Indowozin

Indovazin is used for rheumatic problems with the soft tissues of the body, namely, with tendovaginitis, bursitis, fibrositis, periarthritis. 

Indications Indowozin

Indovazin is used for rheumatic problems with the soft tissues of the body, namely, with tendovaginitis, bursitis, fibrositis, periarthritis. It is also shown in the presence of swelling after surgery, when getting contusions, dislocations, sprains. It is used in the therapy of thrombophlebitis, phlebitis, post-phlebitis states. Important in the complex treatment of venous insufficiency, which is characterized by lower limbs, allows to remove edema, pain and feeling of heaviness.

Release form

The drug Indovazin is available in the form of a gel yellow or yellow-brown in color. Used externally. The drug is packed in membrane aluminum tubes, forty-five grams each. The tube is placed in a cardboard box provided with the insert instruction. The medicinal product contains thirty milligrams of indomethacin, twenty milligrams of troxerutin, twenty-three grams of carbomer, 524.5 milligrams of Macrogol 400, two and a half milligrams of sodium benzoate, one hundred milligrams of propylene glycol, and three hundred milligrams of ethanol of 96 per cent.

Pharmacodynamics

Indovazin is a combined drug that is distinguished by the content of indomethacin and troxerutin.

Indomethacin has anti-inflammatory, analgesic and anti-edema effects. All of the above contributes to a reduction in pain and swelling, as well as an increase in the rate of regeneration of tissues. The active ingredient acts as a substance that suppresses the production of prostaglandins by blockade of zikorgksigenazy 1 and 2, which is reversible.

Troxerutin is a bioflavonoid that has angioprotective properties. The substance helps to reduce the permeability of capillaries and has a venotonic effect. The active component contributes to blocking the venodilating action of histamine, which reduces the level of fragility of the capillaries. There is also some antiaggregant effect. There is a decrease in puffiness, trophic is improving, which is present in pathological changes that cause venous insufficiency.

The drug Indovazin helps suppress inflammatory edematous reactions, eliminate painful sensations, and also normalizes the local temperature of the surface and underlying tissues at the site of application. In this case, there is an effect on the blood vessels that are located in this area. The medication has a venotonic and capillaroprotective effect.

Pharmacokinetics

The use of the ointment base of the drug promotes the solubility and release of active substances such as indomethacin and troxerutin. These components are perfectly absorbed into the skin, which contributes to a good therapeutic effect of the drug. External use of the drug Indovazin by rubbing into the skin leads to the appearance of concentrations of active substances in the subcutaneous tissue, as well as in the periarticular tissues, which are therapeutic. The concentrations of active components of the medicament that can penetrate the circulatory system are not significant.

Dosing and administration

Indovazin is used externally. Four or five centimeters of the drug is applied a thin layer on the desired area of the skin with the help of light rubbing movements. The procedure is carried out three to four times a day. The total amount of gel per day should not be more than twenty centimeters. The course of therapy is no more than ten days.

Use Indowozin during pregnancy

Indovazin should not be used during pregnancy and lactation, because there is no information about the effect of the drug on the woman and fetus. The use of the gel is possible only after the doctor assesses the benefits to the mother with a low risk for the fetus or the baby.

Contraindications

• Child age is less than fourteen years.
• The presence of high sensitivity to the components of the drug.
• The patient's high sensitivity to non-steroidal anti-inflammatory drugs
• There is a history of bronchial asthma, allergic rhinitis and other atopic reactions.
• Limited in time, the drug is used by patients with severe hepatic and renal diseases, as well as peptic ulcer diseases of the gastrointestinal tract.
• The drug is not intended for use on open wounds, mucous membranes, oral cavity, eye conjunctiva.

Side effects Indowozin

• Usually the drug is well tolerated by patients.
• Perhaps the emergence of local reactions - itching, redness of the skin, contact dermatitis, rashes, feelings of warmth and burning sensation.
• The digestive system is the appearance of nausea and vomiting, pain in the stomach, as well as an increase in the level of the hepatic enzymes.
• Immune reactions - the emergence of anaphylaxis, an asthmatic attack, angioedema.

Overdose

• There is no information about an overdose of the drug.
• Long-term use of the drug - more than ten days - requires constant monitoring of the patient, as uncontrolled treatment can lead to the development of hepatotoxicity, as well as hemorrhages. It is important to monitor the level of leukocytes and platelets in the laboratory.
• Accidental administration of the drug inside has a burning effect on the mucous membrane of the mouth and stomach. This leads to increased salivation, as well as the occurrence of nausea and vomiting. In this case, it is recommended to wash the mouth and stomach. Symptomatic therapy may be prescribed.
• The injection of the drug into the eyes, as well as to other mucous membranes and wound surfaces leads to the appearance of tear, reddening of the affected area, the occurrence of burning and pain sensations. In this case, it is important to rinse the area with an abundant amount of distilled water or saline until the complaints decrease or disappear at all.

Interactions with other drugs

It is forbidden to use Indovazin and corticosteroid drugs at the same time, because such an application potentiates the ulcerogenic effect.

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Storage conditions

Indovazin - in a dry place, which is not accessible to children of children, at an air temperature below 25 ° C.

Shelf life

Indovazin is stored for 2 years from the date of manufacture.

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