It is forbidden to combine Nalgezin with aspirin and other NSAID medicines, as this increases the likelihood of developing negative effects.
Combined use with cholestyramine or antacid agents can inhibit the absorption of naproxen, although this does not affect the amount of this substance.
Combination with cardiac glycosides can cause an exacerbation of heart failure, reduce the rate of glomerular filtration, and in addition increase the indices of SG inside the blood.
After using mifepristone, it is recommended to delay the intake of naproxen for 8-12 days, since this drug can weaken the effect of the latter.
Caution is required when the drug is combined with corticosteroids, because this combination can increase the likelihood of bleeding, as well as ulcers in the gastrointestinal tract.
The active substance of the drug can worsen the process of gluing together platelets, resulting in longer bleeding time. This property needs to be considered when determining the duration of the bleeding period, as well as during combined use with anticoagulants.
It is forbidden to combine the medicine with naprosin, since this drug contains the same active ingredient (naproxen).
The results of tests conducted on animals showed that when a combination of Nalgezin and quinolones in humans, the risk of developing seizures increases.
Because naproxen almost the whole is synthesized with plasma protein, it must be carefully combined with derivatives of sulfonylurea or hydantoin.
The drug is able to reduce natriyuretic properties of furosemide, and in addition antihypertensive effect of antihypertensive drugs.
The combined use of Nalgezin with lithium drugs increases the plasma values of the latter.
Like other drugs included in the category of NSAIDs, naproxen is able to reduce the antihypertensive properties of propranolol, as well as other β-blockers. Together with this, it increases the likelihood of developing kidney failure in people who additionally use ACE inhibitors.
Combined use with the substance probenecid prolongs the half-life of the active component of Nalgezin, and besides it increases its plasma level in the body.
Combined drug taking with a drug, cyclosporine can increase the likelihood of developing functional problems with the kidneys.
In vitro tests, it was possible to determine that the combined use of the drug with zidovudine increases the plasma indices of the latter.
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