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Maksigesik
Last reviewed: 23.04.2024
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Maksigesik is a combined medicine with analgesic and miorelaxing properties, which has a suppressive effect on spinal reflexes.
Indications Maksigesik
Among the indications for drug use:
- acute pains (such as dental, muscular and headaches, and in addition muscular inflammation and radiculopathy);
- rheumatism of soft tissues;
- rheumatoid arthritis;
- spondylitis;
- deforming spondylitis;
- exacerbation of gout;
- osteoarthritis;
- the primary form of dysmenorrhea;
- inflammation of the appendages (salpingoophoritis);
- otitis and pharyngotongzillitis.
Release form
Produced in the form of tablets. In one blister plate, 10 tablets. The cardboard envelope contains 1 blister.
Pharmacodynamics
Paracetamol has analgesic and antipyretic properties, as well as moderate anti-inflammatory effects. The mechanism of anesthesia occurs by inhibiting the synthesis of prostaglandins - suppressing the enzyme cyclooxygenase.
Diclofenac has a strong anti-inflammatory and analgesic effect, as well as a moderate antipyretic. These effects are achieved by suppressing cyclooxygenase (this is the main enzyme of the metabolism of eicosatetraenic acid, the precursor of PG, which are the main pathogens for the development of pain and inflammatory processes, as well as fever). Anesthetic properties are formed by blocking the process of synthesis of PG - indirectly or directly through the central nervous system. The medicine can reduce the pain (in motion and rest) that occurs after surgery or trauma, and in addition to remove the swelling that occurs due to inflammatory processes. As a result of prolonged use, a desensitizing effect may develop. A stable result begins to appear after 1-2 weeks of therapy.
Serratopeptidase is a proteolytic enzyme from the genus of serrations. It cleaves bradykinin, as well as other anti-inflammatory components, thereby reducing puffiness.
Pharmacokinetics
After using the drug, paracetamol absorption occurs in the upper intestine. The peak concentration in the blood serum material reaches 0.5-1.5 hours later. The process of metabolism occurs in the liver. Excretion - together with urine. The half-life is 1-3 hours.
Diclofenac after oral intake is completely absorbed through the digestive tract. Binding to plasma proteins is 99%, and the peak concentration of the substance reaches after 1-2 hours. The level of diclofenac in the plasma depends on the dosage of the drug. It passes into the synovial fluid, and the peak concentration in it reaches later than in the blood plasma (for 2-4 hours). Metabolized to 50% after the "1st passage" through the liver (during hydroxylation with conjugation), resulting in the formation of pharmacologically inactive decay products. The half-life is 1-2 hours, and from synovial fluid - about 3-6 hours. Approximately 60% of the drug is excreted in the form of decay products through the kidneys, and even less 1% - unchanged with urine. Remains in the form of metabolites are excreted from the body together with bile.
Serratiopeptidase quite quickly absorbed completely from the intestine, and the peak concentration in the blood plasma usually reaches 0.5-2 hours after taking drugs. The substance enters the bloodstream in the form of an active enzyme, and is also excreted from the body. It also increases the local concentration of antibiotics, increasing their ability to pass into tissues. Because of this, antibiotics, even in the smallest dose, can affect the body for a long time - this makes it possible to avoid the negative effects of using the drug in large doses.
Dosing and administration
Dosage is selected by the doctor individually for each patient - depends on the effectiveness of drugs, the course and form of the pathology, as well as the age of the patient and its tolerability.
For children 14+ years and adults - the dosage is 1-well a tablet 2-3 times a day after eating.
The duration of the treatment course is a maximum of 5-7 days (the duration depends on the dynamics of the extinction of symptoms). A day is allowed to take no more than 3 tablets of medication.
You need to consume the medicine in the most effective dosages for a short time interval, taking into account individual treatment tasks for each patient.
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Use Maksigesik during pregnancy
Taking a medicine during pregnancy is contraindicated.
Contraindications
Among the contraindications:
- individual intolerance of active components of drugs;
- aggravated erosive-ulcerative processes in the digestive tract;
- disorders of hematopoiesis processes;
- active alcoholism in chronic form;
- lactation period;
- children age less than 6 years.
Side effects Maksigesik
Among the side reactions are the following:
- mainly disorders of the digestive tract (such as vomiting with nausea, epigastric pain, and diarrhea), anemia, agranulocytosis, as well as thrombocytopenia, paresthesia, aseptic pyuria, tubulo-interstitial glomerulonephritis, and kidney disorders; In addition, often there are disorders of hemopoiesis, erythema multiforme and allergies (skin rash, itching, angioedema and urticaria);
- occasionally there may be drowsiness, dizziness with headaches and increased activity of transaminases in blood serum;
- single - ulcer or erosion on the mucosa of the gastrointestinal tract, the appearance of bleeding, the development of hepatitis or pancreatitis.
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Interactions with other drugs
Due to the compound with digoxin, an increase in its concentration in the plasma is possible.
Maksigesik weakens the effectiveness of antihypertensive drugs and furosemide.
When combined with potassium-sparing drugs, it is possible to develop hyperkalemia.
When combined with SCS and NSAIDs, the risk of bleeding in the gastrointestinal tract may increase.
Combination of the drug with cyclosporine, as well as methotrexate is contraindicated.
Due to the combination of drugs with anticonvulsants, barbiturates, and alcohol, the risk of developing hepatotoxicity increases dramatically.
Storage conditions
It is required to keep the medicine under standard conditions - a dark, dry place, inaccessible to children. Temperature conditions - maximum 25ºС.
Shelf life
Maksigesik is recommended to be used for 3 years from the date of manufacture of the medicine.
Attention!
To simplify the perception of information, this instruction for use of the drug "Maksigesik" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.