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Inspira
Last reviewed: 23.04.2024
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Inspra has a diuretic effect.
Indications Inspira
It is used for myocardial infarction - to reduce the frequency of sudden general and cardiac mortality. Also prescribed after the transfer of myocardial infarction in persons with insufficiency of the function of the left ventricle.
Used with standard therapy of CHF.
[1]
Release form
The release of the drug produced in tablets of 25 or 50 mg, in the amount of 30 pieces inside the pack.
Pharmacodynamics
The active element of the drug prevents the synthesis of progesterone and androgenic endings with aldosterone, which is involved in the regulation of blood pressure levels and the appearance of pathologies of the CVS function. When eplerenone is added to treatment in patients with CHF, an increase in aldosterone levels is predicted.
Using Inspra in people with acute myocardial infarction significantly reduces the likelihood of mortality in this category of disease.
The antihypertensive effect on average develops after a 14-day period, and after 1 month of regular use reaches maximum levels. The severity of the impact lasts for 8-24 weeks.
[2]
Pharmacokinetics
Absorption of eplerenone, as well as its distribution within the body, is carried out at high speed (the Cmax level is noted after 2 hours). Bioavailability is 69%. Eating does not affect the degree of absorption.
The intraplasma protein synthesis of eplerenone is 50%; binding to red blood cells is not observed.
Excretion by 67% occurs with urine, and another 32% with feces. The half-life is approximately 3-5 hours.
[3],
Dosing and administration
In the case of CHF or myocardial infarction, the therapy should be started with a portion of 25 mg and then increased to 50 mg over the course of the first month (controlling the blood values of potassium). Use medication should be 1-time per day.
The use of drugs does not depend on the use of food.
Use Inspira during pregnancy
Information on the use of the drug in pregnant women is not available. The data that were obtained after tests on animals do not demonstrate a mediated or direct negative effect on the course of pregnancy, fetal and postnatal development, as well as on the process of childbirth. Pregnant drug is prescribed with great caution.
There is no information as to whether eplerenone is excreted with breast milk when taken orally. At the same time, preclinical testing has shown that eplenon or its metabolic products are found inside the milk of rats, but this does not affect the development of their offspring. Because there is no information about the possibility of developing negative symptoms in infants, it is necessary to decide whether to cancel breastfeeding or taking the medication - taking into account its importance for the woman.
Side effects Inspira
Acceptance of Inspra can cause side effects:
- headaches, severe dizziness and fainting;
- eosinophilia or hyperkalemia;
- a decrease in blood pressure values, left ventricular function insufficiency, insomnia, atrial fibrillation, or myocardial infarction;
- pharyngitis or cough;
- nausea, bloating, diarrhea, cholecystitis, obstipation or vomiting;
- itching, hyperhidrosis and local manifestations of allergy;
- malaise and asthenia.
[6]
Overdose
No data on the development of an overdose of eplerenone. In theory, one should expect the appearance of hyperkalemia and a decrease in blood pressure indicators.
Interactions with other drugs
Eplerenone can not be combined with potassium drugs, because they potentiate the effect of antihypertensive drugs.
You can not combine eplerenone with lithium, because this increases the likelihood of poisoning the latter.
It is forbidden to take the medicine together with cyclosporine or tacrolimus, due to the fact that this increases the likelihood of hyperkalemia and disorders in the kidneys.
Tricyclics, neuroleptics, and amifostine with baclofen in combination with Inspray potentiate the hypotensive activity of the drug.
The combination of medication and GCS causes sodium retention and fluid inside the body.
When using the drug with trimethoprim, there is an increase in the likelihood of developing hyperkalemia.
[7]
Storage conditions
Inspra should be maintained at temperatures of at most 25 ° C.
Shelf life
Inspra can be used within a 2-year period from the time the drug is manufactured.
Application for children
Prohibited appointment in Pediatrics (up to 18 years of age).
Analogs
Analogues of the drug are means Decree, Spironolactone, Eplethorus with Renial, and also Veroshpiron and Espiro.
Reviews
Inspira receives good reviews from medical specialists - the drug is considered to be quite effective. In people with CHF or heart attack, there is a significant decrease in post- and preload relative to cardiac function, the development and progression of left ventricular hypertrophy is slowed down, blood pressure decreases, diastolic ventricular activity improves and there is a decrease in swelling and congestive signs in the area of soft tissues.
[8]
Attention!
To simplify the perception of information, this instruction for use of the drug "Inspira" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.