Neurodiclovitis

Neurodiclovit has antipyretic, anti-inflammatory and analgesic activity.

Indications Neurodiclovitis

It is used for such types of rheumatic pathologies:

• various neuralgia or neuritis;
• arthritis of pronounced gouty genesis, having an acute character;
• chronic type of polyarthritis or arthrosis;
• spondyloarthritis libido ankylosing spondyloarthritis;
• extra-articular rheumatism that affects soft tissue.

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Release form

The release of the component is in capsules - 10 pieces inside the cell package. The pack contains 3 or 5 such packages.

Pharmacodynamics

The drug has a non-selective suppressive effect on COX-1 with COX-2, and besides it reduces the level of PG in the area of inflammation and prevents the development of arachidonic acid metabolism.

In the case of rheumatic lesions, this drug reduces joint pain and swelling, as well as the intensity of stiffness in the morning. Due to this, the motor activity of the joints is significantly improved.

Pyridoxine hydrochloride stabilizes the function of HC. It is a coenzyme of important enzymes located inside the nerve tissue. At the same time, the substance is involved in the development of the biosynthesis of most neurotransmitters.

Thiamine hydrochloride, after passage into the body, is transformed into the cocarboxylase component. This substance is a coenzyme of most enzymes and an important part of metabolic processes. He takes an active part in the processes of neural synaptic excitation.

Cyanocobalamin helps normalize blood formation, as well as the maturation of red blood cells; is a member of a large number of biochemical processes required for the stable operation of the body. At the same time, the component has a positive impact on the processes occurring inside the NA. Coenzyme forms of this element are required for cell growth and renewal.

Pharmacokinetics

The combination of B-vitamins contained in the composition of the drug (cyanocobalamin with pyridoxine and thiamine) enhances the analgesic activity of diclofenac.

Diclofenac has full absorption at high speed, but the use of food slows down this process for a while (1-4 hours), and at the same time reduces the Cmax performance of the active element by 40%. With oral administration of capsules, the level of Cmax is noted after 2-3 hours. This indicator is linearly dependent on the size of the dosage used.

Bioavailability values of drugs are 50%; The substance has significant synthesis with blood protein. The half-life of synovia is approximately 4-5 hours. Cmax values inside synovia are recorded approximately 3 hours later than inside plasma.

Part of the active element (50%) is subjected to intrahepatic cleavage. The exchange processes develop after conjugation, as well as hydroxylation of the element with glucuronic acid. The participant in the splitting of drugs is the enzyme structure of P450 CYP2C9. In the form of metabolic elements through the kidneys excreted 65% of the drug, and even less than 1% of the substance - in unchanged condition. The residue is excreted along with the bile (also in the form of metabolic components).

The total clearance values are 350 ml / min. Plasma half-life is 2 hours. Diclofenac is able to stand out with mother's milk.

B-vitamins contained in the composition of neurodiclovit have water solubility. Thiamine is absorbed with pyridoxine inside the upper region of the small intestine. Basically this process depends on the size of the portion. Inside the body, substances undergo intrahepatic cleavage and are mostly excreted through the kidneys. Only about 9% of the drug is excreted in an unchanged state. If the medicine is taken in large portions, intestinal excretion of thiamine with pyridoxine increases.

The absorption of cyanocobalamin is largely determined by the presence of endogenous factors in the upper small intestine and stomach. The movement of this element is determined by the activity of transcobalamin. After intrahepatic cleavage, the component is excreted mainly from the bile. The liver excretes only about 6-30% of this vitamin.

Dosing and administration

The drug is required to be taken orally - capsules are swallowed whole during the meal, drinking medicine with plain water. The size of the dosage portions can vary depending on the degree of intensity of the pathology. The average portion is 1-3 capsules per day, which is equal to 0.1 g of diclofenac.

Adults usually begin to use the drug with the use of 2-3 capsules per day. The size of the largest daily portion should not be more than 3 capsules. The size of the maintenance portion is equal to the 1st capsule with 1-2 times daily intake.

Elderly people use medication with extreme caution.

Adolescents older than 14 years of age may use Neurodiclovit, but its highest dosage dose should be a maximum of 1 capsule 2 times per day.

The duration of the treatment cycle is determined by the medical professional.

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Use Neurodiclovitis during pregnancy

It is forbidden to prescribe neurodiclovit pregnant.

Contraindications

The main contraindications:

• severe intolerance associated with the components of the drug;
• bleeding affecting the digestive tract;
• BA, accompanied by polyposis of the nasal mucosa;
• hemostatic disorders;
• lactation period;
• disorders of hematopoietic processes;
• bleeding appearing inside the skull;
• lesions within the gastrointestinal tract with erosive-ulcerative etiology (especially during periods of exacerbation).

Caution is required when used in such conditions:

• CH, having a stagnant character;
• IHD or anemia, as well as BA;
• lack of liver or kidney activity;
• diabetes;
• having inflammatory genesis intestinal pathology;
• alcoholism;
• induced variety of porphyria;
• edema syndrome;
• diverticulitis;
• elevated blood pressure;
• systemic dysfunction of connective tissues;
• elderly people.

