Nazonex

Nasonex is a SCS for topical use. Like other drugs from this category of drugs, it has anti-allergic and anti-inflammatory properties.

[1], [2]

Indications Nazonex

Among the indications for the prescription of the medicine:

• prevention against exacerbation of seasonal allergic rhinitis (in severe or moderate degree). It is recommended to begin prophylactic procedures before the flowering period of plants causing allergies begins (for 2-3 weeks);
• elimination of the all-the-year-round or seasonal rhinitis of allergic nature for children from 2 years old, and also for adults;
• treatment of the chronic form of sinusitis in the acute stage in adults (this category includes elderly patients), and in addition to this 12+ year old children. Spray can be used as an addition to the main treatment process.

Release form

Produced in the form of a nasal spray in plastic bottles with a volume of 18 g (enough for 120 doses). In the package 1 bottle with a lid, and in addition a nozzle-sprayer.

Pharmacodynamics

The medicine acts by slowing the release of the conductors of inflammation. Reduces the concentration of inflammatory exudate inside the inflammatory focus, preventing the marginal accumulation of neutrophilic granulocytes (they are involved in the process of creating an inflammatory reaction). As a result, lymphokine production is reduced, and the process of macrophage migration is slowed down - as a result, the speed of granulation and infiltration processes is weakened.

In addition, the drug slows the development of an immediate allergic response (decreasing the release rate of the conductors (which provoke the inflammatory process, and also suppress the synthesis of eicosatetraenoic acid) from the mast cells).

[3], [4], [5]

Pharmacokinetics

In case of proper intranasal use of the drug, its bioavailability in the hematopoiesis system is less than 0.1%. It should also be noted that even high-tech methods for determining substances in blood serum do not allow detection of Nazonex. Biotransformation of the active substance occurs in the liver.

[6], [7]

Dosing and administration

To eliminate the allergic form of the common cold (year-round / seasonal), the dosage for children 12+ years, and with them and the adult is 2 sprays per each nostril (a day is enough for the first time - in total for the day, approximately 200 micrograms of medication will be obtained). In case of symptoms of improvement, the dose should be reduced to 100 mcg (one spray spray). During the day, you can consume a maximum of 400 μg of medication (that is, a maximum of 4 sprays per 1 nostril).

For children 2-11 years of age, the dosage is 50 micrograms per day (for 1 nostril). Thus, a total of 100 μg of the drug is administered per day.

The positive effect of spray application begins to manifest after 12 hours - there are noticeable signs of improvement.

To eliminate the symptoms of exacerbated chronic sinusitis, the drug is applied in an amount of 100 μg twice a day (2 sprays per each nostril). In general, a dosage of 400 micrograms is obtained per day. In this case, the daily maximum is 800 μg - 4 sprays per each nostril twice per day. After achieving the desired effect, the dosage of the drug should be reduced.

Before the procedure, you need to shake the bottle with the spray.

Use Nazonex during pregnancy

A thorough testing regarding the use of drugs during pregnancy has not yet been carried out. In general, the drug has extremely low bioavailability when administered intranasally, but it is still better not to use Nazonex without acute necessity during lactation and pregnancy.

It is necessary to carefully monitor the work of the adrenal glands in newborns, whose mothers, while pregnant, used Nazonex - this is necessary to avoid the possible development of hypofunction.

Contraindications

Among the contraindications:

• children age less than 2 years;
• tuberculosis of respiratory organs;
• not cured diseases of respiratory organs (they may have a viral, fungal or bacterial nature);
• individual intolerance of the elements of the medicine;
• A recent surgery on the nose or his injury.

[8],

Side effects Nazonex

During the treatment of year-round or seasonal allergic rhinitis, the patients developed such adverse reactions: in adults - the development of pharyngitis, nosebleeds, severe irritation of the mucosa, and in addition burning in the nose; in children, in addition to bleeding and irritation of the mucosa, sneezing and the appearance of headaches were observed.

When using the spray as an additional drug during the treatment of aggravated chronic sinusitis, similar reactions occurred. But it should be noted that in this case bleeding from the nose developed extremely rarely, were weakly expressed, and passed independently.

In single situations, treatment with Nazonex caused an increase in the level of IOP (intraocular pressure), as well as perforation of the septum of the nose.

[9], [10]

Overdose

An overdose can occur as a result of continued joint use of the drug with other drugs from the GCS group. In this case, the most noticeable sign of the disorder will be the symptoms of suppression of the function of the hypothalamic-pituitary adrenal system.

[11], [12]

Interactions with other drugs

In the case of the combination of Nazonex with the drug Loratadin, no adverse reactions occurred. Investigations of interaction with other drugs were not performed.

[13]

Storage conditions

The drug is required to be kept in standard conditions for all medicines. Temperature regime: 2-25 degrees.

[14],

Shelf life

Nazonex is allowed to use for 3 years from the date of manufacture of the spray.