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Non-hormonal drugs for menopause in women: list and reviews
Last reviewed: 03.07.2025
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Around the age of 45 (earlier for some, later for others), the reproductive function begins to fade in the female body: ovulation becomes less frequent, follicles stop forming, and the menstrual cycle gradually ceases. The approaching menopause often occurs with all sorts of unpleasant sensations for a woman - these are the "famous" hot flashes, headaches, sweating, etc. And, if for some women such symptoms can pass almost unnoticed, then others have to resort to the help of drugs to at least slightly alleviate their condition. The safest drugs for this physiological period, according to the general opinion of experts, are non-hormonal drugs for menopause - these are mainly herbal remedies or vitamin-based medications that do not disrupt the body's own hormone production and practically do not cause negative side effects.
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Indications non-hormonal medications for menopause
Non-hormonal drugs for menopause can be taken as soon as the first signs appear:
- for neurovegetative disorders (hot flashes, blood pressure surges, dizziness, tingling sensations, excessive dryness of the skin and mucous membranes);
- for psycho-emotional disorders (irritability, sleep and appetite disturbances, constant fatigue, impaired concentration, decreased work capacity);
- in case of metabolic disorders (osteoporosis, diabetes, excess weight, chondrosis, arthrosis, atrophic changes in the genitals);
- for cyclic disorders (dysmenorrhea).
Release form
Currently, the pharmaceutical industry offers a very wide range of non-hormonal drugs for menopause. Which drug is suitable in a given situation is decided by the doctor. Each woman is unique and special, so it is impossible to say with certainty which form of the drug will be the most optimal for her.
Some women prefer to take medications in tablet form - this is convenient, especially if they need to be taken outside the home.
Some people prefer remedies for menopause symptoms in drops – this form of the drug allows for very precise dosing of the medicine.
In addition to the listed forms, non-hormonal drugs are available in the form of injection solutions, granules or capsules.
Of course, everyone has the right to choose which drug to take. But before making your choice, it is still preferable to consult a doctor.
Names of non-hormonal drugs for menopause
Non-hormonal drugs for menopause may differ in their mechanism of action and in the medicinal affiliation of the active components. Based on this, homeopathic remedies, biologically active drugs, multivitamin complexes and herbal preparations (phytoestrogens) are distinguished.
- Non-hormonal drugs for menopause against hot flashes
The most popular non-hormonal drugs for menopause are homeopathic complex remedies. As a rule, they have virtually no side effects and have a very short list of contraindications: however, such medications are also prescribed by a doctor.
Homeopathic remedies act cumulatively, so the course of treatment with such drugs usually lasts several months. The effect of such drugs is stable and long-lasting.
- Remens is a homeopathic remedy made from cuttlefish glandular extract and snake toxin. The drug eliminates hot flashes, increased sweating, stabilizes mood, and activates metabolic processes. Remens is used both at the first signs of menopause and at the height of symptoms: the medication is contraindicated only in the presence of allergies.
- Klimaxan – has an estrogen-like effect, suppresses hot flashes, improves sleep, relieves headaches and dizziness. The drug is available in the form of tablets or granules.
- Klimadinon is a homeopathic drops based on the rhizome of black cohosh, vitamins and minerals. Klimadinon successfully combats hot flashes, urinary disorders, vascular and muscle spasms, and pressure drops.
No less widespread are homeopathic preparations from the German company Heel. Among them are such popular remedies as Klimakt-heel, Ovarium-compositum, Ovariamin.
- Non-hormonal dietary supplements for menopause
Non-hormonal biologically active supplements work due to the presence of plant estrogen-like substances in them – phytoestrogens. Such preparations are natural analogues of hormonal agents:
- Feminal is a supplement that is an extract from the red clover plant;
- Femicaps is a complex biological supplement with extracts of sacred vitex, passionflower, as well as primrose and evening primrose oils, and a number of essential vitamins;
- Inoklim is a soy preparation with the addition of gelatin and vegetable oil;
- Bonisan is a soy extract based supplement;
- Femivell is a dietary supplement, an analogue of Bonisan. Contains soy extract;
- Estrovel is a supplement that contains black cohosh, soy, wild yam and nettle extracts, as well as some vitamins and amino acids.
