Mezim forte

Mezim forte is a polyenzyme medication.

Indications Mezima forte

It is used together with poorly digestible, unusual, as well as fatty and vegetable food. It is also used for bloating, which occurs due to the above-described disorders.

Release form

The pharmaceutical substance is produced in tablets - 10 or 20 pieces inside a cell package.

Pharmacodynamics

Pancreatin (powder extracted from the pancreas) includes excretory enzymes of the pancreas - amylase with lipase, and in addition chymotrypsin with trypsin. They participate in the processes of digestion of carbohydrates with fats, as well as proteins.

Such powder is not absorbed inside the gastrointestinal tract, it is excreted with feces, and the main part of the substance is denatured and split inside the digestive tract under the influence of bacteria with digestive juices. The main factor of effectiveness is the enzymatic activity of lipase, and along with this, the activity of trypsin. At the same time, the amylolytic effect is significant only during the treatment of cystic fibrosis, because even in the case of a chronic type of pancreatitis, the processes of splitting food polysaccharides occur without disorders.

The tablet coating does not have enteric properties. At gastric pH values of less than 4, lipolytic activity is inactivated.

Dosing and administration

The drug should be taken in a dosage of 1-2 tablets, with food. The tablets are not chewed, but washed down with plain water (1 glass is enough). Depending on the type of food used, you can additionally take 2-4 tablets of the drug.

The serving size of Mezim forte can be changed and selected individually.

The duration of the therapeutic cycle is selected by the attending physician, individually for each patient.

Use Mezima forte during pregnancy

The use of the medication during breastfeeding or pregnancy is permitted only when the doctor assesses the benefit from it as more likely than the risk of complications in the fetus or infant.

Contraindications

Among the contraindications:

• the presence of intolerance to pork pancreas powder (or intolerance to pork), component E 122 or one of the components of the medication;
• acute stage of pancreatitis or exacerbation of the chronic form of this disease;
• intestinal obstruction of an obstructive nature.

Side effects Mezima forte

Side effects include:

• immune disorders: signs of intolerance, including sneezing, rashes, bronchial spasms and lacrimation, as well as skin hyperemia, a feeling of weakness or heat, urticaria, itching, Quincke's edema and tachycardia;
• digestive disorders: abdominal discomfort, vomiting, flatulence, diarrhea, constipation, abdominal pain, nausea and intestinal obstruction;
• other symptoms: due to the content of component E 122, patients may experience allergic reactions.

Overdose

In case of poisoning with medication, the patient may experience the development of hyperuricosuria or hyperuricemia.

When such disorders appear, symptomatic measures are carried out.

Interactions with other drugs

The introduction of medications containing powder obtained from the pancreas can provoke a weakening of the absorption of vitamin B9, which sometimes requires its additional intake.

The effect of orally administered hypoglycemic agents (eg, miglitol or acarbose) may be weakened when combined with Mezim forte.

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Storage conditions

Mezim forte should be stored in a place closed to children. Temperature marks – within 25°C.

Shelf life

Mezim forte can be used for a period of 3 years from the date of production of the pharmaceutical substance.

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Application for children

Mezim forte is not prescribed to children under 3 years of age.

Analogues

The analogs of the drug are Pancreatin, Creon, Mikrazim with Pancreatin forte, and also Pangrol, Mezim with Penzital and Ermital with Pancreatin.