Medexol

Medexol is an anti-inflammatory medication used to treat ophthalmic diseases.

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Indications Medecolla

It is used to treat noninfectious lesions of the cornea, conjunctiva and anterior ocular segment (allergic or inflammatory).

Can be used for inflammation after surgical procedures.

Release form

Release of the medicine is made in the form of a suspension for eye drops, inside the flasks-droppers, having a volume of 10 ml. Inside the pack - 1 such a bottle.

Pharmacodynamics

Corticosteroids are highly effective in treating inflammation affecting the eyes. GCS have an anti-inflammatory effect, inhibiting the adhesive molecules of the vessels inside the endothelial cells, as well as COX 1 or 2, and in addition the process of secretion of cytokines. This allows to reduce the production of inflammatory conductors and suppress leukocyte adhesion to the vascular endothelium, thus preventing their passage into the inflamed eye tissues.

Dexamethasone demonstrates pronounced anti-inflammatory activity with reduced mineralocorticoid effect (in comparison with some other steroids) and is considered one of the most powerful anti-inflammatory elements.

Pharmacokinetics

Ophthalmic values of the bioavailability of dexamethasone in the local treatment of the eye were determined in people who had previously had an operation to remove cataracts.

Peak values of about 30 ng / ml, the component reaches in the intraocular fluid; This happens after 2 hours. After that, there is a decrease in indicators with a half-life, lasting 3 hours.

Dosing and administration

Medexol is used exclusively for ophthalmic procedures. Vial with droplets should be shaken before use.

At the beginning of treatment for acute or severe stage of inflammation, 1-2 drops of drug should be used - instilled into the conjunctival sac of the infected eye at intervals of 0.5-1 hour.

With the development of a positive reaction, the batch is reduced to the introduction of the same 1-2 drops, but at intervals of 2-4 hours.

Later, the dosage can be reduced to the 1st drop, digested 3-4 times a day (if this amount is sufficient to control inflammation).

Chronic forms of inflammation are treated with 1-2 drops of the drug at intervals of 3-6 hours.

In the case of allergies or mild inflammation, 1-2 drops of LS are added at intervals of 3-4 hours until the desired result is achieved.

It is premature to stop treatment. During therapy, the IOP should be monitored regularly.

After the instillation, you must gently close your eyes or occlude the nasolacrimal segment. Such measures allow weakening the systemic absorption of the drug, thereby reducing the risk of common negative symptoms.

When using other local ophthalmic drugs during treatment with Medexol, you should adhere to the intervals between their applications, which are 10-15 minutes.

Use of drops for problems with renal / hepatic activity.

Studies on the use of medication in people with similar disorders have not been conducted. However, a weak systemic absorption of a substance in the local use of drugs makes it possible to assign it to such patients without adjusting the dosage.

Scheme of drug use.

Wash hands before starting the procedure. Next, throw back the head, pull back the lower eyelid, then bring the tip of the dropper to the eye and drip into the cavity formed a drop of the drug, gently pressing on the bottle.

Do not touch the eyelids, eyelids, or other surfaces with a dropper, because as a result, infection of the drops may occur.

After instillation, you need to release the eyelid, close your eyes, and then gently press your finger inside the corner of the eye (near the nose).

At the end of the procedure, the bottle with drops is covered with a protective cap.

If the first time did not manage to drip a drop in the eye, repeat the procedure. If, on the contrary, too much medicinal substance has been dripped, it is required to rinse the eye with warm running water and not bury it until the time of the next dosage.

If the dosage was missed, you should drip a single dose immediately, once it was remembered. But if by that time the turn of the new dose has already approached, the previous one should be skipped, having dripped only the new one. Do not administer a double dose of medication.

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Use Medecolla during pregnancy

When pregnant, the medication can be used exclusively in situations where its use is expected to benefit the mother rather than harm the fetus.

It is recommended to give up breastfeeding for the duration of therapy.

Contraindications

Among the contraindications:

• presence of high sensitivity for dexamethasone or other medicamentous elements;
• provoked by the activity of simple herpes acute keratitis of superficial nature, chicken pox and cowpox, and in addition other diseases in the conjunctiva and cornea caused by the action of viruses;
• an untreated eye infection of bacterial origin;
• eye infections of mycobacterial origin, provoked, inter alia, by acid-fast microbes (Koch's stick, Hansen's bacillus or Mycobacterium avium);
• fungal pathology in the field of eye structures;
• an untreated eye infection of purulent nature in the acute stage, which, like other diseases provoked by the activity of bacteria, is able to be masked or potentiated under the influence of GCS.

Corticosteroids should not be used after removing (without complications) a foreign object from the eye or if a person has traumas or infections limited by the superficial epithelial zone of the cornea.

Side effects Medecolla

The use of drops may trigger the appearance of certain side effects:

• test results: sometimes the IOP values increase;
• lesions affecting the work of the National Assembly: there may be dizziness;
• disorders of ophthalmic nature: often marked pain in the eye area and damage affecting the cornea. Sometimes there may be eye irritation. Occasionally corneal perforation occurs, glaucoma or cup-like cataract develops, and in addition, visual field disorder, visual deterioration and ocular itching; In addition, there are allergic symptoms in the eye area. Uncomfortably, there may be discomfort in the eyes, keratitis, mydriasis or ptosis, as well as an unusual feeling inside the eyes. Possible appearance of ocular hyperemia, visual fogging, staining or erosion of the cornea;
• pathology of infectious genesis: occasionally develop eye infections (there is an exacerbation or a complication occurs).

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Overdose

When the drug is intoxicated after a local application, it is necessary to wash its excess with simple warm water.

Interactions with other drugs

The use of Medexol may provoke an additional increase in IOP if it is used in combination with eye dilating eye drops (such as atropine or other anticholinergic drugs) that can also increase IOP values.

When combined with other local ophthalmic medicines, it is required to maintain between their applications intervals of at least 5 minutes.

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Storage conditions

Medexol is required to be kept out of the reach of small children. Temperature indices are not higher than 25 ^o C.

Shelf life

Medexol can be used within 36 months from the date of manufacture of the drug. The opened bottle has a shelf life of 1 month.

Application for children

There is no information on the safety and efficacy of Medexol in pediatrics.

Analogues

The analogues of the medication are Dexamethasone, Ozirdex Implant, Pharmadox, Dexapos with Oftan Dexamethasone, and Maxidex.

Reviews

Medexol copes well with the treatment of conjunctivitis, which is allergic in nature - quickly and effectively eliminates redness, itching and souring in the eye area. Most reviews of the drug indicate its positive effect.