Magnerot

Magnerot is a drug that belongs to a group of drugs that affect the course of metabolic processes in the tissues of the human body. Magnerot is one of the drugs with the properties of mineral supplements. At the same time, Magnerot is included in a subgroup of drugs whose active component is magnesium.

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Indications Magnerot

Indications for the use of the drug Magnerot in medical practice are as follows:

1. Complex therapy of the following diseases:

• myocardial infarctions,
• ischemic heart disease,
• atherosclerosis,
• hyperlipidemia,
• arterial hypertension,
• magnesium-dependent cardiac arrhythmias,
• conditions caused by spasms (muscle cramps, angiospasms – narrowing of the lumen of blood vessels, and so on).

2. Magne-rot is also used for prophylactic purposes to prevent the occurrence of the above-mentioned diseases and painful conditions.

3. Therapy for diseases such as:

• supraventricular cardiac arrhythmias,
• left ventricular failure,
• disruption of metabolic processes associated with fats and carbohydrates in the body.

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Release form

The medicine is produced in the form of tablets.

One tablet of the drug Magnerot contains:

• active ingredient – magnesium orotate dihydrate – five hundred milligrams (pure magnesium – 32.8 milligrams);
• additional components – lactose monohydrate, colloidal silicon dioxide anhydrous, sodium carmellose, microcrystalline cellulose, corn starch, povidone K30, sodium cyclamate, talc, magnesium stearate.

The tablets are packaged in blisters of ten pieces each.

The medicine is available in cardboard packaging in two types. One type of packaging contains twenty tablets of the medicine (or two blisters), and the other - fifty (or five blisters). Additionally, each package has instructions for use.

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Pharmacodynamics

1. is a magnesium preparation that contains this substance in the form of magnesium dihydrate orotate.
2. An important role of magnesium as a substance is given to the regulation of energy processes in the body. A similar effect of the macroelement has been revealed in the presence of protein, lipid and carbohydrate metabolism of a person. To this list we must add the necessary presence of magnesium for the exchange of nucleic acids.
3. Magnesium helps inhibit neuromuscular transmission by regulating neuromuscular excitation.
4. Magnesium is a natural calcium antagonist.
5. This macroelement takes an active part in regulating the contractile functions of the myocardium, and is also a necessary element for the normal functioning of cardiomyocytes.
6. The drug Magnerot, due to its high magnesium content, is a medicine that increases the body's resistance to stress.
7. Orotic acid, contained in Magnerot, is a cell growth stimulator and promotes.

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Pharmacokinetics

The body processes magnesium orotate dihydrate inside the cell. The presence of orotic acid in the medication allows magnesium to be fixed to ATP in the body's cells.

1. A little more than half of the consumed amount of magnesium in the body takes the free ionized form. About a third of the substance is capable of binding to serum proteins. About thirteen percent of this macroelement is contained in the body in the form of salts.
2. Magnesium can accumulate in tissues such as bone. This also applies to the intracellular space.
3. Magnesium ions, entering the cell, begin to bind with ATP, RNA and DNA.
4. Orotic acid, contained in the drug, is capable of being transformed in the body into uridine monophosphate, which is an intermediate product of pyrimidine metabolism.
5. The active substance of the drug Magnerot is excreted from the body through the intestines and kidneys, as well as through the sweat glands.
6. The active component of the medicine is distinguished by the peculiarity of penetration through the blood-brain and hematoplacental barriers. The macroelement magnesium is also found in breast milk.

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Dosing and administration

Method of administration and dosage.

Long-term use of the drug Magnerot is indicated in the following situations:

When symptoms of magnesium deficiency appear, which are caused by the presence of the following diseases and painful conditions in the human body:

• gastrointestinal diseases,
• systematic consumption of foods low in magnesium,
• systematic consumption of alcoholic beverages (symptoms of chronic alcoholism), which reduces the reabsorption of magnesium in the renal tubules and increases the excretion of magnesium from the body.

When taking the following types of medications that can reduce the amount of magnesium in the human body:

• oral contraceptives,
• diuretics,
• muscle relaxants,
• glucocorticoids,
• insulin.

For conditions that cause an increase in the body's need for magnesium:

• hypodynamia (disruption of the proper functioning of the body's systems caused by low physical activity, as well as a decrease in the strength of muscle contractions caused by the same reason),
• constant and severe stress,
• the period of pregnancy in women.

The method of application of Magnerot is as follows:

• It is prescribed to take two tablets of the medication three times a day,
• the course of treatment is one week,
• then the dosage of Magnerot is changed to one tablet two to three times a day,
• the modified course of treatment with Magne-Rot is carried out for at least four to six weeks,
• If necessary, therapy with Magnerot can be repeated.

