Magnnerot

Magnnerot is a drug that belongs to a group of drugs that affect the course of metabolic processes in the tissues of the human body. Magneroth is one of the drugs with the properties of mineral additives. In this case, Magnnerot is included in the subgroup of drugs, the active component of which is magnesium.

[1], [2], [3], [4]

Indications Magnnerot

Indications for the use of medicine Magnerot in medical practice are as follows:

1. Complex therapy of the following diseases:

• myocardial infarction,
• ischemic heart disease,
• atherosclerosis,
• hyperlipidemia,
• arterial hypertension,
• magnesium-dependent cardiac arrhythmias,
• states caused by spasms (muscle cramps, angiospasms - narrowing of the lumen of blood vessels and so on).

2. Magnnerot is also used for preventive purposes to prevent the appearance of the above diseases and disease states.       

3. Therapy of diseases such as:

• suprarenticular violations of the rhythm of the heart,
• failure of the left ventricle of the heart,
• violation of metabolic processes associated with fats and carbohydrates in the body.

[5], [6], [7], [8], [9]

Release form

The medicine is produced in the form of tablets.

In one tablet of Magneroth's medicine there is:

• the active component - magnesium orotate dihydrate - five hundred milligrams (pure magnesium - 32.8 milligrams);
• additional components - lactose monohydrate, colloidal anhydrous silica, carmelose sodium, microcrystalline cellulose, corn starch, povidone K30, sodium cyclamate, talc, magnesium stearate.

Tablets are packaged in blisters of ten in each.

The drug is issued in a carton in two forms. In one form of the package contains twenty tablets of medicine (or two blisters), and in the other - fifty (or five blisters). In addition, each package has instructions for use.

[10], [11], [12], [13], [14],

Pharmacodynamics

1. is a magnesium preparation that contains this substance in the form of magnesium dihydrate orotate.
2. The important role of magnesium, as a substance, is assigned to the regulation of energy processes in the body. A similar effect of the macroelement was found in the presence of protein, lipid and carbohydrate metabolism. To this list, it is necessary to add the necessary presence of magnesium for the exchange of nucleic acids.
3. Magnesium promotes the suppression of neuromuscular transmission by adjusting the neuromuscular excitation.
4. Magnesium is a natural calcium antagonist.
5. This macrocell takes an active part in the regulation of contractile functions of the myocardium, and is also an indispensable element for the normal functioning of cardiomyocytes.
6. Medication Magneter, thanks to the high content of magnesium is a drug that increases the resistance of the body to stress.
7. Orotic acid, contained in Magnnerot, is a stimulator of cell growth and promotes. 

[15], [16], [17], [18]

Pharmacokinetics

Processing in the body of magnesium orotate dihydrate is carried out exactly inside the cell. The presence of orotic acid in the drug allows to fix magnesium to ATP in the cells of the body.   

1. Slightly more than half of the amount of magnesium consumed in the body takes on a free ionized form. Approximately one third of the substance is able to bind to serum proteins. About thirteen percent of this macronutrient is contained in the body in the form of salts. 
2. Magnesium is able to accumulate such tissues as bone. This also applies to intracellular space.
3. Magnesium ions, getting inside the cells, begin to bind to ATP, RNA and DNA.
4. Orotic acid, contained in the preparation, is able to transform into the body into uridine phosphate, which is an intermediate product of the metabolism of pyrimidine.
5. The active substance of Magnnerot medicine is excreted from the body through the intestines and kidneys, and also with the help of sweat glands.
6. The active component of the drug is distinguished by its penetration through the blood-brain and hematoplacental barriers. The macronutrient magnesium is also found in breast milk.

[19], [20], [21], [22], [23], [24],

Dosing and administration

                                                            Method of administration and dose.

   Long-term use of the Magneroth drug is indicated in the following situations:

When there are symptoms of magnesium deficiency, which are due to the presence in the human body of the following diseases and disease states:

• diseases of the gastrointestinal tract,
• systematic use of food products with a low content of magnesium,
• systematic intake of alcoholic beverages (symptoms of chronic alcoholism), which reduces the reabsorption of magnesium in the renal tubules and increases the excretion of magnesium from the body.

When taking the following types of medicines that can reduce the amount of magnesium in the human body:

• oral contraceptives,
• diuretics,
• muscle relaxants,
• glucocorticoids,
• insulin.

Under conditions that cause an increase in the body's need for magnesium:

• hypodynamia (a violation of the proper functioning of the body's systems, due to low motor activity, and a decrease in the muscle contraction force caused by the same cause)
• persistent and severe stress,
• period of pregnancy in women.

The way of using Magneter is as follows:

• is prescribed taking two medication tablets three times a day,
• the course of treatment is one week,
• then the dosage of Magnnerot is changed to one tablet two or three times a day,
• The changed course of treatment of Magneter is carried out not less than four - six weeks,
• if necessary, therapy with Magnnerot can be repeated.

With cramps that occur at night, the medication is used in the evening for two to three tablets.

