Lendacin

Lendacin is an antibacterial drug with high systemic activity. It belongs to the category of 3rd generation cephalosporin drugs. The specified drug is administered parenterally.

The drug has powerful bactericidal properties, exerting a therapeutic effect on a certain number of bacteria (gram-positive and -negative). Its active component is the element ceftriaxone, which demonstrates noticeable resistance to the activity of β-lactamases.

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Indications Lendacina

It is used for various diseases, the development of which is associated with the activity of strains of certain microbes:

• infectious and inflammatory infections affecting the respiratory system;
• pathologies of an otolaryngological nature;
• sepsis;
• cardiac disorders - endocardial disorder of infectious and inflammatory origin;
• established meningococcal infection;
• Gastroenterological problems – various diseases associated with the functioning of the gastrointestinal tract and having an infectious genesis;
• uro- or nephrology, as well as gynecology;
• infections associated with joint and bone tissue;
• lesions of the epidermis and subcutaneous layers (also arising from a disruption of their integrity – trauma or wound);
• feverish condition of typhoid nature, as well as shigellosis or salmonellosis caused by invasions;
• Lyme disease;
• diagnosed neutropenic fever associated with malignant tumors.

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Release form

The component is released in the form of a lyophilisate for the production of injection liquid. The box contains 1, 5 or 10 vials with the lyophilisate.

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Pharmacodynamics

Lendacin demonstrates bactericidal activity against the following pathogenic microorganisms:

• pneumococci, epidermal or golden staphylococci, viridans streptococci, gonococci with Haemophilus influenzae, meningococci, Ducray bacilli, pale treponemas and peptostreptococci, as well as Borrelia burgdorferi, serratia marcescens, plague bacilli, vulgaris Proteus and Proteus mirabilis;
• salmonella, citrobacter, enterobacter with coli, klebsiella with morgan bacteria, shigella and providencia (has no effect on strains that help produce β-lactamases).

It does not have therapeutic efficacy in diseases caused by the activity of Campylobacter jejuni, Clostridium difficile, Acinetobacter with Bacteroides fragilis, Listeria monocytogenes, Pseudomonas aeruginosa, faecal enterococci and staphylococci that are resistant to methicillin.

Chlamydia, mycoplasma and Koch's bacillus are resistant to the action of Lendacin.

The medication will be effective against bacterial strains that are resistant to other drugs from the specified group.

Pharmacokinetics

The drug demonstrates intensive absorption after intramuscular injection. Cmax values in plasma occur quite quickly. The bioavailability level is 100%.

The Vd values of the drug are quite high; the drug quickly enters into tissue fluids.

In the case of treating meningococcal infections in pediatrics (from birth), 17% of the drug penetrates into the cerebrospinal fluid. In adults with the same disease, after 2-24 hours from the moment of administration of 50 mg/kg of weight, the level of the drug in the cerebrospinal fluid exceeds the MIC values.

The drug is excreted mainly through the kidneys (approximately 55%), and also through the intestines (approximately 45%). The average half-life of the drug is approximately 8 hours.

This half-life helps maintain plasma and tissue values of the drug (approximately 24 hours), which exceed the tissue and plasma MIC levels of some pathogenic bacteria sensitive to Lendacin. Due to this, only 1 injection of the drug per day can be administered.

It is necessary to take into account the difference in the pharmacokinetics of drugs in young children (under 8 days) and the elderly - the average half-life is 16 hours.

In addition, changes in the excretion of the drug in newborns are observed - the rate of excretion in urine increases to 70%.

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Dosing and administration

The medication is administered parenterally - through intramuscular injections or intravenous infusions (at low speed, at least half an hour).

Persons over 12 years of age are required to take 1-2 g of the medication 1 time or 2 times (with a 12-hour interval) per day. Thus, per day, with 2-time infusion of the medication, no more than 4 g of the medication is administered.

For people over 18 years of age, 0.25 g is administered intramuscularly for gonorrhea, once a day. No more than 0.25 g of the substance can be used per day.

Children under 12 years of age are given 50-75 mg/kg of the drug once or twice (with a 12-hour break) per day. A child may be given no more than 2 g of Lendacin per day.

For persons under 12 years of age, when treating meningococci, 0.1 g/kg is administered once or twice (12-hour interval) per day. A maximum of 4 g of the substance is allowed per day. The duration of the treatment course ranges from 7 to 14 days.

Newborns are given 20-50 mg/kg of the drug by infusion at a slow rate. The number of procedures per day and the maximum permissible daily dose are selected individually.

