Lendacin

Lendacin is an antibacterial drug with high systemic activity. He is in the category of cephalosporins of the 3rd generation. The specified means is introduced by the parenteral method.

The drug has powerful bactericidal properties, providing a therapeutic effect on a certain number of bacteria (gram-positive, as well as negative). Its active component is the element ceftriaxone, which shows a marked resistance regarding the activity of β-lactamase.

[1], [2]

Indications Lendacina

It is used in a variety of diseases, the development of which is associated with the activity of strains of certain microbes:

• infections of infectious and inflammatory nature affecting the respiratory system;
• pathologies of otolaryngological nature;
• sepsis ;
• cardiac disorders - an inflammatory-inflammatory endocardial disorder;
• established meningococcal infection;
• gastroenterological problems - various diseases associated with the work of the gastrointestinal tract and having infectious genesis;
• uro- or nephrology, as well as gynecology;
• infections associated with joint and bone tissue;
• lesions of the epidermis and subcutaneous layers (also arising from the integrity of their integrity - injury or injury);
• feverish typhoid nature, as well as shigellosis or salmonellosis, provoked by invasions;
• Lyme disease;
• diagnosed neutropenic fever associated with malignant tumors.

[3]

Release form

The release component is in the form of a lyophilisate for the manufacture of injection fluid. Inside the box contains 1, 5 or 10 bottles with lyophilisate.

[4]

Pharmacodynamics

Lendacin demonstrates a bactericidal effect on the following pathogens:

• pneumococci, epidermal or Staphylococcus aureus, Streptococcus viridans, gonococci with Haemophilus influenzae, meningococci, Dyukreya sticks, and peptostreptokokki pale treponema, borrelia and addition Burgdorfera, martsestsens Serratia, Yersinia pestis, Proteus vulgaris, and Proteus mirabilis;
• salmonella, citrobacter, enterobacter with intestinal bacilli, Klebsiella with morgan bacteria, shigella and providence (no effect on strains that help the production of β-lactamase).

It has no therapeutic efficacy in diseases caused by the activity of Campunobacter jejuni, clostridium differential, acinetobacteria with frateris bacteroids, Listeria monocytogenes, Pseudomonas bacilli, fecal enterococci and staphylococci that are resistant to methicillin.

Resistance to the action of Lendacin exhibit chlamydia, mycoplasma and Koch sticks.

The drug will be effective against bacterial strains that are resistant to other drugs from the specified group.

Pharmacokinetics

The drug shows intense absorption after intramuscular injection. Indicators Cmax inside the plasma when this occurs fairly quickly. The level of bioavailability is 100%.

Vd values of the drug are quite high; The drug quickly enters the interior of fluids with tissues.

In the case of treatment of infections associated with meningococci in pediatrics (since birth), 17% of the drug penetrates the CSF. In adults with the same disease after 2-24 hours from the moment of application of 50 mg / kg of weight, the level of drugs inside the cerebrospinal fluid exceeds the values of BMD.

The elimination of drugs is implemented mainly through the kidneys (approximately 55%), and in addition to the intestines (approximately 45%). The average term for the half-life of a drug is about 8 hours.

Such a half-life term helps to preserve the plasma and tissue values of the drug (approximately 24 hours), which exceed the tissue and plasma levels of BMD in some disease-causing bacteria that are sensitive to Lendacin. Thanks to this, only one injection of the drug can be performed per day.

It is necessary to take into account the difference in the pharmacokinetics of drugs in young children (less than 8 days) and the elderly - the average half-life term is 16 hours.

In addition, there are changes in the removal of medication in newborns - the rate of excretion in the urine increases to 70%.

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Dosing and administration

The drug is injected parenterally - through intramuscular injections or intravenous infusions (at low speed, at least half an hour).

Persons older than 12 years of age are required to use 1-2 g of the drug 1-fold or 2-fold (with a 12-hour interval) per day. Thus, in a day, with a 2-time infusion of medication, no more than 4 g of medication is administered.

For people over the age of 18, for gonorrhea, 0.25 g intramuscularly is used, once a day. A day can use no more than 0.25 g of the substance.

For children under the age of 12 years, 50-75 mg / kg of drugs are used once or twice a day (with a 12-hour break) per day. For the day, the child can enter no more than 2 g of Lendacin.

In the treatment of meningococci, patients under 12 years of age are administered 1 time or 2 times (12-hour interval) per day at 0.1 g / kg. A maximum of 4 g of a substance is allowed per day. The duration of the treatment course varies from 7-14 days.

Newborn infants, at a slow rate, apply 20-50 mg / kg of the drug. The number of procedures per day and the maximum allowable portion per day is selected personally.

