Jenodex

Genoide is a complex medicine of SCS, which has an antimicrobial effect.

Indications Gennadox

It is used for the treatment of eye pathologies:

• blepharitis, which is allergic or infectious;
• anterior uveitis, conjunctivitis or keratitis;
• ulcers in the cornea that are bacterial;
• barley, scleritis or dacryocystitis;
• eye lesions caused by chlamydia;
• irit, ethylchloride or iridocyclite;
• sympathetic form of uveitis;
• neuritis affecting the optic nerve;
• inflammation, developed as a result of trauma in the eye area;
• prevention of complications of infectious nature after surgical procedures, as well as interventions to eliminate foreign objects.

It is also used in the treatment of ear diseases:

• otitis of external character;
• a localized form of the neurodermite;
• dermatitis having a seborrheic character;
• eczema ;
• prevention of complications of infectious genesis after surgical procedures.

Release form

Release of the medicine is done in drops for the ears or eyes. The medicine is contained in glass bottles with a capacity of 5 ml; In a pack - 1 such flakonchik, equipped with a dropper.

Pharmacodynamics

Genoide has an anti-inflammatory effect, which is provided by the activity of dexamethasone, as well as the antibacterial effect caused by the action of antibiotics such as polymyxin B and chloramphenicol.

Polymyxin B is a polypeptide antibiotic whose effect is based on the ability to synthesize with phospholipids inside the bacterial cell walls and, in addition, destroy the function of the enzymes of the respiratory chain of sensitive microbes and the ion permeability of the walls, which leads to the loss of potassium ions by bacterial cells.

Demonstrates activity against a variety of gram-negative microbes. Has a bactericidal effect against the dysentery, as well as E. Coli, Pseudomonas aeruginosa, typhoid bacillus, and parathyphus rods.

Chloramphenicol has a wide range of therapeutic effects. The antimicrobial effect develops by slowing down the processes of protein binding within the ribosomes of sensitive microbes. Has a bacteriostatic effect, and when used in large doses - bactericidal.

The element affects both gram-negative and-positive microbes, and in addition to rickettsia with mycoplasmas, as well as chlamydia. In addition, it affects the activity of bacterial strains resistant to streptomycin, penicillin and sulfonamides. Resistance to chloramphenicol is expressed by fungi and Pseudomonas aeruginosa. In some types of microbes, moderate resistance slowly manifests itself, which only in single cases is cross.

Dexamethasone is an artificial SCS with anti-inflammatory, immunosuppressive and anti-allergic properties. The substance stabilizes the walls of leucocytic lysosomes.

The component helps to bind and release lipomodulin, inhibiting the activity of phospholipase A2, slows down the formation of arachidonic acid degradation products, reduces the number of lymphocytes transported to the site of inflammation with monocytes, and also prevents the release of inflammatory mediators from the labocytes and eosinophils. At the same time, it strengthens capillary strength and reduces exudation, normalizes the release of cytokines (IL-1 and IL-2, as well as γ-interferon from monocytes with lymphocytes) and induces an involution in the lymphatic tissue. Suppress the activity of proteases and hyaluronidase.

Dexamethasone interacts with specific protein ends of target tissues, promotes the regulation of expression of conforming genes, and affects protein binding.

The substance stimulates the processes of protein catabolism and induces the activity of enzymes responsible for the metabolic processes of amino acids. The drug weakens the binding, enhances protein breakdown inside the tissues of lymph, musculature, connective tissue and epidermis. In addition, it helps restore the sensitivity of adrenoreceptors to catecholamines.

Pharmacokinetics

Polymyxin B is not absorbed through the mucous membranes and epidermis, but can be absorbed in the case of local administration of the substance into the eye, when there are tissue damage.

After topical use of chloramphenicol at high speed passes through the cornea (even if there is no inflammation). High solubility indices inside lipids with water allow quickly reaching the required medicinal values inside the tissue eye fluid.

