Medical expert of the article
New publications
Preparations
Medoclav
Last reviewed: 03.07.2025
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Medoclav is a complex antimicrobial drug with a wide range of therapeutic activity.
Indications Medoclava
The drug in the form of injection lyophilisate and tablets is used in people suffering from infections caused by the action of microbes that are sensitive to its active elements:
- infections in the upper and lower respiratory tract, as well as in the ENT organs (this includes acute forms of diseases and chronic, recurring ones);
- diseases affecting the organs of the urogenital system, as well as gynecological infections;
- pathologies affecting joints, epidermis, soft tissues and bones.
In addition, the drug can be used in dentistry – for the treatment of dentoalveolar abscesses.
Lyophilisate for parenteral injection fluids is prescribed to prevent the development of complications after surgical procedures.
Release form
The drug is produced in tablets of 0.5 g/125 mg, in the amount of 8 pieces inside a blister pack, 2 packs inside a box. It is also produced in tablets of 875 mg/125 mg, in the amount of 7 pieces inside a pack, 2 blisters in a pack.
It is also available as a lyophilisate for injection parenteral liquid, in 1.2 g vials. There are 10 such vials in a box.
Pharmacodynamics
Amoxicillin has a bactericidal effect and demonstrates effectiveness against infections caused by the activity of gram-negative and -positive microbes.
Clavulanate, which is a component of the drug, protects amoxicillin from the destructive effects of β-lactamases, increases the range of amoxicillin's influence and significantly reduces the number of resistant bacteria.
In addition to gram-positive and -negative aerobes and anaerobes, the drug has an effect on diseases caused by pale treponema, chlamydia, Borrelia burgdorferi and Leptospira icterohaemorrhagiae.
[ 3 ]
Pharmacokinetics
After oral administration of the drug, the active ingredients are absorbed at high speed in the gastrointestinal tract. Cmax values of amoxicillin are recorded after 1-1.5 hours after administration of the medication.
The active ingredients of the drug penetrate well into tissues and fluids, and also penetrate the hematoplacental barrier. These elements undergo metabolism and are then excreted unchanged and in the form of metabolic products - mainly through the kidneys.
The half-life of amoxicillin is approximately 75-80 minutes, and that of clavulanate is approximately 60-70 minutes.
Dosing and administration
Scheme of using lyophilisate for parenteral administration of drugs.
The drug is made into a liquid administered through infusions and intravenous injections. Intramuscular administration of the drug is prohibited. The medication is administered by jet over 3-4 minutes, and through a dropper – over a period of at least half an hour.
To prepare a liquid for intravenous jet injection, dissolve the lyophilisate from 1 vial in injection water (20 ml). The prepared liquid must be used immediately.
For intravenous administration through a dropper, it is necessary to dissolve the lyophilisate in a certain amount of a suitable solvent and then add it to a compatible infusion fluid (0.1 l).
The following infusion substances are allowed to be used: injection water, 0.9% NaCl solution (after adding Medoclav, such solutions remain stable for 4 hours), Ringer lactate, potassium chloride solution, and NaCl infusion fluid (after adding Medoclav, the medication remains stable for 3 hours).
The prepared solution must be administered immediately, and any unused residue must be disposed of.
During treatment, the patient's clinical condition should be monitored. The recommended doses given are calculated based on amoxicillin.
The dosage size for an adult is generally 1000 mg of amoxicillin administered at intervals of 8 hours.
The prophylactic dosage (in the case of surgical operations) is also often 1000 mg of amoxicillin, which is administered before the use of anesthesia.
When performing an operation that lasts more than 1 hour, in addition to administering 1000 mg of the drug before anesthesia, the same dose of amoxicillin should be administered over the next 24 hours.
A maximum of 5000 mg of amoxicillin may be administered per day.
If the patient develops an infection after surgery, a full course of treatment with the drug must be completed.
The duration of use of the drug is usually a maximum of 2 weeks, but the attending physician may extend the therapy, taking into account the clinical condition of the patient.
People with renal dysfunction and CC values within 10-30 ml/minute are often prescribed 1000 mg of the drug, and then they are transferred to the use of 500 mg of the drug with administration at intervals equal to 12 hours.
People with renal CrCl less than 10 ml/min (including those on hemodialysis) are most often given 1000 mg of the drug first, then switched to 500 mg of amoxicillin, administered at intervals of 24 hours.
People on hemodialysis may need additional medication after the dialysis procedure.
People who have liver dysfunction do not need to adjust portion sizes, but they should constantly monitor liver function and, if necessary, reduce the dosage of the drug or stop taking it.
For children weighing over 40 kg, the dosages intended for adults are used.
For children from 3 months to 12 years of age, the drug is often administered in a dose of 25 mg/kg, with intervals between administrations equal to 6-8 hours.
Children weighing more than 4 kg should take the medicine in the doses recommended for all children over 3 months of age.
Infants under 3 months of age are often prescribed 15-25 mg/kg of the substance at intervals of 8 hours.
Newborns are often given 30 mg/kg of the drug, at intervals of 12 hours.
Mode of administration of the drug in tablet form.
The medication is taken orally; the tablet should not be crushed, chewed or divided before use. During treatment, you should drink enough fluid to reduce the likelihood of crystalluria. To reduce the risk of negative symptoms associated with the gastrointestinal tract, you should take the tablets at the beginning of a meal.