The largest daily amount of Magneroth is up to six tablets.

The drug should be consumed one hour before meals. Tablets are washed down with a small amount of water, for example, with one glass.
 

[33], [34], [35], [36], [37]

Use Magnnerot during pregnancy

   Use of the drug Magneroth during pregnancy is as follows:

1. During pregnancy and lactation period, experts recommend taking magnesium preparations, including Magneter.
2. The intake of magnesium preparations is shown to pregnant women and nursing mothers due to a significant increase in the need of the female body in magnesium.
3. In the absence of a sufficient amount of this element in the mother and child, there is a high probability of unforeseen and serious complications in the development of the baby and the state of the woman's health. Also, the lack of magnesium in the body of a pregnant woman can lead to an involuntary interruption of pregnancy.

Contraindications

Contraindications to the use of the medicine Magneter are as follows:

1. The existing hypersensitivity to the components of Magneter.
2. Manifestation of symptoms of lactase deficiency and galactosemia, malabsorption syndrome of glucose-galactose.
3. Contraindicated the use of medication for those patients who have manifestations of hypermagnesemia and hypocalcemia.
4. It is forbidden to use a medication to treat patients with signs of urolithiasis, cirrhosis of the liver with ascites and impaired renal function.
5. The use of Magnnerot is also contraindicated in case of atrioventicular blockade of I-II degree, and also with bradycardia.
6. The drug is not used to treat conditions of magnesium deficiency, as well as diseases caused by this violation of metabolic processes, for the treatment of patients of child age (up to 14 years).
7. Patients who take medication should be as cautious as possible with the management of life-threatening mechanisms (this also applies to the driving of vehicles and cars).

[25], [26], [27]

Side effects Magnnerot

  Taking medicine Magnerot can cause the following side effects in the human body:

1. There may be diarrhea (diarrhea).
2. It is also possible the appearance of signs of irregular stools.
3. With a decrease in the amount of medication that is taken per day, disturbing symptoms disappear.
4. Perhaps the emergence of allergic reactions in the form of rashes on the skin, redness of the skin, itching and burning of affected areas.

[28], [29], [30], [31], [32]

Overdose

• An overdose of Magneter drug causes an increase in the side symptoms, which were described earlier in the previous section.
• If the renal function of the patient taking Magnerot is normal, then the appearance of signs of overdose is not observed or observed in rare cases.
• Magnesium intoxication of the body is characterized by symptoms of a disorder of the central nervous system. These include signs of nausea, vomiting, obstruction of the bladder, constipation, paralysis of the respiratory system.
• Magnesium intoxication can also manifest itself in the symptomatology of cardiac health disorders: worsening of the heart in the form of a decrease in the atrioventricular conduction, as well as the appearance of excitation pulses from the ventricles. Also, the effect of a large amount of magnesium on neuromuscular conduction in the form of a curare-like effect can be observed.
• Magnesium intoxication is neutralized by the introduction of calcium into the body by an intravenous route (from one hundred to two hundred milligrams of Ca2 +). Of the additional funds used the procedure of hemodialysis (the method of extrarenal blood purification), peritoneal dialysis (the method of intracorporal cleansing of the blood) and artificial respiration. 

[38], [39]

Interactions with other drugs

The interaction of medicament Magneter with other drugs is as follows:

• If you take Magnerot with preparations containing iron, this leads to difficulties in assimilating the active substances contained in these medicines.
• Simultaneous reception of Magnnerot and tetracycline gives a similar result - there is a slowdown in the absorption of the active substances of the drug.
• Absorption of the active components of the sodium fluoride preparation is slowed down by the action of Magnnerot, if these medications were taken simultaneously.
• Due to the above-mentioned features of Magnnerot, this medication should be used separately with iron preparations, tetracycline and sodium fluoride. The optimal interval between taking these medications is two to three hours.
• Medication Magnnerot when combined during the reception is able to stimulate the effectiveness of drugs that have a depressing effect on the central nervous system. These drugs include sedatives, tranquilizers and neuroleptics.
• Antihypertensive and antiarrhythmic drugs begin to act with an enhanced effect when combined with the reception of Magneter.
• The use of the medicament Magneter can reduce the risk of the appearance and progression of negative effects for the body, namely, reducing the amount of magnesium that can occur when taking certain medications. These include diuretic drugs, aminoglycosides, cyclosporine, cisplatin, methotrexate, amfotericin and drugs with laxative effect. 

[40], [41], [42],

Storage conditions

The storage conditions for the medicament Magneter are as follows:

1. Magnerot is contained in the original packaging.
2. The drug should be stored at room temperature from 15 to 25 degrees Celsius.
3. The drug should be kept out of the reach of children.
                                                                                     

[43], [44], [45], [46]

Shelf life

   Shelf life of the drug Magnerot - five years from the date of release. It is forbidden to use the drug for treatment after the expiration date.

[47], [48], [49], [50], [51], [52], [53]