In severe stages of liver or kidney disorders, it is necessary to change the standard dosage regimen of the drug. Half of the standard dose should be administered, and in addition, plasma values of the drug should be monitored during therapy.

Scheme of liquid production and its subsequent use.

Intramuscular injections.

The liquid for such procedures is prepared using solvents that have an anesthetic effect (to reduce the pain that occurs during the injection). When preparing the medicine, 1 g of lyophilisate is diluted in 1% lidocaine (3.5 ml; 0.25 g per 2 ml).

The injection is made deep into the gluteal muscle. It is forbidden to use more than 1 g for 1 buttock. To minimize the risk of local signs of allergy, injections are made in turn into each buttock.

Liquids prepared with lidocaine cannot be used for intravenous procedures.

Intravenous injections.

The solvent is injection water at a rate of 1 g of medication per 10 ml of liquid (0.25 g/5 ml).

It should be administered at low speed – over 2-4 minutes.

Intravenous infusions.

For 2 g of powder, use 40 ml of solvent - calcium-free infusion fluid (0.45%/0.9% NaCl, 5% levulose, 2.5%/5%/10% dextrose or 6% dextran with dextrose).

The infusion is carried out at a low speed – for at least half an hour.

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Use Lendacina during pregnancy

The decision regarding the use of drugs during pregnancy should be made by the attending physician, taking into account the balance of benefits for the woman and the likelihood of negative consequences for the fetus.

You cannot breastfeed your child during bactericidal treatment with Lendacin, because its active ingredient is excreted in breast milk. If you need to use the drug, you must stop breastfeeding for the duration of therapy.

Contraindications

Contraindicated for use in case of diagnosed intolerance to medications of the specified category.

It is prescribed with extreme caution in the following situations:

• severe sensitivity associated with penicillins (because there is a high probability of intensification of allergic symptoms);
• presence of hepato- or nephropathologies;
• gastrointestinal disorders;
• history of diseases associated with the gallbladder.

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Side effects Lendacina

Side effects include:

• problems with digestion and the gastrointestinal tract: vomiting, stomatitis, flatulence, nausea, loose stools, and in addition hyperbilirubinemia, increased activity of intrahepatic enzymes and pseudomembranous colitis;
• damage to the hematopoietic function: a decrease in the number of eosinophils with leukocytes, an increase in the rate of thrombus formation, hemolytic anemia and a decrease or increase in the number of platelets in the blood;
• urinary dysfunction: decreased urine output or increased blood creatinine levels;
• CNS related disorders: dizziness or headaches;
• local signs: development of phlebitis or pain and discomfort during the administration of the drug and after the injection;
• manifestations of allergy: epidermal rashes and itching, hyperthermia, dermatitis, Quincke's edema, erythematous rashes accompanied by the appearance of exudate, as well as urticaria and anaphylactoid symptoms (decreased blood pressure and bronchial spasm).

Overdose

In case of an overdose of the drug, vomiting, nausea, or loose and frequent stools may occur, as well as convulsions or disturbances of consciousness.

If the above symptoms occur, consult a medical professional. Take appropriate symptomatic measures. Lendacin has no antidote. Hemodialysis will be ineffective.

Interactions with other drugs

Combination with cyclosporine causes an increase in its plasma values, as a result of which its toxicity also increases.

Use together with antiplatelet agents or NSAIDs significantly increases the likelihood of bleeding.

The combination with diclofenac leads to a change in the excretion of the drug - renal excretion is weakened with a concomitant increase in intestinal excretion along with bile.

Use in combination with acetazolamide results in hyperconcentration of the drug within the gastric contents.

Lendacin must not be administered or mixed with antibacterial agents (antibiotics from other pharmacological categories).

Infusion fluids containing the element Ca must not be mixed with the medication.

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Storage conditions

Lendacin must be stored in a dark and dry place at a temperature not exceeding 25°C.

Shelf life

Lendacin can be used within a 3-year period from the date of manufacture of the drug. The finished liquid has a shelf life of 6 hours if stored at 25°C, and 24 hours if kept in a refrigerator (2-8°C).

Application for children

Should not be used in newborn infants who have been diagnosed with elevated bilirubin levels.

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Analogues

Analogues of the drug are Azaran, Movigip, Torotsef, Axone with Longacef, and also Betasporin, Rocephin, Medaxon with Biotriaxone and Sterycef with Megion. In addition, the list includes Ificef, Cefatrin, Lifaxon and Tornaxon, Cefogram and Oframax, Ceftriabol with Tercef, Hizon and Triaxone with Cefson, as well as Forcef, Ceftriaxone and Cefaxone.