Medical expert of the article
New publications
Preparations
Mediled
Last reviewed: 23.04.2024
All iLive content is medically reviewed or fact checked to ensure as much factual accuracy as possible.
We have strict sourcing guidelines and only link to reputable media sites, academic research institutions and, whenever possible, medically peer reviewed studies. Note that the numbers in parentheses ([1], [2], etc.) are clickable links to these studies.
If you feel that any of our content is inaccurate, out-of-date, or otherwise questionable, please select it and press Ctrl + Enter.
Medichronal has detoxification properties.
Indications Medhronala
It is used to increase the effectiveness of other therapeutic procedures performed with alcoholism:
- alcohol intoxication, withdrawal syndrome;
- prevention of the development of alcoholism of a secondary nature;
- prevention of intoxication.
Release form
The release of the substance is realized in pellets, inside packages of type No. 1, and also No. 2; The kit contains one of each package type. Inside the box there are 1, 7 or 21 sets.
Pharmacodynamics
Medohronal is a complex medicine that helps to reduce the excess of toxic metabolic products (acetaldehyde) of ethanol inside the body.
The drug has detoxification properties; it activates the processes of metabolism, promotes the biosynthesis of catecholamines (among them norepinephrine), thereby potentiating neurotransmitter processes, as well as the function of the cerebral cortex. Along with this, the drug stabilizes the activity of the limbic-reticular complex.
Has a positive effect on liver function, helps to improve sleep and overall well-being.
Attenuation of symptoms of acute alcohol intoxication and manifestations of withdrawal occurs after about 30 minutes after drug use.
Pharmacokinetics
Glycine at high speed is absorbed from the digestive tract. The bioavailability of the substance approaches the 100% mark. The element quickly passes into most of the body's fluids and tissues. The conversion of glycine within the liver is carried out with the participation of glycine oxidase.
Preservative E237 is also absorbed rather quickly inside the intestine. Getting into the body, the substance interacts with acetaldehyde, isolating the conjugates involved in the activity of the citrate cycle, as well as potentiating the synthesis of macroergic ligaments.
Dosing and administration
Use medochronal should be inside, after eating. The granules contained in the bags No. 1 and No. 2 are previously dissolved in plain water (0.2 L). The disposable portion is 28.5 g (total weight of the pellets of 2 packets). To improve the taste of the drug, non-carbonated drinks are allowed to dissolve the substance.
To stop acute withdrawal or intoxication with alcohol, on the first day, 28.5 g of drugs are taken at intervals of 12 hours, and then similar dosing once for the 2nd and 3rd days.
In combination with other drugs for the treatment of chronic alcoholism, as well as the need for secondary prevention, daily intake of 28.5 grams of medication is prescribed for 7 days. The entire treatment course in such cases usually consists of 3 such cycles, between which 3-day breaks occur.
To prevent the likelihood of relapse, it is recommended that after a period of 1.5 months after the end of the therapy, a repeated 1-month treatment cycle be performed. For a year, 1-3 repeat treatment courses for prevention, continuing 1-2 weeks are allowed.
To prevent the development of intoxication can be by taking a one-time dose of medicine 30 minutes before the alleged use of alcohol.
[1]
Use Medhronala during pregnancy
There is no information on the safety of use of medication in pregnant women or lactating women, which is why it can not be prescribed in these periods.
Contraindications
The main contraindications:
- presence of strong sensitivity relative to the components of the drug;
- severe stage of diabetes mellitus;
- decreased values of blood pressure.
Side effects Medhronala
The use of granules can lead to some side effects:
- disorders affecting the activity of the National Assembly: headaches, feelings of irritability or tension, and a decrease in concentration;
- disorders of the digestive function: the appearance of nausea;
- signs of allergies: rashes, hives, or itching.
Overdose
Poisoning with drugs can trigger the development of disorders in the digestive process: flatulence, nausea and diarrhea. In addition, there may be a potentiation of the severity of adverse symptoms.
Symptomatic procedures are performed to correct the violations.
Interactions with other drugs
Glycine weakens the toxic properties of anticonvulsants, antipsychotics, and in addition to these antidepressants.
Combination of the drug with antipsychotics, tranquilizers, and hypnotic drugs leads to stimulation of the retarding effect on HC.
Medichronal can be combined with other medicines used for alcohol dependence (except for disulfiram).
Storage conditions
It must be kept in a closed place from small children. The storage temperature can be a maximum of 25 ° C.
Shelf life
Medichronal can be used within 36 months of the release of the therapeutic agent.
Analogues
The analogues of the medicine are medicines Naltreksin, Biotredin and Antakson with Kolme, and in addition Selincro, Vivitrol, Tetlong with Proprotenom 100 and Acidum S.
Reviews
The medohronal receives rather conflicting reviews from the patients who received it. Many note that when taking drugs before drinking alcohol, there is a complete absence of the expected effect, and the drug itself causes only a hypnotic effect.
Attention!
To simplify the perception of information, this instruction for use of the drug "Mediled" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.