GCS is absorbed through the iris, cornea, eye fluid, retina with the choroid and ciliate epithelium. Injected into the conjunctival sac dexamethasone without complications passes inside the conjunctiva and corneal epithelium. Drug concentrations are noted inside the aqueous eye. If the eye tissue is inflamed or corneal / mucosal damage is noted, the rate of absorption of the element is significantly increased. When using drops in the required medicinal portions, systemic influence does not develop.

The duration of the anti-inflammatory effect of the drug upon instillation of a 0.1% drop in the eye of the 1st drop is 4-8 hours. Approximately 60-70% of dexamethasone entering the circulatory system is synthesized with the blood plasma protein. Metabolism of this element occurs inside the liver with the participation of hemoprotein enzymes СUR2С; excretion of metabolic products mainly occurs with feces. The half-life usually lasts 3 hours.

Dosing and administration

Genoidex demonstrates a higher efficacy in case of its use in the treatment of acute forms of pathologies, rather than chronic ones.

During eye pathologies, 1-2 drops of medication should be instilled inside the conjunctival sac hourly throughout the day, and then at night, at intervals of 2 hours, at the initial stage of therapy. If the drug has a positive effect, the dosage is reduced to the 1st drop at intervals between procedures of 4 hours. Then the dose is reduced to the 1st drop 3-4 times a day - this scheme should be optimally suited for monitoring the patient's condition.

Therapy for ear diseases: first you need to carefully clean the area of the external auditory canal. First it is required to dig in 3-4 drops of medicine 2-3 times a day. After obtaining the desired result, the dosage is gradually reduced, reaching the cancellation of the drug. The duration of such therapy may vary depending on the type of disorder and the drug's drug effectiveness; it should be selected by the doctor, separately for each patient (minimum - several days, maximum - several weeks).

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Use Gennadox during pregnancy

You can not prescribe a medication breastfeeding mothers or pregnant women.

Contraindications

The main contraindications:

• tuberculosis in the ears or the eye, which is infectious in nature;
• common herpes;
• chickenpox;
• early stage of herpes simplex in acute form;
• diseases in the eyelid and conjunctiva that have a purulent or viral character;
• pathologies affecting the cornea, and accompanied by epithelial defects;
• trachoma or glaucoma;
• the assumption of an infection having a fungal origin;
• rupture of the tympanic membrane;
• the presence of intolerance relative to the elements of the drug.

Side effects Gennadox

The use of drops can cause some side-effects:

• increase in IOP indicators;
• Glaucoma, against which there is damage, affecting the optic nerve;
• weakening of visual acuity and narrowing of the visual field;
• photosensitivity;
• appearance of a subcapsular form of cataract of the back type;
• eye-related infection, secondary in nature, caused by the activity of pathogenic pathogens, among which simple herpes, isolated from the eye tissues;
• rupture in the eyeball area.

If there is a thinning of the cornea, there is a possibility of its rupture. With prolonged use of drops, cataracts appear.

Occasionally, the appearance of a filtering type pemphigus was recorded - with the local application of steroids after an operation to remove cataracts. Also, the use of steroids can exacerbate the corneal infectious processes of fungal or viral origin. Sometimes there is a feeling of burning or tingling.

When the substance is instilled in the ear, itching may occur, as well as, sometimes, ear noise or dizziness.

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Interactions with other drugs

It is forbidden to combine Zhenodex with streptomycin or monomycin, because this can lead to potentiation of ototoxicity.

You can not combine the drug with erythromycin, because it is an antagonist of the chloramphenicol component.

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Storage conditions

The jenodex should be kept in a dark and dry place, closed from penetration of children. The temperature is not more than 25 ° C.

Shelf life

Genoidex is allowed to be used within 18 months of the release of the therapeutic agent. Shelf life of the solution from the already opened bottle is 30 days.

Application for children

Jenodex is not used in the treatment of children younger than 3 years of age.

Analogues

Analogues of the drug are drugs Garazon, Pledrex, Dexa with Sofradeksom and Combinil duo.