Maxigan

Maxigan is a combined drug, which has spasmolytic and analgesic properties.

Indications Maxigan

Among the indications:

• moderate or mild pain due to spasms that appear in smooth muscles - manifested with spasms of the ureter or ureter, as well as colic in the kidneys;
• intestinal, and in addition, biliary colic;
• dysfunction of ZHVP, chronic form of colitis, and in addition postcholecystectomy syndrome;
• Algodismenorea or pathology of organs located in the small pelvis.

The medication can be used for short-term therapy with neuralgia, but also for pain in muscles or joints, and with sciatica.

As an auxiliary medicine for pain developing as a result of performing a diagnosis or in the postoperative period.

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Release form

Produced in the form of tablets or injection solution. Blister plates contain 10, 20 or 100 tablets each, one blister per package. Glass ampoules with a solution have a volume of 5 ml. One cell plate contains 5 ampoules; 1-per cell in the bundle.

[2], [3]

Pharmacodynamics

Analginum is a non-opioid analgesic, a derivative of pyrazolone. Among its properties - painkillers, anti-inflammatory, as well as antipyretic.

Pitophenone hydrochloride has myotropic properties and has a strong enough relaxing effect on smooth muscles in the internal organs.

Bromide fenpiverinia has m-holinonegativnoe impact, which allows him to have an additional soothing effect on smooth muscles.

Three of these substances in combination increase the strength of each other's pharmacological action, which allows the medicine to reduce pain, relax smooth muscles and lower the temperature. 

[4], [5], [6], [7], [8],

Dosing and administration

Maxigan tablets should be consumed orally (for children aged 15 and older) at a dosage of 1-2 tablets 2-3 times per day. A day allowed to use no more than 6 tablets. The duration of the treatment course is a maximum of 5 days.

For children 6-8 years, the dosage is 0.5 tablets, at the age of 9-12 years - three quarters of the tablet, and at 13-15 years - 1-well pill. Frequency of reception - 2-3 times per day.

It is recommended to drink tablets immediately after meals.

The injection drug solution is administered intravenously or intramuscularly. Children from 15 years and adults, in the case of acute colic in severe form, need to administer the medication intravenously (slowly - 1 ml for 1 minute) in a dosage of 2 ml. In case of need, the medicine can be administered again after 6-8 hours.

Intramuscularly the drug is administered 2 times a day in a dosage of 2 ml. For a day you can enter no more than 4 ml. The duration of the treatment course is a maximum of 5 days.

The solution is administered to children (both intravenously and intramuscularly) in accordance with their weight and age.

Children 3-11 months (weight 5-8 kg) can be performed only in / m injections in a dosage of 0.1-0.2 ml.

Children 1-2 years (weight 9-15 kg) dosage iv injection - 0.1-0.2 ml; in / m injections - 0.2-0.3 ml.

Children 3-4 years (weight 16-23 kg) dosage IV in injections - 0.2-0.3 ml; in / m injections - 0,3-0,4 ml.

Children 5-7 years (weight 24-30 kg) dosage iv / in injections - 0,3-0,4 ml; In / m injections - 0.4-0.5 ml.

Children 8-12 years (weight 31-45 kg) dosage iv injection - 0.5-0.6 ml; in / m injections - 0,6-0,7 ml.

Children of 12-15 years (weight 46-53 kg) dosage IV in injections - 0.8-1 ml; in / m injections - 0.8-1 ml.

If necessary, the drug can be re-administered in the same dosage.

[16], [17]

Use Maxigan during pregnancy

The medicine can not be used in the first trimester, and also in the last 6 weeks of pregnancy.

Contraindications

Among the contraindications:

• individual intolerance of drug components (as well as pyrazolone derivatives);
• suppression of hematopoiesis in the bone marrow;
• pronounced form of hepatic or renal insufficiency;
• deficiency of G6PD in the body;
• presence of tachyarrhythmia, angina in severe form, decompensated form of CHF;
• glaucoma of the closed type;
• hypertrophy of the prostate (with the presence of clinical signs);
• intestinal obstruction;
• collapse, and besides this megacolon;
• the period of lactation.