For adults, the most common prescription is to take 1 tablet of 0.5 g/125 mg at intervals of 12 hours.
Adults with severe infections should take 1 tablet of 875 mg/125 mg at intervals of 12 hours, or 1 tablet of 0.5 g/125 mg at intervals of 8 hours.
A maximum of 3 tablets of the drug with a volume of 875 mg/125 mg are allowed per day.
People with kidney problems and CC values below 30 ml/minute are prescribed only the 0.5 g/125 mg form:
- with CC values within the range of 10-29 ml/minute, take 1 tablet of the medicine at intervals of 12 hours;
- if the CC level is below 10 ml/minute (this includes people on hemodialysis), take 1 tablet at intervals of 24 hours;
- People undergoing hemodialysis should take an additional 1 tablet of the drug after completing the dialysis procedure.
The tablets should be used for no longer than 14 days, but the course of treatment can be extended as prescribed by the attending physician.
Use Medoclava during pregnancy
It is completely forbidden to use the medicine in the 1st trimester. In the 2nd or 3rd trimesters, it is used only under strict medical supervision and after assessing the possible benefits and risks.
Medoclav is used with caution during lactation. No adverse effects on infants whose mothers breastfed during treatment with this drug have been reported (only isolated cases of allergic symptoms have been observed - with such a reaction, breastfeeding should be discontinued for the duration of therapy).
Contraindications
Main contraindications:
- the presence in the patient of strong sensitivity to antibiotics from the cephalosporin and penicillin series;
- people who have developed liver problems or jaundice when taking clavulanate or amoxicillin;
- use in people with Filatov's disease, lymphocytic leukemia, and also with bronchial asthma and polyposis.
Caution is required when using the drug in people with kidney or liver problems. It is also prescribed with caution to patients who are drivers or operate potentially life-threatening mechanisms.
Side effects Medoclava
The use of the medication may lead to the appearance of some side effects:
- disorders of the cardiovascular system and hematopoietic system: hemolytic anemia, leuko-, thrombocyto- or neutropenia, as well as agranulocytosis and increased PTI values. After parenteral administration of the substance, thrombophlebitis may appear at the injection site;
- lesions affecting the central and peripheral nervous systems: headaches, hyperactivity or dizziness. There are reports of seizures, mainly in people who took the drug in large doses;
- liver and gastrointestinal tract dysfunction: nausea, hepatitis, diarrhea, jaundice, vomiting and increased liver enzyme levels. Children may develop colitis or dyspepsia symptoms. If diarrhea begins, you should stop taking the drug and consult your doctor;
- signs of allergy: epidermal itching, angioedema, urticaria, TEN, Stevens-Johnson syndrome, vasculitis, anaphylaxis and generalized form of pustulosis of exanthematous origin (in the acute stage);
- Others: oral or vaginal candidiasis, tubulointerstitial nephritis and crystalluria.
If negative symptoms appear due to the use of Medoclav, you should contact your doctor, who will decide whether it is advisable to continue using the drug.
Overdose
Using the drug in excessively large doses can provoke the occurrence of negative reactions in the gastrointestinal tract, as well as a disorder of the EBV values. Along with this, insomnia, severe agitation and convulsions can be noted. Using too high doses also sometimes causes the occurrence of renal failure and crystalluria.
The drug has no antidote. In case of intoxication, it is necessary to stop using the drug and perform symptomatic measures. In addition, it may be necessary to perform procedures that maintain the values of EBV.
In case of severe overdose, hemodialysis procedures are performed.
[ 10 ]
Interactions with other drugs
It is prohibited to combine the drug with probenecid, because this leads to a significant prolongation of the half-life of amoxicillin and increases the likelihood of negative symptoms and intoxication.
The combination of the drug with allopurinol may potentiate the possibility of the appearance of allergic symptoms on the epidermis.
Diuretics, non-narcotic analgesics and allopurinol with phenylbutazone increase plasma drug levels.
Medoclav can weaken the absorption of estrogens and reduce the effectiveness of oral contraception.
When combining the substance with warfarin or acenocoumarol, it is necessary to monitor the PT values.
Antimicrobial drugs from the tetracycline category and other bacteriostatic medications weaken the therapeutic effectiveness of the drug.
The use of the drug may provoke the appearance of a false-positive response in the Coombs test, as well as false indicators regarding the glucose reaction in urine when using the Benedict reagent.
Medoclav potentiates the toxic effects of methotrexate.
It is prohibited to combine the drug with disulfiram.
Laxatives, glucosamine, antacids and aminoglycosides can reduce the absorption of medication through the intestines.
Storage conditions
Medoclav must be stored in moisture-proof places at temperatures not exceeding 25°C.
Shelf life
Medoclav can be used within 24 months from the date of manufacture of the therapeutic drug.
Application for children
The tablets should not be used to treat children under 12 years of age.
Parenteral administration of drugs should be carried out with caution in newborns (especially premature infants).
Analogues
The analogs of the drug are Augmentin, Panclav, Amoxiclav with Amoxil and Flemoklav Solutab.
[ 13 ]
Reviews
Medoclav is considered an effective antibiotic. According to reviews, it helps well with otitis and tonsillitis - the next day after taking the medicine, there is a decrease in ear pain and an easier swallowing process.
Attention!
To simplify the perception of information, this instruction for use of the drug "Medoclav" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.