Mesoderm

Mezoderm is a dermatological drug from the group of corticosteroids.

[1], [2], [3], [4], [5], [6], [7]

Indications Mesoderm

It is used in the case of the development of dermatoses, which are sensitive to SCS (such as psoriasis ), or in the initial phases of treatment in patients with atopic eczema.

Release form

The release of the drug substance is realized in the form of a cream, in a tube with a capacity of 15 or 30 g. Inside the box is 1 such tube.

[8], [9], [10]

Pharmacodynamics

Betametazol is an active element of the drug; This is an artificial GCS. Demonstrates antiallergic, as well as anti-inflammatory and antipruritic activity.

After treatment of the epidermis with a cream, a local narrowing of the vessels, the disappearance of itching and suppression of the release of inflammatory conductors occur. In addition, there is a slowdown in the activity of the enzyme hyaluronidase and strengthening the strength of vascular membranes.

Because the drug is made on the basis of the cream, it also has a moisturizing and softening effect on the epidermis.

[11], [12], [13], [14]

Pharmacokinetics

Betamethasone is a means of GCF fluorinated nature, because of which it is extremely limited absorbed into the systemic blood flow through the epidermis. The intensity of absorption can significantly increase with inflammation or damage to the epidermis, when its protective functions are impaired.

[15], [16], [17], [18], [19], [20], [21]

Dosing and administration

Use Mezoderm cream is necessary only in the external way - for local processing.

The drug is applied with a thin layer, light rubbing movements - it is necessary that the cream covered the entire affected area. It is necessary to repeat this procedure 2-3 times a day, until symptoms of improvement appear. After that, you need to use the medicine only once a day. You can also alternate the use of cream with another drug, which has a different active ingredient (apply them every other day).

It is not recommended to use the drug for more than 3 months (or to treat too large areas of the epidermis - more than 20% of the body area). When the size of the treatment area of the cream exceeds 10% of the entire epidermis, the mesoderm can be used for a maximum of 7 days. Do not cover the treated areas with plaster or dressings.

After weakening the signs of the disease, it is required to replace the medicine with another corticosteroid, which has a less pronounced therapeutic intensity.

The duration of therapy and the size of the dosage portions the doctor chooses personally for each patient. Often, the medication is used for a maximum of 21 days.

[25], [26], [27], [28], [29], [30]

Use Mesoderm during pregnancy

There is no information regarding the safety of using the cream during pregnancy (especially in the first trimester), and in addition, whether the drug can be eliminated with mother's milk. Because of this, mesoderm is contraindicated in the 1st trimester. At the same time, at later stages of gestation, the drug can be used if the patient's condition is extremely serious.

If you need to apply the cream during lactation, for the period of therapy breastfeeding should be abandoned.

Contraindications

The main contraindications:

• the presence of intolerance associated with the action of one or more elements of the drug;
• viral infections, among which are diseases caused by vaccination;
• epidermal viral pathologies (herpes or chickenpox, as well as herpes zoster);
• rosacea;
• dermatitis on the face;
• bacterial dermatosis, among which are epidermal lesions provoked by syphilis or tuberculosis;
• lesions caused by fungal activity;
• the presence of ulcerative lesions or erosions on the skin;
• frostbite or burns;
• eels;
• rashes or other epidermal lesions located near the eyes - the drug cannot be used to treat ophthalmic disorders.

It is forbidden to cover the places treated with cream with plaster or hermetic dressings, as well as to apply the substance on too large areas of the skin.

[22], [23], [24]

Side effects Mesoderm

In persons with severe hypersensitivity, the cream may cause intolerance symptoms. In addition, there is a risk of overwhelming influence on the adrenal cortex.

Among the most common side effects (epidermis and subcutaneous layer): folliculitis, acne, hypertrichosis, burning sensation, dryness, irritation, itching and redness. In addition, there is also a rash (for example, similar in appearance to acne), striae, hypopigmentation, atrophy of certain areas of the epidermis, dermatitis or secondary infection (especially when applied under a cast or bandage), telangiectasia and maceration of the epidermis.

Overdose

When applied to the epidermis of an excessively large amount of cream or with prolonged use it may develop systemic effects. In this case, suppression of pituitary-adrenal activity is noted and adrenal insufficiency of a secondary nature occurs. It is also possible the development of acute manifestations of hypercortisolism (often treatable), among which is the cushingoid.

In such situations, you need to carry out symptomatic procedures. With long-term use of drugs, it is recommended to perform a gradual cancellation.

[31], [32], [33], [34]

Interactions with other drugs

The mesoderm can potentiate the effect of other medicines that fall into the category of GCS drugs.

[35], [36], [37], [38], [39]

Storage conditions

The mesoderm is required to be kept under standard conditions for medication. It is forbidden to freeze the cream.

[40], [41]

Shelf life

Mezoderm can be used for a 5-year term from the date of manufacture of the pharmaceutical agent.

[42]

Application for children

There is only limited information regarding the safety of using drugs in pediatrics. Given that the child has a smaller total surface of the body, as well as a thinner epidermal layer than an adult, there is a big risk of the active element of the cream acting on the adrenal glands and pituitary. In this regard, the drug is not used in children.

[43]

Analogs

Analogues of drugs are the substances Beloderm, Metizolon, Soderm with Betazon, Advantan, Betamethasone with Kutiveyt, and also Betliben, Sterokort and Celestoderm-B.

[44], [45], [46], [47], [48], [49]