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Cholera vaccination
Last reviewed: 07.07.2025
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Cholera is endemic in many countries. Cholera vaccination is carried out when there is a risk of importation in border areas. Two cholera vaccines are used.
The bivalent chemical cholera vaccine in tablets is a mixture of choleragen-anatoxin obtained from formalin-inactivated broth culture of cholera vibrio 569B or 569 (KM-76) serovar Inaba, and O-antigens obtained from broth cultures of cholera vibrio 569B or 569 (KM-76) serovar Inaba and M-41 serovar Ogawa, by isolation, purification and concentration with ammonium sulfate. Tablet filler - sugar, starch, talc, calcium stearate. Tablet shell made of acetylphthalyl cellulose. Cholera vaccination is carried out from the age of 2 years. One vaccination dose consists of three tablets. Tablet - grayish-yellow mass, covered with a shiny acid-resistant shell, tasteless and odorless. Release form: in vials containing 210 tablets (70 human doses). The vaccine is stored in a dark place at a temperature of 0-10°. Shelf life is 3 years.
The dose of cholera vaccine tablets for vaccinating an adult is 3 tablets, for teenagers aged 11-17 years - 2 tablets, for children aged 2-10 years - 1 tablet. The tablets are taken orally 1 hour before meals, swallowing them whole, without chewing, with boiled water. This provides antibacterial, antitoxic and local intestinal immunity lasting up to 6 months. Revaccination is carried out 6-7 months after the primary vaccination.
[ Reaction to the introduction and contraindications to the cholera vaccination
The cholera vaccine in tablets does not cause a general (temperature) reaction. 1-2 hours after administration, unpleasant sensations and pain in the epigastric region, rumbling in 0.2% of cases, a single mushy stool may occur.
There are no special contraindications to vaccination against cholera with these vaccines.
Attention!
To simplify the perception of information, this instruction for use of the drug "Cholera vaccination" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.