Lazoleks

Lazolex (internationally known as Ambroxol) is a solution for injections that is used to treat newborns and premature babies if they develop a respiratory distress syndrome.

What is this syndrome? Usually it arises from the disturbance of the breathing of infants and is formed during intrauterine development (in the prenatal and neonatal stages). Most often, a distress syndrome occurs in premature babies that are born between 28 and 36 weeks of pregnancy. Timely treatment using rational methods makes it possible to minimize the risk of death. Among the main symptoms of the development of distress syndrome of newborns can be noted the following: dyspnea, pale skin, rigidity (increased resistance) of the chest and cyanosis (cyanosis of the skin). Respiratory disorders in the form of distress syndrome may not appear immediately, but after some time after birth.

Lazoleks is used as a mucolytic agent that acts on the respiratory system and has antitussive and expectorant properties.

Indications Lazoleks

Lazolex is used exclusively for the treatment of premature and newborn children with breathing problems (distress syndrome of the lungs). This drug is widely used in modern medical practice and has pronounced mucolytic properties. In 1 ml of the solution for injection contains 7.5 mg of the active substance - ambroxol hydrochloride.

Indications for use Lazoleks: treatment of respiratory distress syndrome in newborns and premature babies.

The main property of the drug is an increase in the secretion of mucus, as well as increased synthesis of lung surfactant and stimulation of ciliary activity. This effect contributes to the unhindered separation of mucus that accumulates in the airways, and its rapid excretion.

In addition, Lazolex has a number of other properties:

• has a pronounced anti-edematous effect;
• has anti-inflammatory effect;
• reduces hypoxemia (reduction of oxygen in the blood);
• increases natural protection of the lungs;
• strengthens local immunity;
• Suppresses the process of exacerbation of chronic bronchitis;
• helps increase the concentration of antibacterial drug in the bronchial mucosa, thereby facilitating the course of the disease in pulmonary bacterial infections.

Release form

Lazoleks as a mucolytic drug is a solution for injections. In appearance it is a colorless or slightly yellow liquid of a transparent consistency.

The form of the drug - ampoules, containing 2 ml of medicine in a package of 5 pcs. Each milliliter contains 7.5 mg of the main active substance - ambroxol hydrochloride. In the role of auxiliary components are citric acid monohydrate (E 330), sodium chloride, sodium dodecahydrate phosphate (E 339), and water for injection.

The parenteral (injectable) route of administration of Lazolex can achieve several important goals: to ensure the speed of the drug, the accuracy of dosage, and also to avoid the influence of digestive enzymes on the drug and exclude the barrier function of the liver. In addition, the introduction of a drug with the help of infusion is indispensable in the provision of emergency care. This is especially true in cases of treatment of pulmonary distress syndrome in newborns and premature babies for whom injections of lazolex become one of the ways to get rid of respiratory pathology and accelerate the process of recovery. It should be noted that the diagnosis and treatment of respiratory distress syndrome of premature infants is strictly in the conditions of the maternity home.

Pharmacodynamics

Lasolex contains the basic substance ambroksol, whose action is aimed at increasing the secretion of mucus in the airways, as well as enhancing the synthesis of pulmonary surfactant - a surface-active substance that regulates the tension of the pulmonary alveoli when their volume changes. In addition, ambroxol promotes stimulation of ciliary (motor) activity. As a result of this action, the mucus secretion process is improved and its active removal from the respiratory tract is carried out. Thus, the mucociliary clearance, which is a nonspecific mechanism aimed at local protection of mucous respiratory organs from infection and various external influences, is increased. This is the pharmacodynamics of Lazolex. By activating fluid secretion and increasing mucociliary clearance, the mucus removal process is facilitated, cough is reduced. As a result of medical studies in vitro, it was possible to prove that the effect of the drug Lazolex led to a decrease in the number of cytokinins (phytohormones), polymorphonuclear cells and mononuclear cells. Effective action of the drug allows to achieve the desired results in the treatment of premature infants, who have a syndrome of lung distress.

Pharmacokinetics

Lazoleks is used to treat respiratory pathology in premature babies who need urgent medical attention due to respiratory failure almost immediately after birth.

