Medical expert of the article
New publications
Preparations
Neyromin
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Neuromin is an antianemic substance containing cyanocobalamin.
Indications Neuromina
It is used for various anemias: post-hemorrhagic, malignant, iron-deficient nature, aplastic species (in children), alimentary, and in addition provoked by toxic components and medicines; also with other anemias resulting from lack of cyanocobalamin, regardless of what caused this deficiency (gastric resection, worms, pregnancy or intestinal absorption disorder).
It is used in radiculitis, polyneuritis, trigeminal neuralgia, migraines and causalgias, and in addition in Down syndrome, cerebral palsy, neuritis of a diabetic nature, delirium, which has an alcoholic nature, and Charcot's disease.
It is prescribed for sprue (combined with B9-vitamin), psoriasis, neurodermatitis, hepatic pathologies (cirrhosis or hepatitis), photodermatosis, and also for herpetiformis variety of dermatitis and radiation sickness.
Release form
The release of the component is realized in the injection fluid, inside the ampoules with a volume of 1 ml. The box contains 5 such ampoules.
Pharmacodynamics
Methylcobalamin helps activate protein, lipid and carbohydrate metabolism, is a party to the binding of labile categories, as well as the formation of methionine with creatine and choline with nucleic acids. At the same time, the cumulation of ligaments with sulfhydryl categories inside the erythrocytes helps. Being a growth factor, it activates the bone marrow activity necessary for the normal plastic form of erythropoiesis.
Methylcobalamin helps to stabilize the impaired functioning of NS and the liver, activates the processes of blood coagulation and (in large portions) leads to an increase in thromboplastic and prothrombin activity.
Inside the human and animal organism it binds inside the intestinal microflora, although it does not provide for the need to obtain the vitamin completely. Therefore, an additional part of this element is obtained with food.
[7]
Pharmacokinetics
The level of protein synthesis is 90%. The time to reach Cmax values in w / o and s / to use is 60 minutes.
Excretion is made with bile and through the kidneys. The substance may cross the placenta.
[8]
Dosing and administration
The medication should be used in / in, p / to or in / m by the method, and in addition to this intra-lumbar.
In the case of anemia associated with cyanocobalamin deficiency, adults should use 0.1-0.2 mg of the substance every other day, until remission is achieved.
In the case of the development of signs of funicular myelosis, as well as macrocytic anemia, accompanied by damage to the NA, the drug is prescribed to an adult in a 1-fold dose of 0.4-0.5 mg and above. During the 1st week it is used daily, and then with 5-7 days intervals (B9-vitamin is used along with the medicine). In severe stages of the disease, it must be injected into the region of the spinal canal, first in a single dose of 15-30 micrograms; with each new introduction, the dose should be increased (50, 100, and then 150 and 200 μg). Intra-lumbar injections should be carried out with 3-day breaks, and the whole cycle includes 8-10 injections. In remission, if there are no signs of the disease, 0.1 mg 2 times a month is administered as maintenance treatment; if neurological manifestations are present, 0.2-0.4 mg is administered 2-4 times per month.
In case of anemia of iron deficiency or post-hemorrhagic nature, 30-100 μg of the drug are used 2-3 times a week. In the case of an aplastic variant of the disease in a child, 0.1 mg of medication is used each time until clinical and hematological improvement is registered. In the case of an alimentary form of pathology (in infants) and anemia in a premature baby, 30 μg of the drug is required per day for 15 days.
During ALS or pathologies of a neurological nature, accompanied by pain, increasing portions are used within 200-500 mcg (after the appearance of improvements, 0.1 mg per day). The duration of the therapeutic cycle is not more than 14 days. In case of damage to the peripheral nerves, 0.2-0.4 mg of the substance should be applied 1-fold in 2 days over a 40-45-day period.
Infants with dystrophy after diseases, as well as with cerebral palsy or Down syndrome require 15-30 μg of the drug every other day.
In the case of hepatic cirrhosis or hepatitis, children's and adult dosages are 30-60 mcg per day or 0.1 mg every other day for a 25-40-day term.
During sprue, a diabetic variety of neuropathy or radiation sickness, 0.06-0.1 mg of medication is used daily (for 20-30 days).
The duration of the therapeutic cycle and the time for completing the repeated courses are determined by the nature of the pathology and the severity of the therapeutic effect.
[15]
Use Neuromina during pregnancy
It is forbidden to use Neuromine when breastfeeding or pregnancy, because there is no reliable clinical information.
Storage conditions
Neuromine is required to keep in the places closed from small children. Temperature - within the mark of 30 ° С.
Shelf life
Neuromine can be used within a 2-year period from the time the pharmaceutical product is released.
Attention!
To simplify the perception of information, this instruction for use of the drug "Neyromin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.