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Last reviewed: 23.04.2024
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Indications Indapene
It is used in the treatment of people with various types of hypertension.
Release form
The release is realized in tablets, which are packed in blister packs of 10 pieces. Inside the box there are 2, 3 or 6 packs.
Indapen sr
Indapen sr is produced by 14 or 15 tablets inside the blister plate. The pack contains 2 or 4 plates.
Pharmacodynamics
The constituent element of Indapen is the substance indapamide, a diuretic of the thiazidopod type.
This element reduces the contractile activity of the vascular layer of smooth muscle by affecting the transmembrane process of ion exchange, and in addition, by stimulating the binding of PG E2.
Use of the drug leads to a gradual decrease in blood pressure. Indapamide has a more pronounced antihypertensive effect than a diuretic; at the same time, it should be noted that a decrease in blood pressure values is observed only in persons with AH.
Along with this, the drug can weaken left ventricular hypertrophy. The drug has no pronounced effect on the processes of glucose metabolism and lipid status.
Pharmacokinetics
After oral administration, the medicine is well absorbed, entering the intestine. Peak values within the blood plasma are noted after 1-2 hours after drug use.
About 75% of the drug element undergoes protein synthesis inside the plasma. The drug achieves equilibrium values by the 4th day of treatment.
Excretion of the active substance LS mainly proceeds through the kidneys, in the form of inactive metabolic products, and about 20-30% is excreted through the intestine. The half-life is approximately 15 hours.
Dosing and administration
The medicine is used inside, without binding to eating. Taking the entire daily portion is usually recommended for 1 time - often this method is carried out in the morning.
The duration of the treatment cycle and the size of the dosage portions are selected by the treating doctor.
Usually for a day take the first pill medication. It can be used for long-term therapy.
During treatment with the use of drugs, you must constantly monitor the magnesium and calcium and sodium with potassium levels inside the plasma, as well as adjust the values of EBV, if necessary.
[11]
Use Indapene during pregnancy
In pregnancy, the drug is used only in cases where safer analogs did not have the desired effect.
Breastfeeding women should refrain from breastfeeding for the duration of the use of the medication.
Contraindications
The main contraindications:
- diagnosed intolerance of indapamide and other drugs from the sulfonamide category;
- use in people with deficiency of renal function in a pronounced form, against which background anuria is also noted;
- appointment to people with hepatic form of encephalopathy, disorders in the work of the liver (expressed degree), hypokalemia, and in addition with disorders in the thyroid gland.
It is very cautious to use the drug in diabetics or persons with gout (it is allowed only if the glucose values are regularly monitored with uric acid).
Caution is required when using the athletan in athletes, because its reception can provoke false positive readings during the passage of doping control.
Care should be taken when using drugs and people who manage potentially dangerous mechanisms, as well as drivers.
Side effects Indapene
The medication is usually tolerated by patients without negative consequences, but it is impossible to exclude the possibility of the appearance of side effects during treatment. Among the symptoms:
- disorders affecting the digestive function: nausea, dry mouth, mucosal disorders, stool disorders, pancreatitis, increased activity of liver enzymes and vomiting. People with liver failure have an increased incidence of liver encephalopathy (if the patient has symptoms of this disease, stop using drugs and conduct appropriate therapeutic procedures);
- lesions in the heart, blood vessels and hematopoietic system: orthostatic collapse, hemolytic or aplastic anemia, thrombocyto or leukopenia, as well as agranulocytosis;
- violations of the NA: dizziness, paresthesia, and in addition headaches and asthenia;
- indications of laboratory tests: an increase in the values of calcium, uric acid, glucose, plasma lipids, and in addition a decrease in the plasma magnesium and sodium and potassium;
- allergy symptoms: urticaria, maculopapular rashes and angioedema.
Also, during treatment with the drug in people with SLE there may be an exacerbation of manifestations of this pathology.
[10]
Overdose
The use of indapen in portions significantly exceeding the optimal recommended leads to the appearance of vomiting, pain in the epigastric zone and asthenia in patients, and in addition to suppression of respiratory activity, disorders of VEB indicators and a decrease in blood pressure.
The medication does not have an antidote. When poisoning should be performed gastric lavage and give the patient enterosorbents. Also, in case of overdose, it is necessary to monitor VEB values and monitor diuresis, and in addition to adjust electrolyte performance, if necessary. At the same time, during intoxication procedures are carried out, with the help of which the respiratory function and CCC activity are maintained.
Interactions with other drugs
Indapen can not be combined with other medicines that potentiate the process of potassium excretion.
It is forbidden to combine the medication with pentamidine, halofantrine, astemizole and terfenadine, and in addition with erythromycin (parenteral) and vincamin.
Combination with neuroleptics, baclofen or tricyclics causes potentiation of the antihypertensive properties of the drug.
The use together with ACEI leads to an increased likelihood of acute renal failure, as well as lowering blood pressure.
The simultaneous use of the drug with metformin can cause lactic acidosis.
The drug increases the likelihood of hypercalcemia when combined with calcium medicines.
Indapen is able to increase the toxicity of lithium drugs and digitalis medicines.
With caution, you need to combine the drug with antiarrhythmic drugs, cyclosporine, iodine-containing radiopaque substances and anti-inflammatory drugs of non-narcotic nature.
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Storage conditions
Indapen is required to be maintained at temperatures that are within the range of 15-25 ° C.
Shelf life
Indapen can be used within 3 years from the date of manufacture of the drug.
[13]
Application for children
The drug is not used in pediatrics.
[14]
Analogues
The analogues of the medication are Indapamide, Ionik, Arifon Retard and Enzyme, as well as Indopres and Ravel SR.
Reviews
Indapen perfectly copes with the task of normalizing blood pressure indicators. In addition, the reviews indicate that the drug does not cause the development of negative symptoms and has a fairly low cost. That is why it is considered a suitable tool for people who have problems with pressure.
Attention!
To simplify the perception of information, this instruction for use of the drug "Inhaled" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.