gentle. Relieves inflammation, stops the manifestation of an allergic reaction. They form a reliable barrier that does not allow infection to enter the body, and contribute to the development of the disease even more intensively.
Have a significant advantage in comparison with hormonal ointments. First, non-hormonal ointments can be characterized as relatively safe, if we compare them with hormonal. Hormonal ointments lead to many serious consequences. Even if they have a quick and lasting effect, this does not mean that they are useful. They produce the opposite effect. The active substance by its nature is a hormone that penetrates into the body, is built into the metabolic chain and begins to regulate the functions of the body.
Because it is a synthetic hormone, it is foreign to the body. The whole system of regulation of the organism is violated. Serious consequences can occur, such as a metabolic disorder, a violation of the activity of endocrine glands, a violation of the reproductive system, the development of tumors, malignant tumors. Such effects are not observed in non-hormonal ointments. Therefore, in terms of impact on the hormonal system of the body, they are relatively safe.
But this does not mean that they do not have a negative effect on the body and their use can be abused. Thus, ointments of non-hormonal origin can contain in their composition no less dangerous substances, which also have a negative effect on the general condition and state of health of the patient.
Non-hormonal ointments contain a large number of different toxic, potent substances. On the one hand, it has a positive effect on the skin condition, relieves the symptoms of psoriasis, dermatitis of various nature. On the other hand, toxic substances penetrate the blood, carry blood throughout the body, ensure their effect on tissues and organs.
In this regard, non-hormonal ointments are mostly contraindicated for pregnant and lactating women, children up to a year. Many ointments can also have a negative effect, which manifests itself as intoxication, allergic reactions, aggravation of diseases. There is a progression of the disease with improper administration of such medications.
The best way to use non-hormonal ointments is to use them as part of a combination therapy. They can be well combined with medicines, ointments, creams. As part of complex therapy, some substances react with each other, and have a complex effect on the body.
In addition to local, local effects on the body, ointments also have a systemic effect.
Pharmacodynamics is based on the ability of active substances to penetrate the dermatological barrier. This makes it possible to spread throughout the body with blood, to penetrate into the tissue fluid, to correct endocrine and metabolic disorders. Penetrating into tissues, ointment promotes the enhanced synthesis of tissue mediators. The main effect of mediators is that they significantly reduce the inflammatory process. Mediators are easily spread with blood flow through the body, can stimulate the activity of the immune system.
Thus, non-hormonal ointments can be successfully used in inflammatory processes on hands, feet, elbows, palms, feet, hands. Significantly affect the elimination of dry skin, prevent peeling.
Ointments for action are different. They can affect the inflammatory processes of various etiologies. For the removal of various inflammatory processes, mainly Daivonex is used. By the mechanism of action, it is similar to vitamin D.
The mechanism of action of Acrostal is aimed at normalization of metabolic processes in the body. The ointment is aimed at removing irritation of the skin. The skin is substantially smoothed. In the cells of the epidermis, metabolic processes are normalized.
Non-hormonal ointments contribute to the rejuvenation of the epithelium, in which the skin of the upper layer slides. Also reduces the pain syndrome.
Salicylic ointment acts on the scalp, hair. Zinc ointment adsorbs toxins, exfoliates the particles of the epidermis.
One of the most effective drugs for the treatment of psoriasis is "Daivonex", so here we will review its pharmacodynamics and pharmacokinetics.
Calcipotriol is an analogue of vitamin D. It helps stimulate morphological differentiation and, at the same time, suppress the proliferation of keratinocytes. It is this action that underlies the fight against psoriasis. In addition, this substance is a potent inhibitor of T-lymphocyte activation, which is caused by interleukin 1. Calcipotriol is hundreds of times weaker than vitamin D3 for calcium metabolism.
Transdermal absorption of the main active substance of the drug is 1-5% of the total dose. Calcipotriol very quickly biotransformiruetsya in the liver, forming pharmacologically inactive metabolites. Has a short half-life.
Pharmacokinetics
At the heart of the action of non-hormonal ointments is the ability of the active substances to penetrate into tissues, into cells. The active substance passes through the dermatological barrier. The substance penetrates through the barrier into the deep layers, penetrates into the cells of the dermis, enters metabolic processes at the tissue and cellular level. Embedded in the metabolic chain, substances stimulate metabolic processes, and also contribute to the production of the necessary hormones, tissue mediators. These substances are released into the blood, then trigger a series of biochemical reactions, as a result of which the body is reconstructed, produces substances that reduce the inflammatory process. In addition, these substances can provide protection against irritants.
