Magurol

Cardiovascular means Magurol is a drug-blocker of α-adrenergic receptors.

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Indications Magurol

Medicinal remedy Magurol is indicated for treatment:

• high blood pressure;
• benign prostatic hyperplasia.

Magurol is often included in combined therapeutic regimens, along with thiazides, beta-blockers, ATP inhibitors or calcium antagonists.

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Release form

Magurol is a tablet with an active ingredient of doxazosin mesylate. Tablets are dosed at 2 and 4 mg. The color of the tablets is white, the shape is round, flattened. On the one hand there is a notch for the possibility of dosing the drug.

The blister plate contains 10 tablets, and the package consists of two blister plates in a cardboard box.

Pharmacodynamics

Magurol is a selective competitive blocker of postsynaptic alpha _1- adrenoreceptors. The drug contributes to the expansion of the peripheral vascular bed - this, in turn, provokes a decrease in OPSS and blood pressure.

The action of Magurol leads to an increase in the coefficient of total cholesterol - HDL cholesterol, as well as a decrease in the total number of triglycerides with cholesterol.

Against the backdrop of prolonged treatment with the drug, reverse development of hypertrophic changes in the left ventricle is detected, platelet aggregation is suppressed, and the content of plasminogen stimulant in tissue structures increases.

The blocking of alpha _1- adrenoreceptors, which are located in the stroma and capsule of the prostate, in the isthmus of the bladder activates a decrease in resistance and pressure in the urethra, as well as similar processes in the urethra.

Magurol stabilizes urological dynamics and eliminates signs of benign proliferation of the prostate.

Pharmacokinetics

After internal reception there is a qualitative absorption of a preparation: its level in a blood plasma becomes as much as possible already after 2 hours after the use of a tablet.

From the plasma, Magurol is excreted in two stages, and the final half-life is 22 hours. This property allows one to take the pill once a day.

With impaired renal function, no significant features were observed in the kinetics of the drug.

The metabolism of the drug is mainly carried out in the liver, therefore, with pathological changes of this organ, Magurol is used very carefully.

About 98% of the active component forms a bond with the plasma proteins.

Metabolism occurs mainly through O-demethylation and hydroxylation.

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Dosing and administration

The drug of Magurol is taken in the morning or evening.

• At high blood pressure, the dosage of Magurol is always prescribed individually, on average - from 1 to 16 mg per day. As a rule, treatment starts with a smaller amount of the drug, but if necessary, the dose is increased.
• In benign prostatic hyperplasia, treatment is started with 1 mg of the drug daily. Sometimes the dosage is increased to 2 mg, and then to 4 mg. The maximum possible recommended amount of Magurol is 8 mg. The course of therapy usually lasts 7-14 days.

For elderly patients, dose adjustment is not required.

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Use Magurol during pregnancy

Studies conducted on animals have not detected a harmful effect of the drug on the fetus. However, it was noted that the administration of the drug in large doses led to a restriction of the possibility of survival of the fetus.

Studies involving pregnant women have not been conducted so far, therefore, there is no possibility of asserting a danger, or of the safety of Magurol for the process of pregnancy and for the fetus.

For this reason, the question of the appropriateness of treatment with pregnant women should be decided by the doctor in each specific situation.

The penetration of the drug into the composition of breast milk is proven, therefore it is better not to combine the treatment with Magurol and breast-feeding.

Contraindications

Magurol has a small list of contraindications. Among them:

• hypersensitivity to quinazoline preparations;
• hypersensitivity to doxazosin or auxiliaries of tablets.

Side effects Magurol

• Vestibular disorders, nausea, dizziness.
• Edema, general discomfort, blurred consciousness.
• Coryza.
• Sensation of noise in the ears.
• Blurred vision.
• Dyspepsia, thirst, increased gas formation.
• Pain in the body.
• Jaundice associated with congestion of bile.
• Allergy.
• Change in hepatic parameters.
• Change in body weight.
• Pain in the joints, spine, muscles.
• Trembling, numbness in the limbs.
• Sleep disturbances, anxiety, depressive conditions.
• Change diuresis, incontinence.
• Violations of potency.
• Cough, shortness of breath, bronchial spasm.
• Itching, rashes.
• Redness of the face, fever.
• Decreased blood pressure.
• Pain in the heart, change in the rhythm of the heart.

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Overdose

Taking a large amount of the drug at one time can cause a sharp drop in blood pressure. If this happens, the patient should be given a horizontal position, placing his head lower in relation to the body. If necessary, prescribe symptomatic drugs.

In case of an overdose, hemodialysis is considered ineffective.

Interactions with other drugs

The combination of Magurol and other means that lower blood pressure, contributes to the strengthening of the action in a reciprocal direction.

The combination of Magurol and calcium channel blockers can lead to a marked drop in blood pressure.

Nitrates, preparations for general anesthesia, tricyclic antidepressants and preparations based on ethyl alcohol can cause an increase in the antihypertensive effect of Magurol.

Magurol is well combined with diuretics, furosemide, beta-blockers, non-steroidal anti-inflammatory drugs, antibiotics, antidiabetic drugs and anticoagulants.

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Storage conditions

Magurol can be stored in ordinary room conditions, not allowing children to store storage of medicines.

Shelf life

Magurol can be stored for up to 5 years.