Nemocid

Nemotsid is antihelminthic medicine, which contains an element of pyrantel. The drug demonstrates its activity in the early phase of the development of helminths, and in addition affects their mature forms; at the same time, it does not affect migratory larvae.

The drug effect develops in diseases that are caused by the activity of pinworms, hookworm, human ascaris, Trichostrongylos orientalis, and hookworm duodenal and Trichostrongylos colubriformis.

Indications Nemocid

It is used in case of development of enterobiosis, ascariasis or ankilostomidosis.

Release form

The release of drugs produced in tablets - 3 pieces inside the cell plate; Inside the pack there is 1 such plate, and in the box - 10 packs.

In addition, it is sold in the form of a suspension for oral administration - in bottles with a capacity of 10 or 15 ml; In the box - 1 such bottle.

[1]

Pharmacodynamics

The drug acts by depolarizing the cell walls, which causes neuro-muscular paralysis in parasites. The result is a spasm of the musculature of helminths, which are then excreted during peristalsis of the gastrointestinal tract.

Pharmacokinetics

Pyrantel is poorly absorbed inside the intestine, primarily due to the low solubility of pyrantel pamoate. After ingesting a dosage of 10 mg / kg orally, the serum Cmax value is approximately 0.005-0.13 μg / ml and is noted after 1-3 hours.

Part of the drug is involved in intrahepatic metabolic processes, after which it is excreted in an unchanged state and in the form of derivatives. A maximum of 7% of the substance is excreted with urine.

[2], [3], [4]

Dosing and administration

The drug is used exclusively inside, after shaking the bottle with suspension (tablets must be chewed carefully before swallowing). The use of drugs does not require the use of laxatives, refusal of food or other preparatory procedures. A portion of the substance is allowed to take at any time of the day, regardless of the use of food. The doctor selects the dosage, taking into account the severity of the pathology and the personal characteristics of the patient.

In the case of ascariasis or enterobiosis, it is often prescribed to use 10-12 mg / kg of the drug. Children are usually given an average single dose of 125 mg / 10 kg, and for an adult (weight below 75 kg) - 1-fold intake of 0.75 g. If the weight of an adult is more than 75 kg, 1 g should be taken 1-fold. Medication.

During therapy with enterobiasis, one should adhere to all personal hygiene rules (it is especially important to keep track of this in young children). In addition, in the case of enterobiasis, after 3 weeks from the end of the course of therapy, a second one may be prescribed.

Persons with hookworm (severe stages of development or stay in endemic areas) are often used at 20 mg / kg for 1 to 2 uses in a period of 2 or 3 days. Children are prescribed an average portion of 0.25 g / 10 kg (1 single dose), for adults with a weight less than 75 kg - 1 times the use of 1.5 g of drugs, and for people with a weight over 75 kg - 2 g (1 -time)

In the case of light invasions in non-endemic areas, 10 mg / kg of the drug can be administered 1 fold.

[5]

Use Nemocid during pregnancy

When testing pyramid pyramid with animals, there was no teratogenic effect on the fetus and a negative impact on the course of pregnancy. Data on the negative impact on pregnancy and fetal development are not available, but Necicide can only be used from the prescription of a medic, after evaluating all possible risks.

When breastfeeding medication is used only in the presence of strict indications and after determining the balance of benefits and risks.

There is no information regarding the effects of drugs on fertility.

Contraindications

The main contraindications:

• strong sensitivity in relation to pyrantel or additional elements of the drug;
• use in people with impaired hepatic function.

Side effects Nemocid

The use of drugs only occasionally leads to the appearance of adverse symptoms. Due to the weak systemic absorption of the drug, the likelihood of developing common manifestations is rather low, but there are isolated reports of the appearance of such signs:

• CNS damage: drowsiness, confusion, dizziness, sleep disorders, headaches, paresthesias and hallucinations;
• disorders associated with the epidermis and subcutaneous layer: rash and urticaria;
• disorders of the gastrointestinal tract: nausea, tenesmus, diarrhea, loss of appetite, abdominal pain of a spastic nature, vomiting, and an increase in the effects of hepatic isoenzymes;
• others: increased temperature, fatigue and epidermal itching.

Overdose

Poisoning with the medication can trigger stool disorders, anorexia, ataxia and vomiting. Symptoms of overdose appear quite rarely, even in the case of the use of large portions of the drug.

In the case of violations, gastric lavage is often performed, and sorbents are taken and symptomatic actions are taken. In addition, it is necessary to monitor the work of the cardiovascular system and respiratory system.

[6]

Interactions with other drugs

The drug is not used in combination with theophylline or levamisole (pyrantel leads to potentiation of toxicity of these substances).

Nemotsid cannot be used in combination with piperazine (because it weakens the therapeutic effect of the first).

[7]

Storage conditions

Necocide is required to keep in a closed place from small children. Temperature values are standard for drug substances.

[8], [9]

Shelf life

Nemotsid tablets can be used within a 4-year term since the sale of the pharmaceutical product. Shelf life taken inside the suspension is 36 months.

Application for children

Suspension is not prescribed to babies up to six months, and tablets - to persons younger than 3 years.

[10]

Analogs

Analogs of drugs are substances Helmintox or Pirantel.

[11], [12]