In addition, you need to carefully monitor the condition of the patient in cases where the drug is used after extensive operations.

Side effects Neurodiclovitis

Among the adverse signs of drug capsules:

• liver damage or gastrointestinal tract: elevated liver enzymes, diarrhea, abdominal pain, flatulence, constipation, nausea, bleeding inside the gastrointestinal tract and a peptic ulcer (complications can occur);
• dysfunction of the sense organs: ear noise;
• disorders of the urogenital system: nephrotic syndrome or oliguria with azotemia, development of fluid retention, proteinuria, and in addition tubulointerstitial nephritis, hematuria, acute renal failure and necrotizing papillitis;
• problems with the activity of the National Assembly: headaches or severe dizziness;
• lesions of the epidermis: itching or rash;
• disturbances in the functioning of the blood-forming organs and the immune function: leuko- or thrombocytopenia, eosinophilia, agranulocytosis, and besides this anemia, purpura of thrombocytopenic nature and worsening of the course of the existing infection.

Along with this, the following disorders occur occasionally in the liver or gastrointestinal tract: hepatic necrosis, pancreatitis, jaundice with colitis, hepatitis and aphthous form of stomatitis with cirrhosis, cholecystopancreatitis, and hepatorenal syndrome. In addition, there is melen, dry mucous membranes, vomiting and lesions in the esophagus.

Occasionally, there are dysfunctions of the central nervous system: a state of depression, a feeling of general weakness, sleep disturbance, a feeling of irritability, severe anxiety or drowsiness, and also nightmares, disorientation and convulsions. The epidermis can also be affected - eczema, urticaria, IEE, severe photosensitization, alopecia, PETN, toxic form of dermatitis and having a punctate hemorrhage.

Symptoms such as visual impairment, puffiness in the larynx, increased blood pressure, scotoma, taste disorder, impaired hearing, bronchial spasm, diplopia, pneumonitis, and cough are singularly appearing. In addition, a congestive form of heart failure, extrasystoles, pain in the sternum, myocardial infarction, anaphylaxis, edema, affecting the tongue and lips, some anaphylactoid signs and vasculitis, which has an allergic nature, are developing.

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Overdose

After using too large portions of the medication, such manifestations may occur: headaches, dyspnea, vomiting, and also dizziness and clouding of consciousness. In children, myoclonic seizures, nausea, abdominal pain, bleeding, and kidney or liver function disorders may occur.

To eliminate violations, gastric lavage and forced diuresis procedure are conducted, and in addition activated charcoal is prescribed. Symptomatic measures are also performed. Hemodialysis has almost no effect.

Interactions with other drugs

When using neurodiclovitis, an increase may be noted:

• lithium indicators when combined with lithium products;
• the intensity of the negative symptoms in the case of combination with other NSAIDs;
• the risk of bleeding inside the gastrointestinal tract when administered with GCS;
• therapeutic activity of potassium-sparing diuretics, as well as drugs that slow down platelet aggregation;
• toxicity and methotrexate levels.

The effect of the drug is weakened in the case of combination with antihypertensives and diuretic loop character. Indicators of the active component (diclofenac) are reduced when combined with aspirin. Absorption of cyanocobalamin is reduced in the case of the introduction of drugs with neomycin, colchicine, and in addition with hypoglycemic drugs (for example, biguanidine) and PAS.

It is forbidden to combine the drug with levodopa, because it can weaken the intensity of its anti-Parkinsonian influence. At the same time, it is capable of lowering the hypotensive properties of diuretic drugs and antihypertensive drugs, due to which this combination is used cautiously. During therapy is required to monitor blood pressure indicators. In addition, you need to drink a lot of fluid, and at the initial stage of the treatment cycle and after it ends, it is necessary to monitor the renal function, because nephrotoxicity can develop.

With combined use with the SSRI increases the likelihood of bleeding in the gastrointestinal tract.

Portion sizes of hypoglycemic substances should be carefully monitored when combined with neurodiclovitis.

The introduction together with colestyramine or colestipol reduces by about 30-60% the intensity of the absorption of diclofenac. Therefore, between the use of drugs is required to observe a few hours gap. Also indicators of diclofenac can reduce certain drugs that stimulate the activity of enzymes (phenytoin with hunters, as well as rifampicin with carbamazepine).

It is necessary to take into account that under the action of 5-fluorouracil, the effect of thiamine is inactivated, and antacids reduce its absorption. Loop diuretic drugs can slow down the reabsorption of thiamine tubules, and with prolonged therapy, lower its performance.

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Storage conditions

Neurodiclovit is required to be stored in a dark, dry and closed place from small children. The optimum temperature values are not higher than 25 ° C.

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Shelf life

Neurodiclovit can be used within a 36-month period from the time the therapeutic substance is produced.

Application for children

Do not use this drug in pediatrics.

Analogs

Analogues of drugs are Blokum B12, Fanigan, Doleks with Bol-Ran, Tsinepar, Diclokine, Maxigezik with Diclofenac, as well as Olfen-75 and Diclofenac C Paracetamol with Flamidez.