In severe stages of liver or kidney disorders, it is required to change the standard dosage regimen of the drug. It is necessary to introduce half of the standard portion, and in addition to monitor the plasma values of the drug during therapy.

The scheme of manufacture of the fluid and its subsequent use.

Intramuscular injections.

Fluid for such procedures is made using solvents that have an analgesic effect (to reduce the pain that occurs when the injection is given). In the manufacture of drugs 1 g of lyophilisate diluted in 1% lidocaine (3.5 ml; 0.25 g per 2 ml).

The injection is made deep inside the gluteus muscle. It is forbidden to use more than 1 g for the 1st buttock. To minimize the risk of local signs of allergy, injections are made in turn in each buttock.

Liquid produced with lidocaine cannot be used for IV procedures.

Intravenous injections.

The solvent is injected water with a calculation of 1 g of the drug per 10 ml of liquid (0.25 g / 5 ml).

It should be entered at low speed - for 2-4 minutes.

Intravenous infusions.

For 2 g of powder, 40 ml of solvent is used - non-calcium infusion liquid (0.45% / 0.9% NaCl, 5% levulose, 2.5% / 5% / 10% dextrose, or 6% dextran with dextrose).

Infusion is carried out at low speed - for at least half an hour.

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Use Lendacina during pregnancy

The decision on the use of drugs during pregnancy should be made by the attending doctor, taking into account the ratio of benefits for the woman and the probability of negative consequences for the fetus.

It is impossible to breastfeed a child during the bactericidal treatment using Lendacin, because its active element is excreted from the mother's milk. With the need to use the medication, it is necessary to refuse breastfeeding during therapy.

Contraindications

It is contraindicated to use in case of diagnosed intolerance in relation to drugs of the specified category.

With extreme caution prescribed in such situations:

• strong sensitivity associated with penicillins (because there is a high probability of intensifying the signs of allergy);
• the presence of hepatologic or nephropathology;
• disorders of the gastrointestinal tract;
• history of diseases associated with the gallbladder.

[6]

Side effects Lendacina

Among the side effects are:

• problems with the work of digestion and gastrointestinal tract: vomiting, stomatitis, flatulence, nausea, diarrhea, and in addition hyperbilirubinemia, increased activity of intrahepatic enzymes and colitis of the pseudomembranous variety;
• damage to the hematopoietic function: a decrease in the number of eosinophils with leukocytes, an increase in the rate of blood clot formation, anemia of the hemolytic form and a decrease or increase in the number of platelets inside the blood;
• urinary disorders: decrease in urine output or increase in blood creatinine values;
• disorders associated with the central nervous system: dizziness or headaches;
• local signs: the development of phlebitis or pain and discomfort during the introduction of drugs and after the completion of the injection;
• manifestations of allergy: epidermal rash and itching, hyperthermia, dermatitis, angioedema, erythematous rash, accompanied by the appearance of exudate, as well as urticaria and anaphylactoid symptoms (decrease in blood pressure and bronchial spasm).

Overdose

In case of overdose with medication, vomiting, nausea or loose and frequent stools may occur, and in addition to this, convulsions or disorders of consciousness.

After the occurrence of the above manifestations should consult a medical professional. Corresponding symptomatic actions are performed. Lendacin has no antidote. Hemodialysis will be ineffective.

Interactions with other drugs

The combination with cyclosporine causes an increase in its plasma values, as a result of which its toxicity is enhanced.

Use together with antiplatelet agents or NSAIDs significantly increases the likelihood of bleeding.

The combination with diclofenac leads to a change in the elimination of the drug - renal excretion is weakened with a concomitant increase in intestinal excretion along with bile.

Use in combination with acetazolamide leads to hyperconcentration of the drug inside the gastric contents.

Do not enter or mix Lendacin with antibacterial agents (antibiotics from other pharmacological categories).

Infusion fluids containing the element Ca are not allowed to be mixed with medication.

[8], [9], [10]

Storage conditions

Lendacin is required to be stored in a dark and dry place, at a temperature not exceeding 25 ° C.

Shelf life

Lendacin can be used within a 3-year term from the date of manufacture of the drug. The finished liquid has a shelf life of 6 hours in the case of storage at 25 ° C, as well as 24 hours in the case of refrigeration (2-8 ° C).

Application for children

Do not use newborn babies who have been diagnosed with an increased rate of bilirubin.

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Analogs

Analogues of the medication are the medicines Hazaran, Movigip, Torotsef, Axon with Longacef, and besides Betasporin, Rotsefin, Medaxone with Biotriaxone and Stericef with Megion. In addition, Ifitsef, Cefatrin, Lifaxon and Thornakson, Cefograf and Oframax, Ceftriabol with Tercef, Hison and Triaxone with Cefson, and Forcef, Ceftriaxone and Cefaxone are on the list.