, medical expert
Last reviewed: 11.04.2020

All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.

We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.

If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.

Naxojin is a derivative of nitroimidazole. Used for amebic dysentery, as well as other protozoal infections.

Indications of the naxojina

It is indicated for the elimination of infectious processes provoked by the vaginal trichomonas, and also in the treatment of amoebic dysentery, giardiasis, vaginitis (provoked gardnerella vaginalis), and acute form of gingivitis Vincent.

Release form

Produced in tablets, 6 pieces inside the bottle. One package contains 1 bottle of pills.


The drug is a chemotherapeutic agent that destroys the vaginal Trichomonas and the rest of the simplest microbes (such as intestinal lamblia, Lamblia intestinalis and dysentery amoeba). In addition, Naxojin works on the following anaerobes: bacteroidids fraigilis and gardnerella vaginalis.

The minimum level of trichomonasic effect varies in the range of 0.3-3 μg / ml.


The drug has a high absorption rate after oral administration.

With a triple intake of 1 g of drugs (3 consecutive use with an interval of 12 hours), the level of the substance in the body reaches 16 μg / ml 3 hours after the first dose. After 25 hours, this figure is 28 μg / ml, and after the last use it is 7.5 μg / ml.

Excretion of the active ingredient mainly occurs in the kidneys. Inside the vaginal discharge and urine, the level of the substance and its major degradation products is several times greater than the trichomonocidal concentration.

With a three-time use of drugs at a dose of 1 g (three doses at intervals of 12 hours), the medication within the vaginal discharge, which was determined on the 24th, 48th, and 72nd hour, was 129, 95 , as well as the 4th mkg / g.

Use of the naxojina during pregnancy

It is forbidden to prescribe medication to pregnant women (in particular, this applies to the period of the 1st trimester), as well as to lactating women, since it is capable of mutagenic effects on the fetus or the baby.


Among the contraindications:

  • intolerance to any of the constituent elements of the drug;
  • the presence of the patient's CNS or blood (in severe form);
  • severe degree of liver or kidney failure;
  • children age less than 3 years.

Side effects of the naxojina

Usually the medication is transferred fairly well, and the side effects listed below are weak or medium, and therefore it is not necessary to cancel the drug taking in case of their development. Using Naxojin right after eating, you can minimize the risk of negative consequences.

Among the possible violations noted heartburn, as well as nausea. Occasionally there is dizziness, diarrhea, plaque on the tongue, a feeling of drowsiness, vomiting, and besides this rash on the skin, dryness of the oral mucosa and a sensation in the mouth of the taste of metal. Stomatitis or glossitis may develop, darkening of the color of urine and transient leukopenia of moderate severity are observed.

When you use metronidazole (the drug has a similar composition with Naxojin) occasionally appeared information about the development of pseudomembranous form of colitis. In addition, metronidazole caused neuropathy (tingling sensation in the limb region, as well as numbness) and epileptiform cramps associated with the use of drugs in large doses or with a long therapeutic course.


Dosing and administration

The medicine is consumed inside, immediately after a meal.

With trichomoniasis, the adult dosage is 2 g (or 4 tablets) in one dose, immediately after a meal. Also, the dosage can be distributed 3 times per day (with an interval of 12 hours) to 1 g (2 tablets) or 3 times 250 mg (0.5 tablets each). Duration of treatment - 5-7 days. Children's dosage is 15 mg / kg in 3 doses per day (the period of therapy lasts 5-7 days).

With amoebic dysentery, the adult dose is 500 mg 2 times a day for 5-10 days. The children's dose is 20 mg / kg per day in two doses in the period of 5-10 days.

With giardiasis, the adult dose is 500 mg (1st pill) with admission 2 times a day in the period of 5-7 days. Children's doses are 15 mg / kg with two doses per day for 5-7 days.

In infectious processes, provoked gardnerella vaginalis, adult dosages amount to 1 tablet (500 mg) twice a day during the first week or 2 g for one use.

In the acute form of Vincent's gingivitis, the size of the adult dose is equal to the first pill (500 mg) 2 times per day in the period of 2 days.

trusted-source[2], [3]


Signs of overdose are such violations: discomfort in the gastrointestinal tract (the occurrence of vomiting, heartburn, diarrhea and nausea) and dizziness. In addition, neurologic manifestations may develop - tingling in the limbs, numbness, seizures, and paresthesia.

To get rid of the disorders, you will need gastric lavage and treatment aimed at eliminating pathological signs.

Interactions with other drugs

Nimorazole is able to increase the anticoagulant effect of warfarin, and together with this reduces the clearance rates of lithium and phenytoin.

Plasma values of the drug are reduced when combined with phenobarbital. When combined with cimetidine, this indicator, on the contrary, increases.

In the case of drug use, along with alcoholic beverages, the development of a disulfiram-like reaction is possible.

trusted-source[4], [5], [6], [7]

Storage conditions

Keep the medicine in a place inaccessible to young children. The temperature values are not more than 25 ° C.

trusted-source[8], [9], [10]

Shelf life

Naxojin is allowed to be used in the period of 5 years from the date of release of the medicinal product.



To simplify the perception of information, this instruction for use of the drug "Naxojin" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

You are reporting a typo in the following text:
Simply click the "Send typo report" button to complete the report. You can also include a comment.