Jasnal

Yasnal is a medication that selectively inhibits the acetylcholinesterase of the brain. As a rule, it is used to treat patients with dementia. We bring to your attention the instruction on the medical use of the drug Yasnal.

Indications Jasnal

The drug is used to relieve and relieve symptoms in Type I Alzheimer's disease (senile dementia of the Alzheimer's type) - the primary degenerative dementia of elderly presenile and senile patients, uncomplicated and medium variant of the disease course.

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Release form

Jasnal is a tablet with an external protective coating (film). The active ingredient is donepezil hydrochloride.

The tablets are packed in blister packs and cardboard boxes, No. 7, No. 10, No. 28, No. 56, No. 60, No. 98 or No. 120.

[2]

Pharmacodynamics

Acetylcholinesterase is the dominant cholinesterase type in the brain. The active ingredient Yasnal is able to inhibit this substance a thousand times more than pseudocholinesterase, which is found, as a rule, outside the central nervous system.

After a single use of Yasnal in an amount of 5 to 10 mg, the activity of acetylcholinesterase decreases from 63 to 77%.

This drug is able to inhibit the further development of dementia, smooth out some cognitive impairments, often - to stimulate the activity of patients during the day, which greatly simplifies the possibility of caring for them. The course of treatment Yasnal helps to eliminate behavioral disorders, improves mood, eliminates hallucinatory disorders and unconscious motor acts.

[3], [4], [5], [6]

Pharmacokinetics

After oral administration of the drug, the limiting level of the active substance in the plasma can be observed after 3-4 hours. The amount of donepezil in plasma is the higher, the larger the dose of the drug taken. Half-life from the plasma can last up to 70 hours, so the equilibrium concentration of the drug is observed for 14-21 days from the start of treatment.

Eating does not affect the absorption of the active ingredient of the drug.

The connection with plasma proteins is 95%. Experts believe that the active substance together with metabolites can be in the body for 10 days or more.

Metabolism of the drug occurs in the liver, excretion - through the urinary system, or to a lesser extent - with bile.

After a single use of the drug in an amount of 5 mg, the level of the unchanged active substance in the blood serum can be 30% of the dosage used.

In patients with a slight or slight disorder of the hepatic function, plasma concentrations may increase.

[7], [8], [9], [10],

Dosing and administration

Adult patients receive the drug at an initial dosage of 5 mg per day, at a time. Such treatment of the patient should take from 1 to one and a half months, to establish a stable level of the drug in the blood and determine the effectiveness of the drug. Further, at the discretion of the doctor, the dosage can be increased to 10 mg per day: this amount of the drug is considered the maximum daily dosage.

The course of therapy can last long enough if the doctor sees a positive dynamics from taking Yasnal.

[15], [16], [17], [18], [19], [20]

Use Jasnal during pregnancy

Special and confirmed studies regarding the use of Yasnal during pregnancy and breastfeeding were not conducted. Information on the penetration of the active component of the drug into breast milk at the moment does not exist.

If this is possible, then it is better to avoid using Yasnal during pregnancy and feeding.

Contraindications

• Pregnancy and breastfeeding.
• Children under 18 years of age (no clinical data available).
• Propensity to allergic reaction to any of the constituents of the drug.

Carefully prescribe the drug to patients with obstructive process of the respiratory system, with asthmatic conditions, with arrhythmia, with ulcerative processes of the digestive tract or with a tendency to them.

[11], [12], [13], [14]

Side effects Jasnal

• Slowing of the heart rhythm, in some cases - sinoatrial and atrioventricular blockade.
• Fainting condition, fatigue, sleep disturbances, hallucinations, irritability and aggression, headache, in some cases, convulsions.
• Dyspeptic disorders, attacks of nausea and vomiting, less often - the development of ulcerative process in the digestive tract.
• Loss of control over the release of urine.
• Skin rashes, possibly accompanied by itching.
• Pain in muscles and joints, body aches, convulsive conditions.

Overdose

There is no information on cases of overdose with Yasnal. If you suspect an overdose, symptomatic therapy should be prescribed. There is no special antidote to the drug.

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Interactions with other drugs

Due to the lack of full information about the use of Yasnal, when prescribing the drug, it is necessary to assess the danger of the combined action of certain groups of drugs.

Metabolism of the active component of the drug occurs with the participation of the isoenzyme substance CYP3A4 and less often - CYP2D6. Thus, drugs that inhibit these isoenzymes can inhibit the metabolic processes of Jasnal. These medications include quinidine, erythromycin, fluoxetine and ketoconazole. The combined use of these drugs in conjunction with Yasnal can increase the level of donepezil in plasma by approximately 25-30%.

Caution should be given to the joint use of Yasnal with rifampicin, ethyl alcohol, carbamazepine and phenytoin, since such combinations may lower the level of the active ingredient Yasnal in the blood. The degree of lowering the level of the drug is unknown.

The active component of Jasnal enhances the effect of muscle relaxants, as well as drugs that affect cardiac conduction.

With the combined administration of Yasnal and other cholinomimetic and anticholinergic drugs, there may be fluctuations in blood pressure and heart rate.

[22], [23], [24]

Storage conditions

Medication Yasnal can be stored in a darkened place, at t ° no more than + 25 ° C. In no case is it allowed to allow children to store medicines.

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Shelf life

Shelf life - up to 36 months from the date of issue.