Medoclava

Medoblase is a complex antimicrobial drug with a large range of therapeutic activity.

Indications Meddlaka

The drug in injection lyophilizate and tablets is used in people who suffer from infections caused by the action of microbes that are sensitive to its active elements:

• infection in the upper and lower part of the respiratory ducts, as well as in the ENT organs (this includes acute forms of diseases and chronic, having a recurrent nature);
• diseases affecting the organs of the urogenital system, and in addition to this infection of a gynecological nature;
• pathologies affecting the joints, epidermis, soft tissues and bones.

In addition, the drug can be used in dentistry - for the treatment of abscesses of dentoalveolar nature.

Lyophilizate for parenteral injection fluids is prescribed to prevent the development of complications after surgical procedures.

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Release form

The drug is produced in tablets with a volume of 0.5 g / 125 mg, in an amount of 8 pieces inside the blister pack, 2 packs inside the box. It is also produced in tablets with a volume of 875 mg / 125 mg, 7 of them inside the package, 2 blisters in a pack.

Also implemented in the form of lyophilizate for injectable parenteral fluid, in bottles with a capacity of 1.2 g. In the box - 10 such bottles.

Pharmacodynamics

Amoxicillin has a bactericidal effect and shows efficacy in infections caused by the activity of gram-negative and-positive microbes.

Clavulanate, a component of the drug, protects amoxicillin from the damaging effect of β-lactamases, increases the range of amoxicillin and significantly reduces the number of resistant bacteria.

In addition to Gram-positive and-negative aerobes and anaerobes, the drug has an effect on diseases caused by pale treponema, chlamydia, borrelia of Burgdorfer and Leptospira icterohaemorrhagiae.

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Pharmacokinetics

After oral administration of drugs, the active elements are absorbed at high speed inside the gastrointestinal tract. The Cmax values of amoxicillin are recorded after 1-1.5 hours after using the medication.

The active substances of the medicine pass well into the tissues and liquids, and in addition penetrate the hematoplacental barrier. These elements are metabolized, and then excreted unchanged and in the form of metabolic products - mainly through the kidneys.

The half-life of amoxicillin is approximately 75-80 minutes, and clavulanate is about 60-70 minutes.

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Dosing and administration

Scheme of using lyophilizate for parenteral drug administration.

From the drug substance, a liquid is injected through infusion and intravenous injection. Intramuscular injection of drugs is prohibited. In the jet method, the medication is administered during 3-4 minutes, and through a dropper - in a period of at least half an hour.

To make liquid for jet intravenous injection, it is necessary to dissolve the lyophilizate from the 1st vial in injection water (20 ml). The finished liquid must be used immediately.

With IV administration through the dropper, it is necessary to dissolve the lyophilizate in a certain amount of a suitable solvent, and then add it to a compatible infusion fluid (0.1 L).

It is allowed to use the following infusion substances: injection water, 0.9% NaCl solution (after the addition of Medoclave such solutions remain stable for 4 hours), Ringer lactate, potassium chloride solution, and infusion liquid NaCl (after addition in it Medoklava the drug remains stable for 3 hours).

The prepared solution must be introduced immediately, and the residues that have not been used should be disposed of.

During the treatment it is necessary to monitor the clinical condition of the patient. The sizes of the recommended recommended portions are made after recalculation for amoxicillin.

The size of the medicament portion for an adult is generally 1000 mg of amoxicillin administered at intervals of 8 hours.

The size of the prophylactic dosage (in the case of performing surgical operations) is also often 1000 mg amoxicillin, which is administered before the use of anesthesia.

In an operation that lasts more than 1 hour, in addition to administering 1000 mg of LS, before the anesthesia, the same portion of amoxicillin should be administered for another 24 hours.

For the day allowed to enter a maximum of 5000 mg of amoxicillin.

If after the operation the patient has an infection, you need to complete a complete treatment cycle using drugs.

The duration of the use of the drug is usually a maximum of 2 weeks, but the attending doctor can prolong the therapy, given the clinical condition of the patient.

People with disorders of renal activity and QC values within 10-30 ml / minute are often prescribed 1000 mg of the drug, and then they are transferred to use 500 mg of LS with the introduction at intervals of 12 hours.

People who have a kidney QC level of less than 10 ml / minute (including those who are on hemodialysis) are most often prescribed first 1000 mg of the drug and then transferred to use 500 mg of amoxicillin, which are administered at intervals of 24 hours.

Persons who are on hemodialysis may need to administer the medication additionally - after the dialysis procedure.

People who have a disorder in the liver do not need to adjust the size of portions, but it is necessary to constantly monitor the liver activity and if there is a need to lower the dosage of the drug or to cancel it.

Children weighing more than 40 kg use doses intended for adults.

Children from 3 months of age and up to 12 years of age often use the drug in a dose of 25 mg / kg, with intervals between administrations equal to 6-8 hours.

Children weighing more than 4 kg should use the medicine in portions that are recommended for all children over 3 months of age.

Infants, whose age does not exceed 3 months, often prescribe the introduction of 15-25 mg / kg of substance with intervals equal to 8 hours.

Newborns often use 30 mg / kg of medication, with intervals equal to 12 hours.

The mode of application of drugs in tableted form.

The medication is used orally; A tablet before use can not be grinded, chewed or divided. During treatment, you need to drink a sufficient amount of liquid to reduce the likelihood of the appearance of crystalluria. To reduce the risk of negative symptoms associated with the gastrointestinal tract, you need to drink pills at the beginning of the meal.