Pharmacokinetics Lazoleks is that ambroxol - the main active substance of the drug - binds to plasma proteins (in infants - by 60-70%, in adult patients - by 90%). The drug has the property of penetrating the placenta into the fetal lungs. Ambroxol accumulates in the tissues, as indicated by the high volume of its distribution, from 6 to 7 l / kg. According to the results of the research, the metabolism of ambroxol first of all occurs in the liver, after which it disintegrates, except for some metabolites, which are almost completely (up to 90%) excreted together with urine. It has been established that the half-life of the preparation from the blood plasma is approximately 9-10 hours. Also with the help of medical research it is proved that after the repeated introduction of Lazolex to newborns, the half-life period is approximately combined due to the reduced clearance.

Treatment of preterm infants with lazolex should be carried out in the conditions of a medical institution, i.e. In the hospital, under the strict supervision of qualified doctors.

Dosing and administration

The instructions for the drug Lazoleks indicate the method of administration and the dose of the drug. The drug is applied 4 times a day with the calculation of dosage of 30 mg per 1 kg of the child's weight. When you inject the solution, you must follow certain rules, in particular, inject it through the infusomat very slowly, for 5 minutes. "Infuzomat" is a special device, which is a kind of pump designed for dosed administration of drugs and solutions during intensive care.

The solution of lazolex can be used as a drop infusion. In this case, the drug is combined with a solution of glucose (5%), sodium chloride (0.9%), levulose (5%), or with Ringer's solution (multicomponent physiological solution). That the process of introduction of Lazolex was carried out correctly, it is necessary to take into account the rules of working with the ampoule. First, it is necessary to separate the ampoule from the overall package and, while holding it by the neck, gently shake it. Then you should gently squeeze the ampoule with the medicine by hand and separate the head with rotational movements. In the resulting hole you need to insert a syringe, then turn the ampoule and slowly, slowly, draw all the contents into the syringe.

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Use Lazoleks during pregnancy

Lazoleks in solution for injections is intended only for the treatment of newborns who have respiratory pathologies. Many people are interested in the question "Using Lasolex during pregnancy". In this regard, it should be noted that separately Ambroxol is used by pregnant women after the 28th week. At the same time, as a result of preclinical studies and clinical experience, no harmful effects from this drug were identified. At the same time, it is necessary to remember the responsibility in the use of medicines during the bearing of the child, especially in the first months after conception, when there is a high risk of miscarriage and the development of intrauterine pathologies. Ambroxol has the property of penetrating into breast milk, but there is no evidence of its effect on fetal health when taken in therapeutic doses.

With regard to the diagnosis of "respiratory distress", for its approval, the data of the clinical picture, in particular, the study of thromboplasty activity and the composition of amniotic fluid, are necessary. Most often, RDS is diagnosed in premature infants who were born before the 34th week, as well as children whose mothers have diabetes. Among other factors provoking the development of RDS, we can note the multiplicity, isoserological incompatibility of blood of the mother and fetus, bleeding due to detachment and presentation of the placenta, asphyxia, morphofunctional immaturity of the fetus due to hereditary or congenital pathology.

Contraindications

Lazolex is used in cases of development in newborns, and most often - premature babies, respiratory pathology, which is usually found in the neonatal period. The main causes of this problem lie in acquired or congenital diseases of the respiratory tract. In addition, respiratory distress syndrome can result from parenchyma of the lungs, intrauterine pathologies and various malformations of the lungs, brain or heart, asphyxia or anemia, metabolic disorders, and other factors that can cause a hypoxia of the tissues or acute respiratory failure in the child.

In the instructions to the drug in the section "Contraindications to the use of Lasolex" it is noted that the only contraindication is the increased sensitivity of the organism to the active substance - ambroxol, or the auxiliary components of this drug. Treatment with Lazolex is carried out under the supervision of doctors directly in the maternity hospital.

It should be noted that the development of respiratory failure in newborns is a consequence of a deficit of surfactant and is observed directly at the birth of premature babies or after a few hours after childbirth.

Side effects Lazoleks

Lazolex can have some side effects, and this must be taken into account when carrying out therapy in newborns.

