Indovazine

Indovazin is used for rheumatic problems with soft tissues of the body, namely tendovaginitis, bursitis, fibrositis, periarthritis.

Indications Indovazine

Indovazin is used for rheumatic problems with soft tissues of the body, namely, tendovaginitis, bursitis, fibrositis, periarthritis. It is also indicated for swelling after operations, contusions, dislocations, sprains. It is used in the treatment of thrombophlebitis, phlebitis, post-phlebitic conditions. It is important as part of the complex treatment of venous insufficiency, which is characteristic of the lower extremities, it helps relieve swelling, pain and a feeling of heaviness.

Release form

The drug Indovazin is produced in the form of a yellow or yellow-brown gel. It is used externally. The drug is packaged in membrane aluminum tubes, forty-five grams each. The tube is placed in a cardboard package supplied with an instruction leaflet. The specified amount of the drug contains thirty milligrams of indomethacin, twenty milligrams of troxerutin, twenty-three grams of carbomer, 524.5 milligrams of macrogol 400, two and a half milligrams of sodium benzoate, one hundred milligrams of propylene glycol, three hundred milligrams of ethanol 96%.

Pharmacodynamics

Indovazin is a combination drug that contains indomethacin and troxerutin.

Indomethacin has anti-inflammatory, analgesic and anti-edematous effects. All of the above helps reduce pain and swelling, as well as increase the rate of tissue regeneration. The active component acts as a substance that suppresses the production of prostaglandins by blocking cicorroxygenase 1 and 2, which is reversible.

Troxerutin is a bioflavonoid that has angioprotective properties. The substance helps reduce capillary permeability and has a venotonic effect. The active component helps block the venodilating effect of histamine, which reduces the level of capillary fragility. Some antiplatelet effect is also observed. There is a decrease in swelling, trophism, which is present in pathological changes caused by venous insufficiency, improves.

The drug Indovazin helps suppress inflammatory edematous reactions, eliminates pain, and normalizes the local temperature of superficial and deep tissues at the site of its application. At the same time, it has an effect on the blood vessels located in this area. The drug has a venotonic and capillary-protective effect.

Pharmacokinetics

The use of the ointment base of the drug promotes the solubility and release of such active substances as indomethacin and troxerutin. These components are perfectly absorbed into the skin, which contributes to a good therapeutic effect of the drug. External use of the drug Indovazin by rubbing into the skin leads to the appearance in the subcutaneous tissue, as well as in the periarticular tissues of concentrations of active substances that are therapeutic. The concentrations of the active components of the drug that can penetrate the circulatory system are not significant.

Dosing and administration

Indovazin is used externally. Four or five centimeters of the preparation is applied in a thin layer to the desired area of the skin using light rubbing movements. The procedure is carried out three to four times a day. The total amount of gel per day should not exceed twenty centimeters. The course of therapy is no more than ten days.

Use Indovazine during pregnancy

Indovazin should not be used during pregnancy and lactation, since there is no information on the effect of the drug on the body of a woman and fetus. The use of the gel is possible only after the doctor has assessed the benefits for the mother with a low risk to the fetus or child.

Contraindications

• Children under fourteen years of age.
• The presence of high sensitivity to the components of the drug.
• The patient has a history of high sensitivity to non-steroidal anti-inflammatory drugs
• History of bronchial asthma, allergic rhinitis and other atopic reactions.
• The drug is used for a limited time by patients with severe liver and kidney diseases, as well as ulcerative diseases of the gastrointestinal tract.
• The drug is not intended for use on open wounds, mucous membranes, oral cavity, conjunctiva of the eyes.

Side effects Indovazine

• The drug is usually well tolerated by patients.
• Local reactions may occur - itching, redness of the skin, contact dermatitis, rash, feeling of warmth and burning sensation.
• Digestive system – the appearance of nausea and vomiting, stomach pain, and an increase in the level of liver enzymes.
• Immune reactions – occurrence of anaphylaxis, asthma attack, angioedema.

Overdose

• There is no information about drug overdose.
• Long-term use of the drug - over ten days - requires constant monitoring of the patient, since uncontrolled treatment can lead to the development of hepatotoxicity, as well as hemorrhages. It is important to monitor the level of leukocytes and platelets in laboratory conditions.
• Accidental ingestion of the drug causes a burning effect on the mucous membrane of the oral cavity and stomach. This leads to increased salivation, as well as nausea and vomiting. In this case, it is recommended to rinse the oral cavity and stomach. Symptomatic therapy may be prescribed according to indications.
• Contact of the drug with the eyes, as well as other mucous membranes and wound surfaces, leads to the appearance of lacrimation, redness of the affected area, burning and pain. In this case, it is important to rinse the specified area with a large amount of distilled water or saline solution until the complaints decrease or disappear completely.

Interactions with other drugs

It is prohibited to use Indovazin and corticosteroid drugs simultaneously because such use potentiates the ulcerogenic effect.

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Storage conditions

Indovazin - in a dry place, inaccessible to children, at an air temperature below 25C°.

Shelf life

Indovazin is stored for 2 years from the date of production.

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