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Longitude is a medicine with proteolytic properties.





V03AX Прочие лекарственные препараты

Indications of longitude

Candles are shown in the complex treatment of pathologies that develop hyperplasia in connective tissues. The medicine is administered in the following cases:

  • Urology - treatment of chronic forms of prostatitis, interstitial cystitis form, and in addition with ureteral stricture urethra, prostate adenomas (in the early stages of the disease), as well as the Peyronie's disease;
  • gynecology - occurrence of adhesions in the pelvic area, accompanied by inflammatory processes in the inner genital organs (including disease - endometritis in the chronic stage, Asherman's syndrome, as well as infertility tuboperitoneal type);
  • surgery - to eliminate the scars hypertrophic type (among those obtained due to trauma, burns, operations, and pyoderma), adhesions, in the developing area due to operations of the peritoneum, and in addition, long-healing wounds;
  • dermatovenereology and cosmetology - elimination formed scarring or hypertrophic keloid type developing after surgical operations, injuries, and burns or pyoderma, and furthermore for the treatment of a limited form of scleroderma;
  • tuberculosis and pulmonology - pulmonary fibrosis, or infiltrative cavernous-fibrous form of tuberculosis, pulmonary tuberculoma, fibrosing alveolitis type, and besides siderosis with pulmonary fibrosis and interstitial pneumonia, and pleurisy form;
  • Orthopedics - Treatment of restricted mobility of joints, bruises, ankylosing spondylitis, and arthritis.

Furthermore, the candle may be used to increase the bioavailability parameters of antimicrobial drugs, as well as local anesthetics in pneumology, urology, and gynecology and dermatology.

According to a doctor's appointment Longidaza can be used for the prevention of scarring or strictures after surgery.


Longidase is a complex of macromolecules entering into the proteolytic enzyme of hyaluronidase and having a high molecular weight carrier. The carrier is an element from the category of N-hydroxy-poly-1,4-ethylene piperazine derivatives. Longidazu is distinguished by the powerful activity of hyaluronidase (it is several times higher than the activity of native-type hyaluronidase), which develops because the conjugate is more resistant to the effects of slowing components, as well as temperatures.

The drug has powerful anti-inflammatory, immunostimulating, anti-edema, antioxidant, and also chelating properties. Hyaluronidase contains specific substrates, which are glycosaminoglycans - the elements of connective tissues, among which chondroitin-4-sulfate, as well as chondroitin-6-sulfate, and in addition hyaluronan with chondroitin. The glycolysis process makes it possible to reduce the viscosity of glycosaminoglycans and, at the same time, the ability to synthesize metal ions with water. As a result, tissue trophism and permeability increase, resorption with hematomas and a reduction in the swelling, and in addition, the elasticity of the areas on which the scars are located improves. The glycolysis of these elements also allows to reduce the severity or completely remove the limited joint mobility and adhesions.

The most effective medicine will be in case of its use at the initial stages of treatment of the disease.

The antioxidant property of Longidase is ensured by the ability of the active ingredient to synthesize iron ions. These substances activate the response of free radicals, and in addition stimulate the processes of collagen binding and slowing down of hyaluronidase.

The pronounced antifibrotic effect of the drug is proved by a multitude of biochemical, electron microscopic, and histological tests performed on a sample of pneumofibrosis.

Candles normalize the process of synthesis of inflammation conductors, promote the strengthening of humoral immunity, and at the same time reduce the intensity of manifestations of inflammation during the acute stage of the disease.

The drug can be used to prevent the development of adhesions or scars after surgery, because it does not have a negative effect on the course of the postoperative period and does not provoke the progression of the infection. In addition, it does not interfere with the restorative process inside bone tissues.

Through the use of drugs, the level of bioavailability of other drugs increases, and with it the development of the effect of the use of local anesthetics is accelerated.

Longidase has a weak toxicity, the active substance of the drug does not affect the functioning of the immune and reproductive systems. It has no mutagenic, carcinogenic, and teratogenic properties.


After rectal administration, the active substance of the drug is rapidly absorbed into the systemic blood stream, after which it reaches its maximum values within 1 hour. After rectal or vaginal administration, the bioavailability of the substance is 70%.

The active component is able to pass through the BBB, the placenta, and also the ophthalmologic barrier. The carrier that is inside the body disintegrates, taking the form of oligomers, excreted through the kidneys in 2 phases.

The half-life of the substance after vaginal or rectal administration is 42-84 hours.

Use of longitude during pregnancy

It is forbidden to appoint Longidazu to women during lactation, and also to pregnant women.

If you can not refuse the use of lactation, you need to cancel breastfeeding for the period of treatment.


Among the contraindications of drugs:

  • It is forbidden in case of patient intolerance of the constituent elements of the medicine;
  • Do not use in the treatment of people with severe renal function disorders or malignant tumors;
  • is not assigned to children less than 12 years of age.

Caution is prescribed for people with kidney failure, and also for those who have recently had bleeding. In addition, caution is required if the patient has an infectious process in acute form (in this situation, the suppositories can be administered exclusively in combination with antimicrobial drugs).

Side effects of longitude

Due to the application of medicine can singly develop side reactions such as local or systemic manifestations of allergy.

Dosing and administration

Candles with medicine should be administered vaginally (from lying down before bedtime) or rectally (only after bowel movement). The size of the dose, as well as the duration of the course of therapy, are prescribed by the treating doctor.

For the treatment of urological pathologies, it is required to administer 1 st suppository rectally 1 time in 48 hours. After 10 introduced suppositories, the interval between applications should be increased to 2-3 days. In general, 20 candles are required for the course.

When eliminating gynecological diseases vaginally or rectally, 1 candle is administered once for 3 days. The general course of therapy includes 10 suppositories. If there is a need, after the main course, the appointment of maintenance treatment is possible.

For the treatment of dermatovenereological diseases, it is necessary to inject a 1-candle rectally every 2-3 days. In general, the entire course includes 10-15 candles.

To eliminate surgical disorders, rectal administration of the first candle is administered once with an interval of 2-4 days. In general, the course usually consists of 10 candles.

In the process of treatment of phthisiatric and pulmonological diseases, the rectal administration of the first candle is given once with intervals of 3-5 days. The general course includes the introduction of 10-20 candles of the drug.

Prescribe a repeat therapeutic course usually can be at least 3 months after the end of the previous one. Supportive treatment includes the introduction of the first candle once with intervals of 5-7 days during 3-4 months.

For people who have recently experienced bleeding, as well as those suffering from a chronic form of kidney failure, the recommended dosage is no more than 1 candle once per 7 days.

Interactions with other drugs

The drug enhances the properties of diuretics and antimicrobial drugs, as well as local anesthetic drugs when combined with them.

In the case of simultaneous use with estrogens, salicylates, corticotropin, as well as antihistamine drugs (all in high doses), the properties of Longidase are weakened.

It is forbidden to combine the drug with phenytoin, furosemide, as well as benzodiazepines.

Storage conditions

Storage of suppositories should be carried out at temperature values within the limits of 8-15 o C. The conditions for the place of detention of medicinal products are standard.

Shelf life

Longidaza candles can be used within 2 years since the release of the drug.

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To simplify the perception of information, this instruction for use of the drug "Longitude" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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