Side effects of Lazolex can be manifested by nausea, mild manifestations of heartburn, dyspepsia, vomiting and diarrhea (on the part of the digestive organs), as well as rashes on the skin and urticaria. There were cases of angioedema, anaphylactic reactions (including anaphylactic shock) and other allergic manifestations.

In extreme cases, when taking Lazoleks, severe skin lesions are possible, in particular, the development of Stevens-Johnson syndrome (toxic-allergic disease) or Lyell's syndrome-epidermal toxic necrolysis. Such severe cases of side effects of Lazolex can be explained by taking in the treatment of concomitant medications and an extremely serious condition of the patient, i.e. The severity of the course of the underlying disease.

If the mucous membrane or skin is damaged, the treatment regimen should be reviewed urgently. Naturally, you should stop taking Lazoleks.

Overdose

Lazoleks is injected into the newborn in a hospital setting, so treatment is carried out with strict adherence to all rules and regulations, according to the scheme prescribed by the attending physician.

An overdose of the drug did not occur. It should be noted that, regardless of the form of release of a drug, in case of an overdose, symptomatic treatment is usually performed. Related activities are aimed at prompt removal of the medicine from the patient's body. In particular, the introduction of water-salt solutions, forced diuresis (detoxification method), as well as hemodialysis (extrarenal blood purification).

To avoid an overdose with Lazolex, you need to follow the dosage set by your doctor. The action of any drug is determined by its dose, and a violation of the dosing rules provokes the development of symptoms of an overdose. When taking medication, you need to consider all factors: the characteristics of the patient's body, age, weight, sensitivity to the active substance of the drug, etc. As a result of a long overdose of the drug, chronic poisoning of the organism is observed, in which the medicine acts as a poison, disrupting the work of internal organs and tissues and damaging them.

Interactions with other drugs

Lazoleks is prescribed in the form of injections or infusions for the treatment of respiratory pathologies in newborns. Most often, the drug is used to restore the respiratory functions of premature babies, who have difficulty with a deficit of pulmonary surfactant almost immediately after they are born.

The interactions of Lazolex with other drugs have some peculiarities. Thus, with the simultaneous use of the drug Lazoleks with ambroxol, there is an increase in the concentration of antibiotics in the sputum and bronchopulmonary secretions, such as erythromycin, amoxicillin, cefuroxime. About any unwanted interactions of Lazolex with medicines to date, there is no accurate information. The drug is injected into the newborn strictly in a hospital (maternity hospital), so it is provided with the correct dosage taking into account the body weight of the child, as well as complex treatment according to the scheme established by a qualified doctor. This also applies to other drugs that, in combination with Lazolex, give the desired therapeutic result - first of all, this is getting rid of the problems associated with respiratory dysfunctions.

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Storage conditions

Lazolex is a modern drug from the mucolytics group, which is widely used by neonatologists for the treatment of premature infants, as well as newborns who need urgent help in the fight against respiratory pathologies, in particular, distress syndrome.

Lazoleks, like any solution intended for injection, should be stored in the original (factory) packaging under a temperature regime that does not exceed 25 ° C. The solution should not be frozen and heated. The instructions to the drug also indicate that an important storage condition is a place not accessible to children.

The storage conditions of Lazolex are similar to those of other sterile drugs in ampoules. Usually the storage period of such drugs reaches several years, but always pay attention to the expiration dates. Thanks to hermetic sealing of ampoules, the drug is protected from exposure to oxygen, as well as microflora. It is inadmissible to leave drugs in a sunny place, because the composition of the drug under the influence of high temperatures is able to change. This must be taken into account when storing medicines.

Shelf life

The instructions to Lazolex clearly indicate the expiration date of this drug - 2 years. It should be borne in mind that after opening the ampoule, the medicine should not be stored. The unused solution should be disposed of immediately, since the sterility is broken when the ampoule is opened.

An obstacle to the use of a solution for injections is a change in its color, turbidity, and also the appearance of a precipitate. Before using any medication, it is necessary to read the instructions - the recommendations from the manufacturer clearly indicate the storage conditions and the shelf life of the medication. Usually such information is available on the package to the medicine.