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Inflarax
Last reviewed: 04.07.2025

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Inflarax has anti-inflammatory, antimicrobial and analgesic activity.
Contains the component amikacin, which is a semi-artificial antibiotic from the aminoglycoside subgroup; has a wide range of therapeutic effects. Demonstrates a bactericidal effect - it passes through the walls of microbial cells, after which it is irreversibly synthesized with the 30S ribosomal subunit of the bacterium. In addition, the medicinal element also inhibits the binding of the protein, which is the causative agent of infection. [ 1 ]
Indications Inflarax
It is used in the following situations:
- in surgery: therapy of wounds of a purulent nature, during the 1st stage (purulent-necrotic) of the development of the lesion, to prevent suppuration on the surface and in the depth of the wound. It is also used in case of postoperative complications (surgery-related wound suppuration, fistula, phlegmon or abscess);
- in combustiology: therapy and prevention of suppuration of burns;
- in dermatology: therapy in case of development of epidermal lesions of a purulent-inflammatory nature ( pyoderma ).
Release form
The drug is released in the form of an ointment - in tubes of 15, 25, 50 or 100 g.
Pharmacodynamics
The drug has an intense effect on gram-negative aerobes: Escherichia coli, Serratia with Pseudomonas aeruginosa, Enterobacter, Salmonella, Shigella, Providencia Stuartii and Klebsiella.
Demonstrates activity against individual gram-positive microbes: staphylococci (including strains that are resistant to methicillin and penicillin, as well as individual cephalosporins) and individual streptococcal strains. [ 2 ]
Has no effect on anaerobes.
Benzalkonium Cl has a wide range of antimicrobial action against gram-negative and -positive bacteria, including intestinal and pseudomonas aeruginosa, as well as staphylococci. The principle of therapeutic action is based on the synthesis of the substance with ribosomes, resulting in irreversible suppression of protein binding. The drug is fixed in the area of cytoplasmic bacterial walls, destroying them; as a result, the cell begins to lose amino acids with potassium ions, as well as nucleotides.
Nimesulide exhibits anti-inflammatory (suppresses the inflammation stage, reducing the activity of inflammatory mediators, and also strengthens the walls of blood vessels) and analgesic effects (reduces tissue swelling, which leads to pain relief). [ 3 ]
Lidocaine slows down sensitive neuronal receptors of mucous membranes and epidermis, resulting in reverse suppression of conductivity through tissue components of nerve cells (axon with neuron and synapses). The substance inhibits the temporary increase in permeability for the passage of sodium ions, stimulated by the irritant, and also, less actively, reduces passive instability under the influence of sodium and potassium ions, which allows normalization of neuronal walls.
Lidocaine reduces the intensity of depolarization (response to a physiological stimulus), and with it the amplitude of the influence potential. It also inhibits neural conductivity processes. Lidocaine absorbed with local use can lead to depression or excitation from the CNS. The effect on the cardiovascular system develops in the form of conductivity disorders, as well as peripheral vasodilation.
Polyethylene oxide, which is a water-soluble ointment base, potentiates and prolongs the anti-inflammatory and antibacterial activity of the drug, demonstrating an intense and prolonged osmotic effect. As a result, the use of Inflarax allows eliminating perifocal edema and cleaning the wound from purulent-necrotic particles. The medicinal effect continues for 20-24 hours.
Dosing and administration
The affected areas should be treated with a thin layer of ointment, 1-2 times a day. You can also use sterile gauze wipes - soak them in the preparation, then apply to the wound surface. The required volume of the substance is selected taking into account the severity of pus exudation and the size of the wound. The ointment should be applied so that it covers the affected area completely.
In case of treatment of purulent wounds and epidermal lesions of purulent-inflammatory form, Inflarax is used daily.
During burns, the ointment is applied daily or 2-3 times a week (depending on the volume of pus released).
The duration of the therapeutic cycle is selected individually, taking into account the effectiveness of the drug and the size of the affected area. Dressings using ointment should be done until the wound is completely cleared of necrotic particles and pus.
- Application for children
There is no information regarding the medicinal efficacy and safety of Inflarax in pediatrics.
Use Inflarax during pregnancy
There is no information regarding the safety of using the ointment during breastfeeding or pregnancy.
Contraindications
Main contraindications:
- severe intolerance caused by the influence of drug components or local amide anesthetics;
- eczema or psoriasis;
- epidermal lesions of fungal origin;
- Prescription for people who take aspirin or other medications that slow down the binding of PG, causing the appearance of allergy symptoms (including urticaria, runny nose or bronchial spasm).
Side effects Inflarax
Side effects include local and allergic symptoms (including itching, swelling, epidermal rash, peeling, erythema and heartburn) and photosensitivity. Rarely, people with intolerance may experience anaphylactic symptoms, including vasomotor rhinitis, dyspnea, Quincke's edema and bronchial spasm.
When using the drug according to the recommendations and instructions, systemic disorders occur very rarely, because the volumes of the active element that can enter the bloodstream are extremely small. The use of large doses, a high rate of absorption of lidocaine or patient hypersensitivity, decreased tolerance and idiosyncrasy can lead to the occurrence of negative effects characteristic of local amide anesthetics used systemically.
Interactions with other drugs
After local treatment, no interaction of the drug with other drugs has been noted. But at the same time, it should be taken into account that when combining amikacin with benzylpenicillin, carbenicillin, and cephalosporins, mutual potentiation of therapeutic activity may occur. Nimesulide enhances the effect of substances that reduce blood clotting and sulfonamides; lidocaine - bupivacaine with novocaine.
Caution is required when using the drug with digoxin, lithium agents, anticoagulants, antihypertensive drugs, phenytoin, methotrexate, as well as NSAIDs, antiarrhythmic and antidiabetic agents. Local use of several NSAIDs at the same time can provoke local irritation - redness or peeling of the epidermis and urticaria.
Anti-inflammatory drugs (aminoquinolones with gold drugs) and GCS potentiate the anti-inflammatory activity of nimesulide.
Benzalkonium Cl is not chemically compatible with soap, other anionic surfactants and iodine substances. At the same time, nonionic surfactants weaken or completely eliminate the antimicrobial effect of benzalkonium Cl.
Storage conditions
Inflarax should be stored in a place closed to small children. Temperature indicators are within the 25°C mark.
Shelf life
Inflarax can be used for a period of 2 years from the date of manufacture of the medicinal substance.
Analogues
The analogues of the drug are Levosin and Gentaxan with Fastin.
Attention!
To simplify the perception of information, this instruction for use of the drug "Inflarax" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.