Jes

Jess is a monophasic contraceptive for oral use. It has antimineralocorticoid and antiandrogenic properties.

Indications Jesa

It is used as a contraceptive to prevent pregnancy. It can also be used to treat moderate acne and to eliminate severe symptoms of PMS.

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Release form

The substance is released in tablets, 28 pieces per blister pack.

Jazz Plus

Jess Plus is sold in tablets - 24 active, as well as 4 auxiliary ones inside a blister pack. Inside the pack - 1 such package.

Pharmacodynamics

The contraceptive suppresses the ovulation process and at the same time affects cervical secretions, as a result of which the free penetration of sperm through them is prevented.

Women who use this drug say that its use stabilizes the menstrual cycle, reduces the amount of bleeding and pain during menstruation. As a result, the likelihood of developing anemia decreases. The use of complex oral contraceptives also reduces the risk of endometrial and ovarian carcinoma.

The active component of the drug drospirenone has an antimineralocorticoid effect. Its effect prevents the accumulation of excess weight and the occurrence of edema. In addition, it has a positive effect on the condition during PMS, reducing pain in the joints and chest, psychoemotional disorders and other negative manifestations.

This element also demonstrates antiandrogenic activity, thereby positively affecting the condition of the epidermis. As a result, the severity of acne and the degree of oiliness of hair and skin are reduced. The effect of drospirenone is similar to the effect of natural human progesterone.

Drospirenone does not have androgenic, estrogenic, anti- and glucocorticoid effects. In combination with ethinyl estradiol, this component has a positive effect on the lipid profile.

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Pharmacokinetics

When taken orally, drospirenone is absorbed almost completely and at a high rate. Peak values are recorded after 1-2 hours after use. The bioavailability values of the drug are within 76-85%; however, they are not tied to the time of food intake. With course use, the serum Cmax level of drospirenone is observed within 7-14 days of therapy.

The metabolic processes of orally administered drospirenone are extensive. Only a small portion of the element is excreted unchanged. The decay products are excreted through the intestines and kidneys. The drug is well tolerated by people with mild to moderate liver failure.

Ethinylestradiol taken orally is absorbed completely and at a high rate. With a single dose, peak values are recorded after 1-2 hours. The bioavailability level is approximately 60%. Metabolism occurs through aromatic hydroxylation processes. Excretion of metabolic products occurs with urine and bile.

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Dosing and administration

When using the contraceptive drug Jess, it is necessary to strictly follow the instructions for its use. It is necessary to take the tablets exclusively in the order described on the package. The medicine is taken daily, at about the same time, with a small amount of any liquid. The size of the daily portion is 1 tablet, which is taken over a period of 4 weeks. A new pack should be started the next day after using the last tablet from the previous pack. Bleeding often begins on the 2-3 day after the drug is discontinued.

Women who have not used any hormonal contraceptives during the previous month should start using Jess on the first day of the new menstrual cycle. You can also start taking it on the 2nd-5th day, but in such a situation it is recommended to additionally use barrier contraceptives (during the first week of using the drug).

The scheme for using the tablets in case of switching to the drug from other methods of contraception should be clarified with the gynecologist who recommended the drug.

After an early abortion, the medication can be used immediately; additional contraceptive methods do not need to be used.

If an abortion is performed in the 2nd trimester (or if the birth occurred during this period), it is recommended to start using the drug on the 21st-28th day after the incident.

If you miss an inactive pill, you can ignore it. However, at the same time, such a pill should be thrown away without using it.

If you miss an active tablet (with a delay of no more than 12 hours), the contraceptive effect is not weakened; the medicine should be taken as quickly as possible. If the delay lasts more than 12 hours, 2 tablets were missed, or the break was even longer, the effectiveness of protection is significantly reduced. Thus, in accordance with the increase in the duration of the interval between doses, the risk of conception also increases.

Based on the above, we can conclude that skipping medications can lead to the following consequences: with an interval of 4+ days, the risk of fertilization increases significantly. For adequate suppression of the activity of the hypothalamic-pituitary system of the ovaries, it is necessary to take the medicine without interruption for a period of 7 days.

Therefore, if a tablet was missed, it should be taken as quickly as possible (it is allowed to take 2 tablets at a time). Then the use of active tablets continues in the standard mode. Inactive ones are thrown away, starting a new pack of drugs. In such cases, the probability of bleeding is quite low, but slight discharge may still occur.

If, when there is a break in the use of active tablets during a cycle of taking the tablets, bleeding does not begin during the period of using inactive tablets, it is necessary to exclude the possibility of conception.

If the patient has severe gastrointestinal disorders, the absorption of the active element of the drug may be incomplete. In this case, it is recommended to use additional contraceptives. If vomiting occurs within 4 hours of taking the medicine, you must take the actions prescribed for missing a dose.

