Mebendazole

Mebendazole is an anthelminthic drug.

[1], [2], [3], [4]

Indications of the mebendazole

It is used to eliminate such diseases as enterobiosis with gnathostomosis, ankylostomiasis with trichurosis, ascariasis with alveococcosis, angiovulosis with capillarosis, and in addition helminthiases of mixed type, echinococcosis, trichinosis, nematodes of multiple nature and teniodosis.

[5]

Release form

The release is carried out in tablets, which are placed in blister plates, 6 pieces per each. Inside a separate pack - 1 such blister.

[6], [7], [8]

Pharmacodynamics

The mechanism of drug exposure is based on the irreversible disorder of glucose removal processes, which causes depletion of the glycogen content inside the body of the parasite. In addition, the drug slows the binding of tubulin within the cells and the synthesis of ATP elements.

[9], [10], [11]

Pharmacokinetics

When administered orally, the drug is almost not absorbed inside the digestive tract. Excretion occurs with feces. A small part of the substance, after penetration into the blood, is subjected to protein synthesis (90%) inside the plasma, and in addition to hepatic metabolism.

[12], [13], [14], [15]

Dosing and administration

Take Mebendazole tablets should be taken orally, washed down with plain water.

When enterobiosis: should be taken a one-time dose of 100 mg. If there is a high risk of secondary invasion, an additional 100 mg should be taken after 2-4 weeks. Also, the treatment course is required to pass through all persons who have been in contact with the patient at this time.

With shadeosis, mixed types of helminthiases, ascariasis with earth scabies and angiovilleosis with trichurosis, take a dosage of 100 mg twice a day (in the morning and in the evening) during the 3 days.

[22], [23],

Use of the mebendazole during pregnancy

Most tests have shown that Mebendazole has teratogenic and embryotoxic properties. In pregnancy, especially in the first trimester, it is forbidden to use this medication. Sometimes it is allowed to use during pregnancy, but only in cases where the benefit to the mother is much higher than the likely risk to the fetus.

Contraindications

The main contraindications:

• lactation period;
• Ulcerative form of colitis;
• hypersensitivity to elements of drugs;
• children under the age of 2 years;
• liver disease;
• regional enteritis.

[16], [17], [18]

Side effects of the mebendazole

The taking of tablets can provoke the appearance of such side effects:

• diarrhea and epigastric pain, as well as vomiting;
• leukopenia with eosinophilia and anemia;
• Hypercreatininaemia and increased values of hepatic enzymes;
• hematuria with cylindruria;
• alopecia and allergy symptoms;
• dizziness.

[19], [20], [21]

Overdose

The main signs of poisoning: nausea with diarrhea and vomiting, the development of hepatitis or neutropenia, as well as intoxication of the liver.

It is necessary to perform gastric lavage and give the affected enterosorbents.

[24], [25], [26]

Interactions with other drugs

Mebendazole reduces the insulin requirement in people who have diabetes.

It is forbidden to combine drugs with lipophilic type compounds.

Medications that induce metabolic processes, as well as carbamazepine, reduce the indices of the drug, while cimetidine, on the contrary, increases them.

[27], [28], [29]

Storage conditions

Mebendazole is required to be stored in a place that is closed from children's access, with a temperature reading of a maximum of 25 ° C.

[30], [31]

Special instructions

Reviews

Mebendazole is considered a very effective anthelmintic drug. The reviews demonstrate that if the drug is used correctly, it will be possible to remove the parasites from the body without problems.

[32], [33], [34]

Shelf life

Mebendazole is allowed to be used for 4 years. The drug in the form of Mebendazole Amed can be used in the period of 2 years.

[35],