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Nazofan
Last reviewed: 03.07.2025
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Nasofan is a topical nasal glucocorticoid with an external mode of action.
Indications Nazofan
Indications for use are pollinosis (such as hay fever or allergic rhinitis) - the drug can be both a therapeutic and a prophylactic agent.
Release form
Available as a nasal spray in 120 or 150 dose bottles. Each pack contains 1 spray bottle.
Pharmacodynamics
The active component of the drug, fluticasone, has anti-edematous and anti-inflammatory properties.
The anti-inflammatory effect is achieved by suppressing the synthesis of cytokines and nitric oxide, and in addition, by reducing the activity of genes responsible for the production of proteins and enzymes that provoke inflammatory processes.
The antiallergic effect is achieved by reducing the sensitivity of nerve endings to the influence of histamine, as well as reducing nonspecific hyperreactivity. The drug helps to normalize the function of mast cells, and also prevents the release of inflammatory conductors.
Fluticasone is related to receptors located on the nasal mucosa; it is able to inhibit the process of secretion by the glands of the nasal cavity, and also relieves swelling, as a result of which breathing through the nose becomes easier.
Pharmacokinetics
The drug has a local effect, so systemic absorption will be insignificant even if the spray is accidentally swallowed due to leakage through the nasopharynx. After intranasal administration of the drug at a daily dose of 200 mcg, daily fluctuations in the substance cortisol do not change.
Fluticasone has a significant binding to plasma proteins, and it binds to albumin up to 91%. The substance is metabolized in the liver, where it is converted from fluticasone propionate to an inactive breakdown product of the carboxylic acid. Excretion occurs with bile.
Dosing and administration
Nasofan is only allowed to be used intranasally. Before administering the 1st dose, press the nozzle 6 times to get the medicine into the cavity of the sprayer. If the spray is stored without use for more than 7 days, a new dose can be administered only after pre-filling the nozzle by several empty presses.
Adult patients and children over 12 years of age are prescribed 2 sprays per nostril once a day (the dose is 200 mcg). It is advisable to carry out the procedure in the first half of the day. In rare situations, it may be allowed to carry out 2 procedures per day with a 12-hour break (the daily dose is 400 mcg).
As a preventive measure, a maintenance daily dosage of 100 mcg is used - 1 spray in each nostril once a day. In case of exacerbation of the disease, the dosage should be increased to the therapeutic one. A maximum of 400 mcg is allowed per day - 4 sprays in each nostril.
Children aged 4-12 years are recommended to do 1 spray in each nostril once a day (100 mcg). In rare cases, you can do 1 spray per day with a 12-hour break (this gives a dosage of 200 mcg). You can take no more than 200 mcg per day - in the amount of 2 sprays in each nostril. With a long course of treatment, the minimum permissible dosages are used. It is necessary to observe the regularity of the procedures.
The treatment course with Nasofan spray usually lasts about 6 weeks.
Use Nazofan during pregnancy
Nasofan should not be used during lactation or pregnancy. Use is only permitted in cases where there is an urgent need.
Contraindications
Among the contraindications:
- individual intolerance to the active component or other elements of the drug;
- children under 4 years of age.
Side effects Nazofan
Occasionally, side effects may occur, manifested in the form of dryness or irritation of the mucous membranes inside the nasopharynx with the nasal cavity, and in addition, perforation of the nasal septum, ulcerative defects on the skin or mucous membrane, nosebleeds, as well as the appearance of an unpleasant odor or taste.
There is a possibility of an anaphylactic reaction, as well as bronchial spasm and swelling in the nasopharynx, if there is an individual sensitivity to the drug.
From the side of the central nervous system, the reaction may manifest itself in the form of headaches. Among other symptoms, an increase in intraocular pressure, the development of cataracts or glaucoma are distinguished - mainly due to prolonged use of the drug in large doses.
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Interactions with other drugs
When Nasofan is combined with P450 hemoprotein inhibitors (such as ritonavir), the level of fluticasone in the blood increases significantly, which increases the strength of its side effects - due to this, a powerful suppression of adrenal function occurs.
Erythromycin, and in addition to it ketoconazole, slightly increase the pharmacological activity of the active component of Nasofan, as a result of which the side effects of the drug are enhanced, but at the same time they still do not disrupt the function of the hypothalamic-pituitary system of the adrenal glands.
Storage conditions
The spray must be kept in standard conditions for medicines; the temperature should not exceed 25 degrees.
Shelf life
Nazofan can be used for 3 years from the date of manufacture of the spray. After opening the bottle - no more than 3 months.
Attention!
To simplify the perception of information, this instruction for use of the drug "Nazofan" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.