Jess

Jess is a single-phase oral contraceptive. It has antimineralocorticoid and antiandrogenic properties.

Indications Jessa

It is used as a contraceptive preventing pregnancy. In addition, it can be used for therapy with moderate-type acne and to eliminate severe signs of PMS.

[1],

Release form

Release of the substance is made in tablets, 28 pieces each inside the blister plate.

Jazz plus

Jess plus is realized in tablets - 24 active, and also 4 auxiliary ones inside the blister pack. Inside the pack - 1 such a package.

Pharmacodynamics

The contraceptive inhibits the process of ovulation, and at the same time it affects the cervical secretions, as a result of which the free penetration of spermatozoa through them is prevented.

Women who use this drug, say that his method stabilizes the menstrual cycle, reduces the profuse bleeding and pain during menstruation. As a result, the probability of anemia is reduced. The use of complex oral contraceptives weakens the risk of carcinoma of the endometrium and ovaries.

The active component of the drug drospirenone has an antimineralocorticoid effect. Its effect prevents the accumulation of excess weight and the appearance of edemas. In addition, it positively affects the condition of PMS, easing pain in the area of the joints and chest, psychoemotional disorders and other negative manifestations.

This element also demonstrates antiandrogenic activity, thereby positively affecting the condition of the epidermis. As a result, the acne and the fat content of the hair with the skin decrease. The effect of drospirenone is similar to that of natural human progesterone.

Drospirenone does not possess an androgenic, estrogenic, and anti-and glucocorticoid effect. In combination with ethinyl estradiol, this component positively affects the lipid profile.

[2], [3], [4], [5], [6], [7],

Pharmacokinetics

When ingested, drospirenone is absorbed almost completely and at high speed. Peak indicators are recorded after 1-2 hours after use. Values of bioavailability of drugs - within 76-85%; while they are not tied to the time of eating. At the course of the application, the serum level of Cmax of drospirenone is observed within 7-14 days of therapy.

The metabolic processes of orally administered drospirenone are extensive. Only a small part of the element is excreted unchanged. Decay products are excreted through the intestine with the kidneys. The medicine is well tolerated by people with liver failure of mild or moderate nature.

Efficant ethinyl estradiol is absorbed completely and at high speed. With a one-time admission, peak values are recorded after 1-2 hours. The bioavailability level is approximately 60%. Metabolism occurs during aromatic hydroxylation processes. Excretion of metabolic products is carried out with urine and bile.

[8], [9], [10], [11], [12], [13], [14],

Dosing and administration

When using the Jas contraceptive, it is necessary to follow the instructions for its use exactly. It is required to use tablets exclusively in the order that is described on the package. The medicine is consumed every day, at about the same time, with a small amount of a liquid at a time. The size of the daily portion - 1 tablet, which is taken in the period of 4 weeks. A new pack should be started the next day after using the last tablet from the previous pack. Bleeding often begins on the 2-3 day after the abolition of drugs.

Women who did not use any hormonal contraceptive drugs during the previous month, begin using Jess in the first day of the new menstrual cycle. It is also possible to start the procedure from the 2nd-5th day, but in this situation it is recommended to additionally use barrier contraceptives (during the first week of drug use).

The scheme of using tablets in case of switching to a drug from other methods of contraception should be clarified by a gynecologist who recommended a medicine.

After an early abortion, you can start using the medication immediately; you do not need to use additional contraceptive means.

When performing an abortion in the 2nd trimester (or if the birth occurred during this period), it is recommended to start the drug on the 21-28th day after the incident.

If you skip an inactive tablet, you can not give this value. But at the same time, this tablet must be discarded without using.

When the active tablet is passed (with delay not more than 12 hours), there is no attenuation of the contraceptive effect; The drug should be taken as quickly as possible. If the delay period is longer than 12 hours, 2 tablets were missed, or the break was even longer, the effectiveness of protection is significantly reduced. Thus, in accordance with the increase in the duration of the interval between applications, the risk of conception also increases.

Based on the above, it can be concluded that admission admission can lead to such consequences: at an interval of 4+ days, the risk of fertilization is significantly increased. To adequately suppress the activity of the hypothalamic-pituitary ovary system, it is required to use the medicine without interruption for 7 days.

Therefore, if the tablet has been omitted, it should be used as quickly as possible (two tablets are simultaneously allowed). The use of active tablets is then continued in standard mode. Inactive when this is thrown, starting a new pack of drugs. In such cases, the probability of bleeding is rather low, but weak allocation can still occur.

If, after the interruption of the use of active tablets during the intake cycle, bleeding has not started during the use of inactive tablets, the probability of conception should be excluded.

If the patient has strong abnormalities in the work of the digestive tract, the absorption of the active element of the drug may be incomplete. In this case it is recommended to use additional contraceptives. If vomiting occurs within 4 hours after taking the medication, you need to take the actions prescribed when you miss the appointment.