Dosing and administration
The way of application of all ointments is external. Ointment should be applied to areas that are affected by psoriasis, or other pathology. Apply a thin layer. The frequency of application and duration of treatment depends on the characteristics of the course of the disease, the severity of the disease, the individual characteristics of the organism. The method of administration, dosage is prescribed by the doctor.
Before applying the ointment, it is recommended to try on a separate area of the skin (on a small area). If an adverse reaction does not occur, you can apply ointment to the entire area of lesions. Children are advised to treat affected areas at specified intervals. Only one zone is processed at a time.
All non-hormonal ointments from psoriasis can be conditionally divided into the following types:
- Indifferent ointments.
- Means with vitamin D.
- Ointments with oil.
- Vitamin ointments.
- Homeopathic preparations.
- Funds based on solidol.
The main indifferent ointments for fighting the symptoms of psoriasis:
Salicylic ointment. This is a known keratolytic agent that is used to treat many skin diseases. Very often it is prescribed for exacerbation of psoriasis. The main component is salicylic acid.
For complex treatment of psoriasis use a two-percent salicylic ointment. It can be mixed with petroleum jelly to improve the effect. Apply to the problem skin before bedtime in a small amount. Top cover with a napkin and apply a bandage. It is recommended to change the dressing every day.
The drug can not be used for individual intolerance to salicylic acid, in early childhood, with kidney failure. The main side effects are: allergy, itching, redness, burning, fever.
Zinc ointment. Active active component of the drug is zinc oxide. It differs anti-inflammatory, astringent, drying, antiseptic and adsorbing action. Helps reduce inflammation, redness, creates a protective barrier on the problem skin.
It is applied topically, externally. The duration and dosage depends on the symptoms of psoriasis and the degree of the disease, therefore it is administered individually. Among the side effects is: an allergy, skin rash, itching, burning, flushing. Do not use if you are sensitive to the main component.
Means with vitamin D:
Psorkutan. Ointment for external use, which helps normalize proliferation, as well as differentiation of keratinocytes. The active ingredient is calcipotriol. It is considered an analog of vitamin D.
Contraindicated in pregnancy and lactation, on the progressing stage of psoriasis, with pustular psoriasis, severe liver and kidney disease, individual intolerance of the components. The main side effects of the drug are: allergies, local skin irritations, itching, burning, redness, dermatitis, dry skin, reversible increase in serum Ca2 + level.
Ointment should be applied only to problem areas once or twice a day. Note that the maximum daily dose is 15 ml of the drug. Therapy can not last more than 1 year. It is not recommended to use with salicylic ointment.
Daivonex. It is an effective non-hormonal drug based on calcipotriol. It is used for the treatment of vulgar psoriasis. The drug is contraindicated for individual intolerance of ointment components and diseases, which are accompanied by a violation of calcium metabolism. Do not give pregnant women, nursing mothers, children under 6 years. Among the side effects are: burning, itching, rash, dermatitis, pain, erythema, folliculitis.
Ointment is applied to the affected skin twice a day. As a rule, the effect is noticeable after 1-2 weeks of use.
Ointments with oil:
Naphthalan Ointment (psori-naft, dermo-naphtha). Active active component of the ointment is naphthalan oil. It is used for various diseases of the skin, including psoriasis in a stable phase. You can not use people with chronic heart failure, malignant tumors, acute inflammatory infections, blood diseases.
Please note, when interacting with UV irradiation, the results will be increased. During pregnancy, use only under the supervision of a doctor.
Before applying to the affected skin, the ointment is first heated to +38 degrees. After 20 minutes, the drug is rinsed. The duration of the course is twenty sessions, which are held daily.
Among the side effects should be allocated: allergy, itching, burning.
Vitamin Ointments:
We'll see. Non-hormonal ointment from psoriasis on the basis of vitamin A. It can not be used with: pregnancy (first trimester), hypervitaminosis A, chronic pancreatitis, cholelithiasis. Among the main side effects are: lethargy, drowsiness, headache, vomiting, nausea, flushing of the face, increased cerebrospinal pressure (at an early age), skin rashes.
Apply according to the doctor's prescription. Dosage is selected individually, depending on the severity of the disease.
