Before using the medication, a skin sensitivity test is required.
The standard size of the adult dose is 1 g, administered by iv or in / m at intervals of 12 hours. Often, the course of treatment lasts 7-10 days, but with severe forms of infection, longer therapy may be required.
But the methods of administration and dose fluctuate with the sensitivity of pathogenic microbes, the degree of severity of the infectious process, and also with the patient's renal function. The following are recommendations for adult dosages Maxipim:
- infectious processes in the urinary ducts (medium or mild severity) - 0.5-1 g by the method IM or I / O every 12 hours;
- other infections (medium or mild severity) - 1 g IM or IV every 12 hours;
- severe forms of infection - 2 g after every 12 hours;
- very serious forms of infections, as well as those that can be life threatening - 2 g after every 8 hours.
To perform prophylaxis against the emergence of infection due to surgery, you need 1 hour before the procedure to enter 2 g of solution for half an hour (for adults). After the process is completed, add 0.5 g of metronidazole intravenously. It should be noted that metronidazole can not be administered together with Maxipim. Before using metronidazole, the infusion system must be rinsed.
For prolonged operations (more than 12 hours) 12 hours after the 1st dosage, it is required to enter an equal dose of Maxipim repeatedly, also with the subsequent use of metronidazole.
In the presence of functional renal disorders (and also, if the QC value is less than 30 ml / minute), dose adjustment of the drug is required. For adults, they will be:
- the QC value is 30-50 ml / minute - 2 g after every 12 or 24 hours; 1 g after every 24 hours; 0.5 g after every 24 hours;
- level of CK 11-29 ml / minute - 2 g after every 24 hours; 1 g after every 24 hours; 0.5 g every 24 hours;
- the level of QC is less than 10 ml / minute - 1 g every 24 hours; 0.5 g every 24 hours; 0.25 g after every 24 hours;
- at a hemodialysis - on 0,5 g after every 24 hours.
As a result of hemodialysis, approximately 68% of the drug is excreted from the body within 3 hours. At the end of each procedure, it is required to enter the drug again at doses equal to the initial size. In the case of permanent peritoneal dialysis (outpatient) procedures, it is allowed to administer the solution at standard starting doses - 0.5, 1 or 2 g (depending on the severity of the infection process) at intervals of 48 hours.
For infants 1-2 months of age, the medication can be administered solely for life indications - the dose is 0.3 g / kg every 8 or 12 hours (depending on the severity of the infection process). It is required to constantly monitor the condition of the children receiving medication, the weight of which is less than 40 kg.
Children with functional disorders of the kidneys need to lower the dosage, or lengthen the intervals between procedures.
For children over 2 months, the highest dose can not be more than the recommended adult. In children weighing less than 40 kg (with uncomplicated or complicated infectious processes in the urinary ducts (among them pyelonephritis), and in addition, with pneumonia, uncomplicated skin infections and with the empirical therapy of neutropenic fever), the recommended dosage is 0.5 g / kg every 12 hours. For children with bacterial meningitis or neutropenic fever - every 8 hours.
Dosage sizes for children weighing 40 kg are similar to adults.
The drug is injected / in a way either by deep injection intramuscularly. In the second case, you should choose a site of the body with a large muscle - for example, gluteus; outer upper quadrant.