In / in the use of drugs is prohibited for infants under 3 months (or at weights up to 5 kg). Tablets are prohibited for children under the age of 5 years.

Caution is necessary when used by patients with bronchial asthma, and besides with hepatic or renal insufficiency, the Sumter's triad, propensity to lower blood pressure, intolerance to NSAIDs.

[9], [10], [11], [12]

Side effects Maxigan

Among the side reactions:

• allergy: itching and rashes on the skin; occasionally may develop hives, anaphylaxis, edema Quincke; single-syndrome Lyell or Stevens-Johnson;
• organs of the digestive system: single - dryness in the oral cavity, as well as a burning sensation in the epigastric region;
• organs of the central nervous system: single - dizziness and headaches, as well as paresis of accommodation;
• organs of the hematopoietic system: thrombocyto- and leukopenia, and in addition agranulocytosis (among its symptoms - chills, fever, swallowing problems, sore throat, vaginitis, stomatitis, and proctitis);
• organs of the respiratory system: spasms of the bronchi (especially in patients who are predisposed to this);
• organs of the cardiovascular system: lowering the level of blood pressure and tachycardia;
• organs of the urinary system: occasionally (mainly due to prolonged intake or drug overdose) - development of anuria and oliguria, and in addition also proteinuria and tubulointerstitial nephritis; In addition, urine can acquire a red tint (due to the products of metamizole disintegration); single - problems with urination;
• local reactions: after intramuscular injection at the site of the procedure may appear infiltrates;
• others: single - reduced sweating.

[13], [14], [15]

Overdose

Due to an overdose, there are such manifestations: lowering the level of AD, vomiting with nausea, a feeling of drowsiness, dryness in the mouth, confusion, pain in the epigastrium, a disorder in the kidney or liver, the appearance of seizures and changes in sweating.

As a therapy, it is required to rinse the stomach and drink activated charcoal. If necessary, symptomatic treatment may be performed.

Interactions with other drugs

Due to the combination of Maxigan with other non-opioid analgesics, a mutual increase in the poisoning effect can be observed.

Tricyclics, OK, and also allopurinol have a destructive effect on the metabolic process of metamizole sodium, and in addition increase its toxic properties.

Barbiturates with phenylbutazone and other drugs that induce microsomal hepatic enzymes reduce the effectiveness of the active component of Maxigan.

Due to the combination of the active substance with cyclosporine, the latter's blood levels decrease.

Soothing drugs and tranquilizers increase the strength of the analgesic effect of metamizole sodium.

In the case of combining Maxigan with butyrophenones, substances blocking the histamine receptors (H1), amanatadine, as well as quinidine and phenothiazines, the force of m-holinonegative action may increase.

The combination of Maxigan and ethanol can promote mutual enhancement of their effect on the body.

Due to the combined use of the drug with chlorpromazine or other phenothiazine derivatives, strong hyperthermia can develop.

Metamizole sodium is able to disrupt the association of oral antidiabetic drugs, GCS, as well as indomethacin and anticoagulants (indirect effects) with proteins. Together with this, it also increases their effectiveness.

A combination with cytostatic drugs or thiamisol increases the possibility of developing a patient with leukopenia.

In the case of a compound with drugs blocking the histamine receptors (H2), and besides this, the rate of inactivation of metamizole sodium decreases with codeine and propranol, and its effect on the body increases.

Injection solution should not be mixed in a syringe with any other drug solutions.

[18], [19], [20]

Storage conditions

The medicine must be kept in a place protected from sunlight, moisture, and access to children. Temperature indices in the room should not be more than 25 ° C. 

[21], [22]

Shelf life

Maxigan is allowed to be used for 3 years from the date of manufacture of the medicine.

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