For cramps that occur at night, the medication is taken in the evening, two to three tablets.

The maximum daily dose of Magnerot is up to six tablets.

The medicine should be taken one hour before meals. The tablets are washed down with a small amount of water, for example, one glass.

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Use Magnerot during pregnancy

The use of the drug Magnerot during pregnancy is as follows:

1. During pregnancy and lactation, specialists recommend taking magnesium preparations, including Magnerot.
2. Taking magnesium supplements is recommended for pregnant women and nursing mothers due to the significant increase in the female body's need for magnesium.
3. If there is not enough of this element in the mother and child's bodies, there is a high probability of unexpected and serious complications in the development of the baby and the health of the woman. Also, a lack of magnesium in the body of a pregnant woman can lead to spontaneous abortion.

Contraindications

Contraindications to the use of the drug Magnerot are as follows:

1. Existing hypersensitivity to the components of Magnerot.
2. Manifestation of symptoms of lactase deficiency and galactosemia, glucose-galactose malabsorption syndrome.
3. The use of the medication is contraindicated for those patients who exhibit manifestations of hypermagnesemia and hypocalcemia.
4. It is prohibited to use the drug to treat patients with signs of urolithiasis, liver cirrhosis with ascites and impaired renal function.
5. The use of Magnerot is also contraindicated in cases of atrioventricular block of I-II degree, as well as bradycardia.
6. The medication is not used to treat magnesium deficiency conditions, as well as diseases caused by this metabolic disorder, for the treatment of pediatric patients (under 14 years of age).
7. Patients taking the medication should be extremely careful when operating life-threatening machinery (this also applies to driving vehicles and cars).

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Side effects Magnerot

Taking the drug Magnerot can cause the following side effects in the human body:

1. Diarrhea may occur.
2. Signs of irregular bowel movements may also occur.
3. By reducing the amount of medication taken per day, the disturbing symptoms disappear.
4. Allergic reactions may occur in the form of skin rashes, redness of the skin, itching and burning of the affected areas.

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Overdose

• An overdose of the drug Magnerot causes an increase in the side effects that were described above in the previous section.
• If the renal function of the patient taking Magnerot is normal, then the appearance of signs of overdose is not observed or is observed in rare cases.
• Magnesium intoxication of the body is characterized by symptoms of central nervous system dysfunction. These include signs of nausea, vomiting, bladder obstruction, constipation, and respiratory paralysis.
• Magnesium intoxication can also manifest itself in the symptoms of cardinal health disorders: deterioration of the heart in the form of decreased atrioventricular conduction, as well as the appearance of excitation impulses from the ventricles. The effect of large amounts of magnesium on neuromuscular conduction in the form of a curare-like effect can also be observed.
• Magnesium intoxication is neutralized by intravenous administration of calcium (from one hundred to two hundred milligrams of Ca2+). Additional means include hemodialysis (a method of extrarenal blood purification), peritoneal dialysis (a method of intracorporeal blood purification), and artificial respiration.

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Interactions with other drugs

The interactions of the drug Magnerot with other drugs are as follows:

• If Magnerot is taken with drugs containing iron, this leads to difficulty in the absorption of the active substances contained in these drugs.
• The simultaneous use of Magnerot and tetracycline gives a similar result - a slowdown in the absorption of the active substances of the drug.
• The absorption of the active components of the sodium fluoride preparation is slowed down by Magnerot if these medications are taken simultaneously.
• Due to the above-mentioned features of Magnerot, this medication should be taken separately from iron preparations, tetracycline and sodium fluoride. The optimal interval between taking these medications is two to three hours.
• The drug Magnerot, when combined during administration, is capable of stimulating the effectiveness of drugs that have a depressing effect on the central nervous system. These drugs include sedatives, tranquilizers and neuroleptics.
• Antihypertensive and antiarrhythmic drugs begin to act with an enhanced effect when combined with Magnerot.
• Taking the medication Magnerot can reduce the risk of occurrence and progression of negative effects on the body, namely a decrease in the amount of magnesium, which can occur when taking certain medications. These include diuretics, aminoglycosides, cyclosporine, cisplatin, methotrexate, amfortericin and drugs with a laxative effect.

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Storage conditions

Storage conditions for the drug Magnerot are as follows:

1. Magnerot is contained in the original packaging.
2. The drug should be stored at room temperature from 15 to 25 degrees Celsius.
3. The medicine should be kept out of the reach of children.
   

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Shelf life

The shelf life of the medicine Magnerot is five years from the date of manufacture. It is prohibited to use the drug for treatment after the expiration date.

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