Melitor

Melitor has an antidepressant therapeutic effect.

The active element of the drug is the substance agomelatine, which selectively increases the release of norepinephrine with dopamine. The drug is a selective agonist of MT1 as well as MT2 terminations and a selective antagonist of 5-HT2c terminations.

The drug has no effect on cholinergic, benzodiazepine, as well as adrenergic and dopaminergic endings. Does not change the blood levels of serotonin. In addition to the anti-depressive effect, there is also a thymoanaleptic effect.

Indications Melitora

It is used in the case of the development of depressive episodes, accompanied by sleep disorders.

Release form

The release of the drug substance is produced in tablets of 25 mg.

[1], [2], [3], [4]

Pharmacodynamics

The medicine helps to restore the phases of sleep, as well as the process of melatonin release. In addition, it accelerates falling asleep and contributes to prolonged and high-quality sleep, not interrupted by awakenings; It should be noted that along with this, the drug does not cause the development of daytime sedative effects. Agomelanin has a longer term than that of melatonin, the term half-life, as well as a higher affinity index for melatonin endings.

It is extremely important that the drug has almost no negative manifestations of serotonergic (tremor, anxiety, headaches, impotence, insomnia and dizziness) and adrenergic nature (dry oral mucous membranes, elevated blood pressure values and constipation).

In volunteers, Melitor did not lead to the development of a negative impact in relation to weight, memory, sexual activity and blood pressure level. In addition, the drug does not cause addiction and does not lead to the appearance of withdrawal syndrome.

[5], [6], [7]

Pharmacokinetics

The drug is well absorbed by penetrating the gastrointestinal tract. Bioavailability values are around 3% (while women are slightly higher than men). Bioavailability is increased when using oral contraception. Cmax values of the active element are observed after 1-2 hours. The drug has high levels of protein synthesis.

Exchange processes take place inside the liver.

Approximately 80% of drugs are excreted through the kidneys in the form of non-active metabolic elements. The term half-life is equal to 1-2 hours.

[8], [9], [10], [11]

Dosing and administration

The medication is taken orally - the tablet is swallowed, not chewed, washed down with plain water. You can use the medicine without consuming food, but when negative signs associated with the gastrointestinal tract appear, it is recommended to be taken with food.

The standard daily dose of drugs is 25 mg (1 single dose). In the absence of a noticeable result after the 14th day of treatment, the portion is increased to 50 mg. Daily dosage is used for 1 application, in the evening, before bedtime.

The duration of the cycle is selected by the doctor, taking into account the intensity of the disease. In the case of depression, this course can last more than six months. After completion of therapy is not observed withdrawal. During treatment, you need to monitor the work of the patient's liver.

[18], [19], [20]

Use Melitora during pregnancy

You can not use Melitor when breastfeeding or pregnancy.

Contraindications

Among the contraindications:

• disruption of the liver;
• severe drug intolerance;
• lactose intolerance;
• older people with signs of dementia;
• use in combination with ciprofloxacin or fluvoxamine.

Caution is required when used in people who work with life-threatening machinery or drive a vehicle, as well as in alcohol abusers.

[12], [13], [14], [15]

Side effects Melitora

Often there are such side effects: migraine, nightmares, drowsiness or insomnia, headaches, anxiety and dizziness. In addition, stomach pains, vomiting, obstipation or nausea appear and the transaminase index increases. There may also be severe fatigue, pain in the back and hyperhidrosis.

Occasionally, paresthesia, itching, eczema, visual disturbances and suicidal thoughts appear.

Most of these disorders disappear after 14 days from the start of therapy.

[16], [17],

Overdose

In theory, the appearance of such signs is possible: gastric pain, agitation, severe fatigue, tension, drowsiness and anxiety.

Melitor has no antidote; symptomatic intervention is required.

[21], [22], [23], [24]

Interactions with other drugs

Fluvoxamine has a slowing effect on the metabolic processes of the active component of drugs, because of which the term of its half-life is prolonged.

It is necessary to use the drug very carefully in combination with propranolol, estrogen, enoxacin and grepafloxacin.

Melitor does not change the indicators of drugs synthesized with intraplasma protein.

It does not interact with paroxetine, theophylline, benzodiazepines, fluconazole, and lithium substances.

It is forbidden to use with alcoholic beverages.

[25], [26], [27], [28], [29], [30]

Storage conditions

Melitor can be stored at temperature values in the range of 18-25 ° C.

[31], [32], [33],

Shelf life

Melitor is allowed to apply for a 24-month term from the date of sale of the drug substance.

[34], [35], [36],

Application for children

Not prescribed in pediatrics until the 18th anniversary.

[37]

Analogs

Analogs of drugs are Agomelatin and Valdoxan.

[38], [39], [40], [41], [42], [43], [44], [45]

Reviews

Melitor is usually used in the case of depressions, in which there are sleep disturbances and anxiety, and in addition, in the case of hypertonic VSD, accompanied by asthenic anxiety symptoms. Patients leave quite different reviews regarding the effectiveness of the drug.

All patients note that the medication helps regulate the sleep cycle, while its sedative effects do not lead to the development of daytime sedation. Of the minuses, there is a weakening of concentration when you are driving, as well as weak headaches during the first 7 days of use.

Some commentators consider the medicine to be effective, but there are also those to whom it did not help much. Such differences depend on many factors, including the intensity of depression, sensitivity to drugs and so on. In addition to medications, it is recommended to prescribe psychotherapy - going to sessions with a psychotherapist. This helps to improve the effect of therapy.

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