Concerning the termination of the use of Jess and the transition to other methods of contraception, one should consult his gynecologist.

Use Jessa during pregnancy

Use Jess in lactation or pregnancy is prohibited. If pregnancy is detected during the use of drugs, its reception should be canceled.

The tests that have been carried out confirmed that pregnancies that occur after withdrawal of the drug use occur without the development of negative reactions in the child.

Because oral contraception can have a negative effect on the volume and composition of the mother's milk, you can not use Jess until you stop breastfeeding.

Contraindications

The main contraindications:

• thrombosis, which is of an arterial or venous nature, as well as thromboembolism (now or in anamnesis) and cerebrovascular disorders;
• the conditions observed before the development of thrombosis;
• the presence of migraine now or in history;
• Diabetes mellitus, against which vascular manifestations are noted;
• presence of risk factors for a woman with a venous or arterial thrombosis;
• pancreatitis accompanied by hypertriglyceridemia (both now and in the anamnesis);
• Liver insufficiency and hepatic pathology, which have a severe degree of severity;
• neoplasms in the liver that have a malignant character (whether present or in history);
• severe degree of kidney failure in the acute stage;
• The hormone-induced diseases of a malignant nature (or a suspicion of their presence);
• insufficiency of the adrenal function;
• having an unknown nature of bleeding from the vagina;
• suspected pregnancy;
• the presence of intolerance with respect to the components of the drug.

Caution is needed when using medicines in people with any factors that can cause thrombosis, thromboembolism, and other pathologies against which a circulatory disorder of the peripheral type may occur. It should also be used with caution in any hepatic disease, hypertriglyceridemia and edema Quincke, which is hereditary in nature.

Caution should be used in women during the postpartum period, and in addition to those who have developed or worsened during pregnancy or use of sex hormones, including cholestasis with herpes, otosclerosis, cholelithiasis with porphyria and so on.

[15], [16], [17]

Side effects Jessa

Most often, the use of drugs causes such negative symptoms:

• development of nausea;
• irregular menstruation;
• having an unknown genesis of bleeding from the genitals;
• pain in the mammary glands.

Occasionally, such serious manifestations as thromboembolism (having a venous or arterial form) are noted.

Sometimes there are such side effects:

• migraine;
• lability or depression of mood, and also weakening of libido;
• polyforma of erythema.

In addition to this, some more irregularities develop, which can be caused precisely by the use of Jess:

• neoplasms;
• increased blood pressure;
• erythema nodosum form;
• increased signs of edema Quincke;
• disorders of hepatic activity;
• impact on the body's resistance to insulin, as well as impaired glucose tolerance;
• regional enteritis;
• chloasma;
• Ulcerative form of colitis, having a non-specific form;
• manifestations of hypersensitivity.

[18], [19]

Overdose

There is no information about severe drug poisoning. In case of an overdose, the patient may develop nausea, metrorrhagia and vomiting, and may also have an excretory discharge.

Symptomatic measures are used to eliminate the disorders.

Interactions with other drugs

Combined use of the drug with other drugs (among them, drugs that induce enzyme activity and some antibiotics) can cause breakthrough bleeding and reduce the level of contraceptive reliability.

The combination of Jess with substances that induce microsomal hepatic enzymes (such as primidone with rifampicin, barbiturates, phenytoin with carbamazepine, etc.) leads to an increase in the level of clearance of sex hormones.

Exposure to certain antibiotics may decrease estrogenic circulation within the liver with the intestines, resulting in a decrease in the level of ethinyl estradiol.

When combined with medicines that affect microsomal enzymes, and in addition, within 28 days after the withdrawal of these funds, additional contraception is required. During the first week, additional contraceptives should be used after using tetracyclines or ampicillins.

The drug is able to influence the exchange of other drugs.

[20], [21]

Storage conditions

Jess is required to be kept in a place that is closed from penetration of moisture and small children. The temperature is not above 30 ° C.

[22]

Shelf life

Jess is allowed to be used within 5 years from the date of manufacture of the drug.

Application for children

Girls in adolescence can use the medicine from the moment of onset of the first menstruation.

Also, Jess can be prescribed to adolescents for the treatment of acne. It is believed that in this case it has a high efficiency.

Analogues

The analogues of the medication are preparations of Yarin, Midian, and also Jess Plus and Dimia.

[23], [24]

Reviews

Jess receives a large number of reviews on Internet forums. Often, women who took this remedy were happy with it, although there are also comments from those who received negative reactions, including a feeling of malaise, nausea, headaches, and so on. At occurrence of such signs of the patient tried to pick up for itself more suitable medicine.

Doctors also leave positive feedback on the effectiveness of the drug, as well as its positive effects on the female body. Among the comments there are reports that thanks to the medicine it was possible to eliminate acne, as well as improve the condition of the epidermis. Removing the drug does not lead to a deterioration in health, so many patients positively comment on the drug.