- Non-hormonal vitamins during menopause
Among the many non-hormonal drugs, multivitamin complexes with a specially combined composition can also restore physical and psychological health during menopause. The effect of such drugs is explained by the stimulation of the immune defense and the body's own forces. The most popular are the following:
- Menopace is a multivitamin with an additional increased content of minerals necessary during periods of active hormonal changes;
- Ladies Formula Menopause is a specially developed vitamin preparation containing tocopherol and B vitamins, as well as minerals and pantothenic acid. The product has a positive effect on the condition of the musculoskeletal system, prevents atherosclerotic changes in blood vessels, improves the functioning of the nervous system;
- Klimalanin is a drug whose action is based on the properties of the amino acid β-alanine;
- Biotredin is a drug based on L-threonine and pyridoxine. Improves metabolic processes and energy supply of tissues.
- Non-hormonal suppositories for menopause
With the onset of menopause, many women complain of vaginal dryness. This dryness manifests itself differently in everyone: from slight discomfort to loss of sexual interest and the development of inflammatory infectious diseases of the genitals.
The use of non-hormonal suppositories allows you to soften and moisturize the mucous membrane, restore or maintain beneficial microflora inside the vagina and prevent the development of infectious complications.
- Vagikal is a non-hormonal suppository based on calendula, which is known for its antimicrobial, immunostimulating and prophylactic properties.
- CiCatridina is a natural suppository with hyaluronic acid, calendula, aloe extract, etc. The suppositories relieve vaginal dryness and improve tissue turgor.
- Klimaktol - suppositories based on sea buckthorn, lemon balm, hops and valerian oils. Thanks to these suppositories, it is possible to restore the mucous tissues of the vagina, soothe itching and burning.
Pharmacodynamics
Non-hormonal drugs for menopause in the vast majority of cases "work" due to the estrogen-like effect on the body. After taking such medications, the production of some hormones decreases, which leads to a decrease in the level of LH. As a result, the woman's condition stabilizes, since the manifestations of a lack of sex hormones weaken. This mainly refers to a decrease in the severity of symptoms from the autonomic nervous system, which include hot flashes, hyperhidrosis, etc.
Non-hormonal drugs used during menopause often have a slight calming effect - this has a positive effect on sleep, relieves irritability and mood swings.
Pharmacokinetics
Most non-hormonal drugs that are intended to eliminate the negative symptoms of menopause have not been studied in terms of kinetic properties. Most often, the kinetic characteristics of such drugs are difficult to trace, since they contain a whole list of plant components with complex pharmacology.
It is known that non-hormonal drugs must be taken in courses - sometimes for several months. Only such treatment can guarantee relief from the negative symptoms of menopause and lead to lasting relief.
Moreover, most non-hormonal medications demonstrate a pronounced therapeutic effect already in the second week of their use.
Dosing and administration
Before taking any non-hormonal drugs, you should consult a gynecologist-endocrinologist. In addition, it is advisable to undergo a full examination of the reproductive organs to exclude diseases that could be a contraindication to treatment. It is very risky to choose and take any drugs on your own, since each drug has its own nuances of use, which only a doctor knows about.
To increase the effectiveness of non-hormonal treatment of menopause symptoms, doctors recommend making some changes to your diet. For example, it is very useful to include seafood (fish, seaweed, shrimp), liver dishes, potatoes boiled in their skins, sprouted wheat and bran in your daily menu.
Non-hormonal drugs for menopause are taken for at least 3 months in a row, otherwise the desired effect will not be achieved.
The doctor decides which drug to choose and in what quantity to take.