Homeopathic preparations:
Psoriathen. Homeopathic drug, which is effectively used to treat psoriasis. The basis of the ointment is the matrix tincture Mahonia aquifolium D1. Do not use with individual intolerance of the drug components.
Apply to affected areas of the skin (adults and children from one year) three times a day. Lightly rub with massage movements.
With the use of ointment, allergy is very rare.
Funds based on solidol:
The cytoplasm. Non-hormonal ointment, which is actively used to treat the main symptoms of psoriasis. Apply to the affected areas of the skin with a very thin layer, rub. Within 2-5 weeks, redness and inflammation on the skin pass.
Active active components of the ointment are fatty salts and mineral substances. Dosage is selected individually.
Dosing and Administration
Most of these drugs cause a small layer only on the affected skin. Dosage, duration and frequency of use of the ointment is selected individually and depends on the degree of the disease and the strength of the manifestation of the symptoms.
Use of the non-hormonal ointments from psoriasis during pregnancy
Most ointments during pregnancy can not be taken. They contain potent, toxic substances that can adversely affect the development of the fetus. Many substances, penetrating into the blood, significantly change the metabolic processes in the body, which is also extremely undesirable in pregnancy. The ratio of hormones can be disturbed. Almost all active substances from ointments are able to penetrate the blood, and then through the placenta enter the blood of the child. They can cause a significant disruption to the development of the child, and may also disrupt the normal hormonal background of the mother and child.
In addition, ointments contribute to intensive recovery processes in the body. They contribute to the development, multiplication and division of cells. This is the basis of fetal development. The active substances of the ointment, penetrating into the body, interfere with the normal natural development of the fetal organism.
It is allowed to use ointment during pregnancy in the event that the positive effect of the effect of the ointment significantly exceeds the negative effect on the fetus. In any case, you can not use the ointment yourself. It is necessary to consult a doctor in advance.
It is necessary to know that not all ointments can be used during pregnancy. Some of them are categorically contraindicated. Negative effects on the fetus and the mother's body are noted when using zinocap, diveonex, psoriatica, magnesor and psoriazine during pregnancy. These ointments have numerous side effects, have many contraindications, have a dramatic effect on metabolism. They can also create additional stress on the heart, kidneys of the mother.
It is not recommended to use during pregnancy salicylic ointment, kartalin. The active substance in these ointments is salicylic acid, which strongly affects the human body. The most safe is zinc ointment, because it does not contain toxic, strong substances in its composition. The use can be contraindicated only if the person does not tolerate zinc oxide.
Losterin is also a safe ointment that can be used during pregnancy. It has anti-inflammatory, antibacterial effect. The occurrence of allergic reactions is also significantly reduced. No side effects are observed.
Videastim is not recommended only in the first trimester of pregnancy. But before you start taking it, it's best to consult a doctor. The main active ingredient is vitamin A, which is a powerful antioxidant. This substance promotes active redox reactions. Due to the action of these substances, the epithelium cells are intensified differentially. The skin is actively renewed. Also, the active substance inhibits the keratinization process.
You can use acustal. The substances that make up its composition are relatively safe and do no great harm to the fetus. The composition includes mainly plant extracts and oils. The preparation is supplemented with honey, beeswax, fatty solidol. This has a complex effect on the body. It works not only against psoriasis, but also against hypochromia.
Contraindications
Not all ointments can be used equally often. Many have their own contraindications. Almost all ointments will have a negative effect on the body if allergic or infectious processes occur in it. It is better to refrain from applying ointments during pregnancy and while breastfeeding. Children under 1 year of age can also be given ointments only as a last resort. Before applying the ointment on the entire affected area, check first how your body reacts to it. For this, a small test will help. Apply a thin layer on a small patch of skin. Wait for a while until the ointment starts to work. If you do not get sick, there are no visible reactions, no damage, you can safely apply the ointment to the entire site. Take the rule of consulting with a doctor before you start using any ointment.
If you have kidney problems, you better not use salicylic ointment. Then give preference to the zinc ointment, which is relatively safe. But this is only if you do not have an individual intolerance to zinc oxide. Check it easily with the above test. The same properties have a cynocap. But stopping your choice on this drug, you need to remember that it is incompatible with hormonal ointments and with any other hormone therapy.
If you are treated for liver or kidney failure, or you have elevated levels of calcium in the body - diveoneks just will not work.