For adults, the first tablet with a volume of 0.5 g / 125 mg is usually administered at intervals of 12 hours.

Adults with severe stages of infection should take 1 tablet of 875 mg / 125 mg at intervals of 12 hours, or 1 tablet of 0.5 g / 125 mg at intervals of 8 hours.

For a day, a maximum of 3 tablets of drugs with a volume of 875 mg / 125 mg is allowed.

Persons with problems in kidney function and CC values below 30 ml / minute are assigned exclusively the form 0.5 g / 125 mg:

• at QC values within 10-29 ml / minute take the first pill of medication at intervals of 12 hours;
• at a QC level below 10 ml / minute (this includes people on hemodialysis), they take 1 tablet at intervals of 24 hours;
• people who are on hemodialysis should take an additional 1-well drug pill after the completion of the dialysis procedure.

Use the pill should not be longer than 14 days, but the treatment course can be extended with the appointment of the treating doctor.

Use Meddlaka during pregnancy

It is completely forbidden to use the medicine on the 1st trimester. In the 2nd or 3rd trimesters, it is used exclusively under strict medical supervision and after assessing the possible benefits and risks.

When lactating Medoblava is used cautiously. Negative effects on infants whose mothers were breastfed when treated with this drug were not recorded (only a single occurrence of allergy symptoms was observed - this reaction should be abandoned for the period of therapy).

Contraindications

The main contraindications:

• presence in the patient of strong sensitivity in relation to antibiotics from a number of cephalosporins and penicillins;
• people in whom the use of clavulanate or amoxicillin caused the appearance of disorders in the work of the liver or the development of jaundice;
• use in persons with Filatov's disease, lymphatic leukemia, and in addition to asthma and polyposis.

Caution is required when using drugs in people with kidney or liver problems. Also, with caution, it is prescribed to patients who are drivers, or manage potentially life-threatening mechanisms.

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Side effects Meddlaka

The use of medication can lead to the appearance of some side-effects:

• disorders in the SSS and hematopoietic system: hemolytic form of anemia, leuko-, thrombocytopenia or neutropenia, as well as agranulocytosis and elevation of PBI values. After parenteral administration of the substance at the site of injection, thrombophlebitis may appear;
• lesions affecting the operation of the central nervous system and PNS: headaches, hyperactivity or dizziness. There are data on the appearance of seizures - mainly in people taking the drug in large portions;
• violations of the liver and gastrointestinal tract: nausea, hepatitis, diarrhea, jaundice, vomiting and an increase in liver enzymes. Children may develop colitis or symptoms of dyspepsia. If diarrhea begins, you should stop using the drug and consult your doctor;
• signs of allergy: epidermal itching, angioedema, urticaria, TEN, Stevens-Johnson syndrome, vasculitis, anaphylaxis, and generalized form of exanthematous pustules (in acute stage);
• Other: candidiasis in the mouth or vagina, tubulointerstitial nephritis and crystalluria.

If there are negative signs due to the use of Medoblava, it is necessary to contact your doctor who decides whether it is advisable to continue using the drug.

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Overdose

The use of medicines in excessively large portions can trigger the occurrence of adverse reactions in the gastrointestinal tract, and in addition, the disruption of VEB values. Along with this, there may be insomnia, severe arousal and convulsions. The use of too high dosages also sometimes causes the appearance of deficiency of renal function and crystalluria.

There is no antidote for the drug. In case of intoxication, you must abolish the use of drugs and perform symptomatic measures. In addition, it may be necessary to perform procedures that support the VEB values.

In the case of severe overdose, hemodialysis procedures are followed.

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Interactions with other drugs

It is forbidden to combine the drug with probenecid, because this leads to a significant prolongation of the half-life of amoxicillin and increases the likelihood of the appearance of negative symptoms and intoxication.

Combination of medicament with allopurinol may potentiate the possibility of the appearance of allergic symptoms on the epidermis.

Diuretics, analgesics of non-narcotic type and allopurinol with phenylbutazone increase the values of LS within the plasma.

The medloclase can weaken the absorption of estrogens and reduce the effectiveness of oral contraception.

When combining a substance with warfarin or acenocoumarol, it is necessary to monitor the indices of the PTV.

Antimicrobial drugs from the category of tetracyclines and other bacteriostatic medicines weaken the therapeutic effectiveness of the drug.

The use of the drug may provoke the appearance of a false positive response with a Coombs test, and also false indications regarding the reaction of glucose inside the urine with the use of the Benedict reagent.

Meddula potentiate toxic effects on methotrexate.

It is forbidden to combine the medicine with disulfiram.

Laxative drugs, glucosamine, antacids and aminoglycosides can reduce the absorption of medication through the intestine.

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Storage conditions

The medoclave must be kept in places that do not penetrate moisture, at temperature values not exceeding 25 ° C.

Shelf life

The medoclave can be used within 24 months of the manufacture of the therapeutic drug.

Application for children

Do not use tablets to treat children under the age of 12.

Parenteral drug administration should be performed with caution in newborns (especially preterm infants).

Analogues

Analogues medicine are medicines Augmentin, Panclav, Amoxiclav with Amoxilom and Flemoclav Solutab.

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Reviews

Medoblava is considered an effective antibiotic. Judging by the reviews, it is good for otitis and angina - already the next day after taking drugs, weakening of pain in the ear and facilitating the swallowing process is observed.