Contraindications
It is forbidden to use any means during menopause - even non-hormonal ones - in the presence of estrogen-dependent tumors (for example, cysts or breast cancer). In addition, there are a number of contraindications for certain non-hormonal drugs during menopause:
- Medicines based on black cohosh should not be used by people with lactose intolerance;
- Alcohol-based medications should not be used by those who suffer from alcohol addiction;
- You should not take herbal estrogen preparations if you have any pathologies of the brain or liver, or if you are prone to seizures;
- It is definitely not possible to take non-hormonal medications during pregnancy and breastfeeding;
- You should not take any medications if you are allergic to any of the ingredients in the drug.
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Side effects non-hormonal medications for menopause
Any medications to one degree or another cause side effects. Non-hormonal drugs during menopause are no exception. Rarely, but they can still cause the following symptoms:
- nausea;
- vomiting;
- yellowness of the sclera;
- a state of general weakness;
- stomach ache;
- loss of appetite;
- weight change;
- change in urine color.
Overdose
Non-hormonal drugs used during menopause are difficult to overdose on. However, if this does happen, the symptoms of overdose are manifested by increased side effects. If you take medications according to the treatment regimen suggested by your doctor, then it is impossible to take an excessive dose of medications: this can only be done accidentally or intentionally.
If an overdose does occur, it is necessary to wash out the stomach and intestines, then take activated charcoal (or another similar remedy), washing it down with a sufficient amount of clean water.
If any symptoms such as diarrhea or headache appear, then symptomatic treatment is additionally prescribed.
Interactions with other drugs
It is not recommended to take non-hormonal drugs for menopause at the same time as barbiturates and Rifampicin (an anti-tuberculosis drug).
Hormonal and non-hormonal drugs should not be combined without a doctor's permission - this especially applies to medications based on estriol and corticosteroid hormones.
Combinations of different herbal preparations, unless their kinetic properties have been studied, are also not recommended, as this may lead to an unpredictable effect.
Storage conditions
Most non-hormonal medications used during menopause can be stored in normal room conditions. Medicines should not be frozen or exposed to excessive heat: this is why medications should be kept away from heating devices and sunlight.
Non-hormonal suppositories are sometimes recommended to be stored in cool conditions – up to 8-12°C.
It is necessary to ensure that children cannot reach places where medicines are stored.
Effective non-hormonal drugs for menopause
For each specific organism, the effectiveness of drugs may manifest itself in different ways. After all, climacteric symptoms in many women differ significantly. You can make an approximate list of the most common non-hormonal drugs that are very successful at the first symptoms of menopause. Among such medications are:
- Klimadinon is a drop based on black cohosh, which has a visible effect already during the first 1-2 weeks of use;
- Remens is a combined homeopathic remedy intended for long-term treatment of not only pathological menopause, but also menstrual cycle disorders;
- Feminal is a biologically active substance that has an estrogen-like effect;
- Inoklim is a safe herbal preparation that eliminates the main symptoms of climacteric changes;
- Klimaxan - this herbal preparation is especially recommended for those women who have increased irritability, headaches, insomnia, and other psycho-vegetative disorders.
New non-hormonal drugs for menopause
The latest developments in medicines to eliminate the unpleasant symptoms of menopause help improve the condition of women, eliminating periodic hot flashes and menstrual cycle disorders.
Since hormonal changes directly affect the condition of the musculoskeletal system, new non-hormonal drugs often contain calcium and vitamin D 3 to prevent osteoporosis.
Most modern medications also have a positive effect on the external manifestations of menopause, improving the condition of the skin, nails and hair.
The most common new generation drugs are:
- Estrovel is a natural complex preparation that replenishes the lack of estrogen and stabilizes the hormonal background in the body;
- Tribestan is a tablet based on a dry extract of Tribulus. Tribestan has a strengthening, protective property, and also "rejuvenates" the female reproductive system;
- Ovarium compositum is a homeopathic preparation that supports the activity of the ovaries during pre-menopause and menopause, as it has an estrogen-like effect.
Non-hormonal drugs during menopause are the safest and most acceptable means. But before making a choice in favor of one or another means, it is necessary to consult a doctor.
Attention!
To simplify the perception of information, this instruction for use of the drug "Non-hormonal drugs for menopause in women: list and reviews" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.