It is best to take a closer look at losterin, psoriaten, acrustal - these are the safest drugs that have no contraindications, except for individual intolerance. Psoriatin should not be used only in the case of pregnancy and breastfeeding.
Videstim is not recommended if the skin is inflamed and is in an acute form of inflammation, and if there are problems with the kidneys.
Kartalin can not be applied to the skin of the face. And using it you need to remember that it is incompatible with the sun's rays, ultraviolet.
Psiatoren is not suitable in case a person has problems with kidney and liver, as well as in the presence of pyoderma and dermatitis. It is not combined with physiotherapy and sunbathing.
Side effects of the non-hormonal ointments from psoriasis
Side effects are very diverse. Practically there is no such ointment, which would not have side effects. The use of salicylic and zinc ointment can lead to increased itching, burning. Also, the process may be accompanied by severe hyperemia, edema. An allergic reaction may occur on the treated area. Zinc ointment can cause the skin to harden even more.
It is well tolerated by the body such ointments as cinnamon, losterin, psoriatic. The incidence of side effects is almost unknown. In rare cases, allergic reactions are possible, but this most often occurs if it is used too long or in excessive amounts.
But ointment davoneks has many side effects. This can be a reaction from the skin, the metabolism may be disturbed, the defensive function of the body may decrease. Itching and rash may be worse. Dryness of the skin rises, it can begin to peel more strongly. There may be phenomena of hyperpigmentation, or depigmentation. On the background of treatment, contact dermatitis, various eczema, can develop. Sometimes psoriasis is worse. There may be swelling on the face.
One of the most dangerous complications after taking this ointment may be a disruption of the normal functioning of the immune system, which usually manifests itself in the form of systemic angioedema, hives, allergies. There may even be constipation, appetite may decrease, fatigue may appear, problems with concentration of attention. In some cases, a decrease in muscle tone is observed. With the development of hypercalcemia, there is an increased fatigue, a constant sense of thirst.
Videstim can increase itching and flushing, allergic reactions may appear. The same applies to the reception of kartaline. These drugs should be taken with antihistamines. Also, drowsiness, headache, rashes on the skin may manifest itself.
Magnusor can cause itching and hives. The body temperature may rise. If acurstal is taken, local reactions, rashes, allergies may occur.
Psoradiidine can cause psoriasis, trigger its transition into a heavier form or into erythroderma. At the same time, the risk of allergic reactions and concomitant diseases increases sharply.
Overdose
Cases of overdose for non-hormonal ointments from psoriasis are practically unknown. In exceptional cases, there is an increase in psoriasis symptoms, itching, allergic reactions can occur.
Some drugs, for example, "Daivoniex " with an overdose can cause an increase in the concentration of calcium in the blood. If this happens, you must immediately stop treatment.
Effective non-hormonal ointment for psoriasis
Talk about the most effective ointment is inexpedient. In different situations, at different stages, different ointments may be required. In addition, do not forget about the individual characteristics of the body. One ointment can help one patient well, another can cause a number of side effects.
From the pharmacological point of view, if you analyze the ratio of contraindications and side effects, you can come to certain conclusions.
The most effective ointments can be recognized as zinc ointment and losterol. Doctors give preference to them because of the fact that their contraindications and side effects are minimized. They are prescribed even during pregnancy and during lactation.
Zinc ointment is well dried, known for its astringent effect. It promotes the adsorption and excretion of toxins from the body. This entails a reduction in inflammation, a reduction in itching. Ointment prevents the formation of exudate. It reliably protects from the adverse effects of external factors. Can be applied directly to the site of rashes. It is characterized by an optimal ratio of "price-quality" indicators.
The composition of losterin includes several basic drugs that have a therapeutic effect. Thanks to naphthalene, the anti-inflammatory effect fully realizes itself. This substance also dilates the blood vessels. Nutrition of the skin due to this is enhanced, metabolic processes come back to normal. Microcirculation improves.
Urea softens the skin, heals wounds, prevents the development of the infectious process. Promotes better absorption of the remaining components of the ointment.
Salicylic acid and D-panthenol heal wounds, prevent penetration and infection. Can exhibit keratolytic action. Improved recovery processes.
Plant extracts and oils nourish the skin, saturate with vitamins, soften and smooth the skin.
Contraindicated ointment with individual intolerance, special contraindications and side effects are not noted.
Attention!
To simplify the perception of information, this instruction for use of the drug "Non-hormonal ointments from psoriasis: a list of effective drugs" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.