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Magurol
Last reviewed: 03.07.2025
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The cardiovascular drug Magurol is an α-adrenergic receptor blocker.
[ 1 ]
Indications Magurol
The drug Magurol is indicated for the treatment of:
- high blood pressure;
- benign prostatic hyperplasia.
Magurol is often included in combination therapy regimens, along with thiazides, beta-blockers, ATP inhibitors or calcium antagonists.
[ 2 ]
Release form
Magurol is a tablet containing the active ingredient doxazosin mesylate. The tablets are dosed at 2 and 4 mg. The tablets are white in color and round and flattened in shape. There is a notch on one side to allow dosing of the drug.
The blister pack contains 10 tablets and the packaging consists of two blister packs in a cardboard box.
Pharmacodynamics
Magurol is a selective competitive blocker of postsynaptic alpha 1 -adrenoreceptors. The drug promotes the expansion of the peripheral vascular bed - this, in turn, provokes a decrease in OPSS and blood pressure.
The action of Magurol leads to an increase in the coefficient of total cholesterol - HDL, as well as to a decrease in the total amount of triglycerides with cholesterol.
With prolonged treatment with the drug, a reverse development of hypertrophic changes in the left ventricle is observed, platelet aggregation is suppressed, and the content of the plasminogen stimulator in tissue structures increases.
Blocking alpha 1 -adrenergic receptors, which are localized in the stroma and capsule of the prostate, in the isthmus of the bladder activates a decrease in resistance and pressure in the urethra, as well as similar processes in the urethra.
Magurol stabilizes urological dynamics and eliminates signs of benign prostate enlargement.
Pharmacokinetics
After internal administration, the drug is absorbed efficiently: its level in the blood plasma reaches its maximum possible level just 2 hours after taking the tablet.
Magurol is eliminated from plasma in two stages, and the final half-life is 22 hours. This property allows taking a tablet once a day.
In cases of impaired renal function, no significant features in the kinetics of the drug were observed.
The drug is metabolized mainly in the liver, therefore, in case of pathological changes in this organ, Magurol is used very carefully.
About 98% of the active ingredient binds to plasma proteins.
Metabolism occurs primarily through O-demethylation and hydroxylation.
[ 3 ]
Dosing and administration
The medicine Magurol is taken in the morning or in the evening.
- For high blood pressure, the dosage of Magurol is always prescribed individually, on average - from 1 to 16 mg per day. As a rule, treatment begins with a smaller amount of the drug, but if necessary, the dose is increased.
- In benign prostatic hyperplasia, treatment begins with 1 mg of the drug daily. Sometimes the dosage is increased to 2 mg, and then to 4 mg. The maximum possible recommended amount of Magurol is 8 mg. The course of therapy usually lasts 7-14 days.
No dosage adjustment is required for elderly patients.
[ 5 ]
Use Magurol during pregnancy
Animal studies have not found any harmful effects of the drug on the fetus. However, it was noted that the administration of the drug in large doses resulted in a limited chance of fetal survival.
Studies involving pregnant women have not yet been conducted, so it is not possible to state whether Magurol is dangerous or safe for the pregnancy process and for the fetus.
For this reason, the question of the advisability of treating pregnant women with the drug should be decided by the doctor in each specific situation.
It has been proven that the drug penetrates into breast milk, so it is better not to combine treatment with Magurol and breastfeeding.
Contraindications
Magurol has a short list of contraindications. Among them:
- hypersensitivity to quinazoline drugs;
- hypersensitivity to doxazosin or excipients of the tablets.
Side effects Magurol
- Vestibular disorders, nausea, dizziness.
- Swelling, general discomfort, clouding of consciousness.
- Runny nose.
- Feeling of noise in the ears.
- Blurred vision.
- Dyspepsia, thirst, increased gas formation.
- Pain in the body.
- Jaundice associated with bile stasis.
- Allergy.
- Changes in liver function tests.
- Change in body weight.
- Pain in joints, spine, muscles.
- Tremors, numbness in the limbs.
- Sleep disorders, anxiety, depressive states.
- Changes in diuresis, incontinence.
- Erectile dysfunction.
- Cough, shortness of breath, bronchospasm.
- Itching, rashes.
- Redness of the face, fever.
- Lowering blood pressure.
- Pain in the heart, change in heart rhythm.
[ 4 ]
Overdose
Taking a large amount of the drug at one time can cause a sharp decrease in blood pressure. If this happens, the patient should be placed in a horizontal position with his head lower in relation to the body. If necessary, symptomatic drugs are prescribed.
In case of overdose, hemodialysis is considered ineffective.
Interactions with other drugs
The combination of Magurol and other blood pressure lowering agents helps to enhance the effect in a mutual direction.
The combination of Magurol and calcium channel blockers can lead to a significant drop in blood pressure.
Nitrates, general anesthetics, tricyclic antidepressants and ethyl alcohol-based drugs may increase the hypotensive effect of Magurol.
Magurol is well combined with diuretics, furosemide, beta-blockers, non-steroidal anti-inflammatory drugs, antibiotics, antidiabetic drugs and anticoagulants.
Storage conditions
Magurol can be stored in normal room conditions, keeping children away from the storage areas of medicinal products.
Shelf life
Magurol can be stored for up to 5 years.
Attention!
To simplify the perception of information, this instruction for use of the drug "Magurol" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.