Isodibut

Isodibut is a medicament for diabetics. We will familiarize with his instruction: indications, side effects, dosage and the possibility of interaction with other means. Isodibut refers to the pharmacological group of hormones, their analogs and anti-hormonal drugs. It is included in the category of oral antidiabetic medications. Suppresses the activity of aldose reductase, that is, an enzyme that is involved in the transformation of intracellular glucose into sorbitol. The inhibitor stimulates the energy processes in the brain and inhibits the sorbitol glucose exchange pathway.

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Indications Isodibut

Izodibut is used to treat and prevent complications of diabetes mellitus.

The main indications for use:

• Diabetic cataract
• Diabetic angiography of lower extremities
• Nephropathy
• Retinopathy
• Polyneuropathy (somatic, cerebral, encephalopathy)

The active component of the drug stops the accumulation of sorbitol in the ophthalmic lens and nerves, preventing the development of ophthalmic diseases, disorders of the tone of the nervous and vascular system. Starts metabolic processes in the brain.

Release form

The medicine has a tabletted form of release, 10 tablets in a blister for 3, 5 blisters in a package. Its chemical name is 1,3-dioxo-1H-benzo [d, e] isoquinoline-2 (3H) butyric acid. According to its physico-chemical properties: tablets of white color with a flat surface and a yellowish tinge, have a round shape with a risk and a facet.

The composition of one tablet includes: 500 mg of isodibut, potato starch, sodium starch, lactose (200), calcium stearate and hydroxypropyl ethylcellulose (15).

Pharmacodynamics

According to pharmacodynamics data, the drug is included in the class of inhibitors of the aldose reductase enzyme. The active substance lowers the activity of aldose reductase in 1,5-3 times and increases the activity of sorbitol dehydrogenase by 1.2-1.4 times. This leads to oppression of the sorbitol glucose exchange pathway and stops its accumulation in vascular walls, nerves, and lenses. Such activity leads to inhibition of glycosylation of proteins.

• Reduces the number of glycosylated proteins in the blood and cell membranes.
• Prevents tissue damage: vessels, nerves, lens and stops their swelling.
• It improves metabolism and memory, speeds up metabolic processes and microcirculation of the brain.
• Improves blood flow to the retina and conjunctiva, increases visual acuity.
• Reduces albuminuria and improves renal blood flow.
• Promotes restoration of sensitivity, accelerates the healing of wound surfaces and relieves pain in the lower extremities.

Pharmacokinetics

After ingestion, the tablets are completely absorbed from the gastrointestinal tract. Pharmacokinetics indicates the maximum concentration in the blood in 3-3.5 hours. The half-life is 6-6,5 hours.

The drug is not cumulated in the body. To maintain a constant therapeutic concentration, three meals a day is necessary. Active components are excreted by the kidneys with urine.

Dosing and administration

It is recommended to take isodibut before meals 1 tablet 3 times a day. But for all patients the way of application and dose is chosen by the attending physician. The maximum permissible daily dose is 8 tablets. Duration of treatment 2-3 months with a second course after 6 months.

If the medicine is used to prevent complications of diabetes mellitus, the tablets are taken for 2 months 2 times a year. If the patient has gastrointestinal diseases, then the medicine should be taken after meals. Isodibut does not affect the concentration of attention and the ability to work with mechanisms.

Use Isodibut during pregnancy

Isodibut refers to antidiabetic agents. Its use during pregnancy is possible only with medical appointment, when the expected therapeutic benefit for the mother is higher than the potential risks to the fetus.

Contraindications

As any pharmacological agent, isodibut has a contraindication to the use of:

• Individual intolerance of active components
• The age of patients younger than 14 years
• Severe kidney disease
• Renal insufficiency

If these restrictions are not observed, uncontrolled adverse symptoms from many organs and systems may appear.

Side effects Isodibut

In most cases, the drug is well tolerated. Side effects occur when non-compliance with recommendations for its use. Possible skin allergic reactions: skin rash, hives, itching. These symptoms most often occur in patients with a polyvalent allergy.

To eliminate side effects, you must stop taking the drug and seek medical help.

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Overdose

If the dosage or the duration of the therapy prescribed by the doctor is exceeded, signs of an overdose appear. Most often, patients face such symptoms of hypoglycemia:

• Increased sweating
• Cardiopalmus
• General weakness and anxiety
• Pale skin
• Violation of coordination of movement
• Neurological disorders (violation of sensitivity, vision, speech, paralysis)
• Paresthesia in the mouth and shivering of the limbs
• Loss of consciousness

For treatment, gastric lavage is performed and a sugar solution or glucose inside is taken. In severe hypoglycemia with loss of consciousness, the patient is administered intravenously, intramuscularly or subcutaneously with a 40% glucose solution or glucagon. To restore normal health, the patient is given food rich in carbohydrates. This helps prevent the re-development of hypoglycemia.

Interactions with other drugs

For complex treatment, the interaction of isodibut with other drugs is possible. The drug potentiates the effect of such drugs:

• Insulin
• Angiotropic drugs
• Oral hypoglycemic drugs
• Hypotensive drugs
• Sulfur compounds (Sodium thiosulfate, Unitiol)
• A-lipoic acid

With the simultaneous use of several drugs, medical advice and permission is needed.

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Storage conditions

Tablets for storage should be kept in their original packaging, protected from moisture and sunlight. The recommended storage temperature should not exceed 25 ° C. Failure to comply with these recommendations leads to damage to the medicine and loss of its medicinal properties.

Shelf life

The isodibut can be used for 36 months from the date of production. At the end of the expiry date, the medication is disposed of and is not used for treatment. Antidiabetic remedy is released only on the prescription.