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Maxigezik
Last reviewed: 03.07.2025
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Maxigesic is a combination drug with analgesic and muscle relaxant properties that has a suppressive effect on spinal reflexes.
Indications Maxigezik
Indications for use of the drug include:
- acute pain (such as toothache, muscle pain and headache, as well as muscle inflammation and radiculopathy);
- soft tissue rheumatism;
- rheumatoid arthritis;
- spondyloarthritis;
- deforming spondylitis;
- exacerbation of gout;
- osteoarthritis;
- primary form of dysmenorrhea;
- inflammation of the appendages (salpingo-oophoritis);
- otitis and pharyngotonsillitis.
Release form
Available in tablet form. One blister contains 10 tablets. A cardboard envelope contains 1 blister.
Pharmacodynamics
Paracetamol has analgesic and antipyretic properties, as well as a moderate anti-inflammatory effect. The mechanism of pain relief occurs by preventing the synthesis of prostaglandins - suppressing the enzyme cyclooxygenase.
Diclofenac has a strong anti-inflammatory and analgesic effect, as well as a moderate antipyretic effect. These effects are achieved by suppressing cyclooxygenase (this is the main enzyme in the metabolism of eicosatetraenoic acid - the precursor of PG, which are the main causative agents of the development of pain and inflammation, as well as fever). Analgesic properties are formed by blocking the process of PG synthesis - indirectly or directly through the central nervous system. The drug helps reduce pain (in motion and at rest) that occurs after surgery or injury, and in addition, relieve swelling that occurs due to inflammatory processes. As a result of prolonged use, a desensitizing effect may develop. A lasting result begins to appear after 1-2 weeks of therapy.
Serratiopeptidase is a proteolytic enzyme from the genus Serratia. It breaks down bradykinin and other anti-inflammatory components, thereby reducing swelling.
Pharmacokinetics
After taking the medicine, paracetamol is absorbed in the upper intestine. The substance reaches its peak concentration in the blood serum after 0.5-1.5 hours. The metabolism process occurs in the liver. Excretion is with urine. The half-life is 1-3 hours.
Diclofenac is completely absorbed through the gastrointestinal tract after oral administration. Plasma protein binding is 99%, and the substance reaches its peak concentration after 1-2 hours. The level of diclofenac in plasma depends on the dosage of the drug. It passes into the synovial fluid, and its peak concentration in it is reached later than in the blood plasma (by 2-4 hours). It is 50% metabolized after the "first pass" through the liver (in the process of hydroxylation with conjugation), resulting in the formation of pharmacologically inactive decay products. The half-life is 1-2 hours, and from the synovial fluid - about 3-6 hours. About 60% of the drug is excreted in the form of decay products through the kidneys, and even less than 1% is excreted unchanged in the urine. The remains in the form of metabolites are excreted from the body with bile.
Serratiopeptidase is completely absorbed from the intestines quite quickly, and usually reaches its peak concentration in the blood plasma 0.5-2 hours after taking the drug. The substance enters the bloodstream as an active enzyme, and is excreted from the body in the same way. It also increases the local concentration of antibiotics, increasing their ability to pass into tissues. As a result, antibiotics, even in the smallest dose, can affect the body for a long time - this makes it possible to avoid the negative effects of taking the drug in large doses.
Dosing and administration
The dosage is selected by the doctor individually for each patient - it depends on the effectiveness of the drug, the course and form of the pathology, as well as the patient's age and tolerance to the drug.
For children 14+ years old and adults – the dosage is 1 tablet 2-3 times a day after meals.
The duration of the treatment course is a maximum of 5-7 days (the duration depends on the dynamics of the symptoms fading). It is allowed to take no more than 3 tablets of the medicine per day.
The medicine should be used in the most effective dosages over a short period of time, taking into account the individual treatment goals for each patient.
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Use Maxigezik during pregnancy
Taking the medicine during pregnancy is contraindicated.
Contraindications
Among the contraindications:
- individual intolerance to the active components of the drug;
- aggravated erosive and ulcerative processes in the gastrointestinal tract;
- disorders of hematopoiesis;
- active alcoholism in chronic form;
- lactation period;
- children under 6 years of age.
Side effects Maxigezik
Among the side effects, the following stand out:
- mainly gastrointestinal disorders (such as vomiting with nausea, pain in the epigastrium, and diarrhea), anemia, agranulocytosis, as well as thrombocytopenia, paresthesia, aseptic pyuria, tubulointerstitial glomerulonephritis and kidney disorders develop; in addition, disorders of hematopoiesis, erythema multiforme and allergies (skin rashes, itching, angioedema and urticaria) are often observed;
- occasionally drowsiness, dizziness with headaches and increased activity of transaminases in the blood serum may occur;
- isolated cases – ulcers or erosions on the gastrointestinal mucosa, bleeding, development of hepatitis or pancreatitis.
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Interactions with other drugs
Due to the combination with digoxin, its concentration in plasma may increase.
Maxigesic reduces the effectiveness of antihypertensive drugs and furosemide.
When combined with potassium-sparing drugs, hyperkalemia may develop.
When combined with GCS and NSAIDs, the risk of gastrointestinal bleeding may increase.
The combination of the drug with cyclosporine, as well as methotrexate, is contraindicated.
Due to the combination of the drug with anticonvulsants, barbiturates, and alcohol, the risk of developing hepatotoxicity increases sharply.
Storage conditions
The medicine must be kept in standard conditions - a dark, dry place, inaccessible to children. Temperature conditions - maximum 25ºС.
Shelf life
Maxigesic is recommended to be used for 3 years from the date of manufacture of the medicine.
Attention!
To simplify the perception of information, this instruction for use of the drug "Maxigezik" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.