Regarding the discontinuation of Jess and the transition to other methods of contraception, you should consult with your gynecologist.

Use Jesa during pregnancy

It is prohibited to use Jess during lactation or pregnancy. If pregnancy is detected during the use of the drug, its use should be discontinued.

The tests conducted confirmed that pregnancies that occur after discontinuing the use of the drug occur without the development of negative reactions in the child.

Because oral contraception can have a negative impact on the volume and composition of breast milk, Jess should not be used until breastfeeding has been stopped.

Contraindications

Main contraindications:

• thrombosis of an arterial or venous nature, as well as thromboembolism (current or in history) and cerebrovascular disorders;
• conditions observed before the development of thrombosis;
• presence of migraine now or in the anamnesis;
• diabetes mellitus, against the background of which vascular manifestations are observed;
• the presence of risk factors for the development of thrombosis in a woman, either venous or arterial;
• pancreatitis accompanied by hypertriglyceridemia (both current and history);
• liver failure and liver pathologies of severe severity;
• neoplasms in the liver area that are malignant in nature (current or in history);
• severe renal failure in the acute stage;
• malignant diseases caused by hormones (or suspicion of their presence);
• adrenal insufficiency;
• vaginal bleeding of unknown origin;
• suspicion of pregnancy;
• the presence of intolerance to the components of the drug.

Caution is needed when using the drug in people with any factors that can cause thrombosis, thromboembolism and other pathologies, against the background of which a peripheral circulatory disorder may occur. It should also be used with caution in any liver disease, hypertriglyceridemia and Quincke's edema, which is hereditary.

The medication should be used with caution by women during the postpartum period, and also by those who have developed or worsened diseases during pregnancy or the use of sex hormones, including cholestasis with herpes, otosclerosis, cholelithiasis with porphyria, etc.

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Side effects Jesa

Most often, the use of drugs causes the following negative symptoms:

• development of nausea;
• irregular menstruation;
• having genital bleeding of unknown origin;
• pain in the mammary glands.

Rarely, serious manifestations such as thromboembolism (venous or arterial) are observed.

Sometimes the following side effects occur:

• migraine;
• lability or depression of mood, as well as a decrease in libido;
• erythema multiforme.

In addition, some other disorders develop sporadically, which can be caused by the use of Jess:

• neoplasms;
• increased blood pressure;
• erythema nodosum;
• increased signs of Quincke's edema;
• liver dysfunction;
• impact on the body's resistance to insulin, as well as impaired glucose tolerance;
• regional enteritis;
• chloasma;
• ulcerative form of colitis, which has a non-specific form;
• manifestations of hypersensitivity.

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Overdose

There are no reports of severe poisoning with the drug. In case of overdose, the patient may develop nausea, metrorrhagia and vomiting, and spotting may also occur.

Symptomatic measures are used to eliminate disorders.

Interactions with other drugs

Combined use of the drug with other drugs (including drugs that induce enzyme activity and some antibiotics) may cause breakthrough bleeding and reduce the reliability of the contraceptive.

The combination of Jess with substances that induce microsomal liver enzymes (such as primidone with rifampicin, barbiturates, phenytoin with carbamazepine, etc.) leads to an increase in the level of clearance of sex hormones.

Exposure to certain antibiotics may reduce estrogenic circulation within the liver and intestine, resulting in decreased levels of ethinyl estradiol.

When combined with medications that affect microsomal enzymes, and in addition, within 28 days from the moment of discontinuing these drugs, additional contraception must be used. During the first week, additional contraceptives should be used after using tetracyclines or ampicillins.

The drug is capable of influencing the metabolic processes of other drugs.

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Storage conditions

Jess should be kept in a place protected from moisture and small children. Temperature values should not exceed 30°C.

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Shelf life

Jess can be used within 5 years from the date of manufacture of the drug.

Application for children

Teenage girls can use the medicine from the moment their first menstruation begins.

Jess can also be prescribed to teenagers to treat acne. In this case, it is considered to be highly effective.

Analogues

Analogues of the drug are Yarina, Midiana, as well as Jess Plus and Dimia.

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Reviews

Jess receives a large number of reviews on Internet forums. Often, women who took this drug were satisfied with it, although there are also comments from those who had negative reactions to the drug, including a feeling of malaise, nausea, headaches, etc. When such symptoms appeared, patients tried to find a more suitable medication for themselves.

Doctors also leave positive reviews regarding the effectiveness of the drug, as well as its positive impact on the female body. Among the comments, there are reports that thanks to the drug, acne was eliminated, as well as the condition of the epidermis was improved. Discontinuation of the drug does not lead to a deterioration in health, so many patients comment positively on the drug.