Mebendazole

Mebendazole is an antihelminthic drug.

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Indications Mebendazole

It is used to eliminate diseases such as enterobiasis with gnathostomiasis, ancylostomiasis with trichuriasis, ascariasis with alveococcosis, angvilliosis with capillariasis, as well as mixed-type helminthiasis, echinococcosis, trichinosis, multiple nematodes and teniasis.

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Release form

The release is carried out in tablets, which are placed in blister strips, 6 pieces each. Inside a separate pack - 1 such blister.

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Pharmacodynamics

The mechanism of action of the drug is based on the irreversible disorder of glucose removal processes, which causes depletion of glycogen content inside the parasite's body. In addition, the drug slows down the binding of tubulin inside cells and the process of synthesis of ATP elements.

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Pharmacokinetics

When administered orally, the drug is almost not absorbed inside the gastrointestinal tract. Excretion occurs with feces. A small part of the substance, after penetrating into the blood, undergoes protein synthesis (90%) inside the plasma, and also liver metabolism.

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Dosing and administration

Mebendazole tablets should be taken orally with plain water.

For enterobiasis: a single dose of 100 mg should be taken. If there is a high risk of secondary invasion, an additional 100 mg should be taken after 2-4 weeks. Also, all persons who have been in contact with the patient at this time should undergo a course of treatment.

For teniasis, mixed types of helminthiasis, ascariasis with scabies and anguillulosis with trichuriasis, take a dosage of 100 mg twice a day (morning and evening) for a period of 3 days.

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Use Mebendazole during pregnancy

Most tests have shown that Mebendazole has teratogenic and embryotoxic properties. During pregnancy, especially in the first trimester, it is prohibited to use this medicine. Sometimes it is allowed to use during pregnancy, but only in cases where the benefit to the mother is much higher than the probable risk to the fetus.

Contraindications

Main contraindications:

• lactation period;
• ulcerative colitis;
• hypersensitivity to drug components;
• children under 2 years of age;
• liver disease;
• regional enteritis.

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Side effects Mebendazole

Taking pills can cause the following side effects:

• diarrhea and epigastric pain, as well as vomiting;
• leukopenia with eosinophilia and anemia;
• hypercreatininemia and increased liver enzyme values;
• hematuria with cylindruria;
• alopecia and signs of allergy;
• dizziness.

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Overdose

The main signs of poisoning are nausea with diarrhea and vomiting, the development of hepatitis or neutropenia, and liver intoxication.

It is necessary to perform gastric lavage and give the victim enterosorbents.

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Interactions with other drugs

Mebendazole reduces insulin requirements in individuals with diabetes mellitus.

It is prohibited to combine drugs with lipophilic compounds.

Drugs that induce metabolic processes, as well as carbamazepine, reduce the drug's indicators, while cimetidine, on the contrary, increases them.

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Storage conditions

Mebendazole should be stored in a place inaccessible to children at a temperature of maximum 25°C.

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Special instructions

Reviews

Mebendazole is considered a very effective antihelminthic drug. Reviews show that if the drug is used correctly, it will be possible to remove parasites from the body without problems.

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Shelf life

Mebendazole is allowed to be used for 4 years. The drug in the form of Mebendazole Ameda can be used for a period of 2 years.

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