Indapamide

Indapamide belongs to the group of antihypertensive and diuretic drugs.

[1], [2], [3], [4]

Indications of the indapamide

It is used to reduce elevated blood pressure values.

Such forms of drugs as Indapamid Teva, Indapamid Retard, and Indapamide MB Stade and others are used to treat CHF and hypertension, which has a moderate degree of severity.

[5], [6]

Release form

The drug is manufactured in tablets with a volume of 1.5 (Indapamide MB Stada and Indapamid Retard), as well as 2.5 mg (Indapamide) and 2.5 mg capsules (Indapamide Verte).

Packing - 10 pieces inside the blister plate. In the box there are 3 such plates.

[7]

Pharmacodynamics

The medicinal properties of the drug are similar to the mechanism of action of diuretics of the thiazide type. Indapamide increases the values of chlorine, sodium ions, potassium, and magnesium in the urine. In addition, it increases the elasticity of arterial membranes and gently weakens the resistance of peripheral vessels. Has no effect on the lipid levels inside the blood and the metabolism of carbohydrates. Helps reduce hypertrophy of the left heart ventricle.

The drug stimulates the production of P2 E2, and in addition has a significant effect on the production of free oxygen radicals.

[8], [9], [10],

Pharmacokinetics

The drug effect develops half an hour after ingestion (with a bioavailability level of approximately 93%) and persists for 24 hours. Peak values within the blood are observed after 12 hours after the tablet dissolves inside the digestive tract.

The half-life of the substance is 18 hours. Eating can increase the suction time a little, but the mastery of the medication remains full.

In the form of metabolic products through the kidneys, up to 80% of drugs are excreted, and about 20% through the intestine.

[11], [12], [13], [14], [15],

Dosing and administration

The medication is used, exactly following the instructions - a single dose per day (recommended in the morning), in the amount of the 1st capsule or tablet.

The medication can be combined with other antihypertensive drugs, but only the doctor who treats can select a scheme for such combinations.

It should be noted that Indapamide in the form of Retard has a longer, while a softer effect of the reagent - this is due to the fact that the release of the active element of the drug occurs with a slowdown.

Duration of drug use is determined by the doctor, taking into account the severity of hypertension. It should be noted that in medical practice, the drug is referred to as medicines prescribed for prolonged use (sometimes throughout life).

[20], [21], [22], [23], [24]

Use of the indapamide during pregnancy

It is prohibited to prescribe indapamide to pregnant women.

Contraindications

The main contraindications:

• the presence of liver or kidney failure;
• an allergy to sulphonamide derivatives;
• diabetes mellitus or anuria;
• women breastfeeding;
• pre-infarction state.

[16]

Side effects of the indapamide

As a diuretic medicine, Indapamide is able to reduce the calcium values inside the blood serum, as well as the sodium values, which causes dehydration. This can lead to the appearance of such side effects as headaches, constipation, allergy manifestations, nausea and dryness of the oral mucosa.

Occasionally there is a development of hemolytic form of anemia and a disorder of the heart rhythm.

[17], [18], [19]

Overdose

The poisoning of the drug occurs when you use a dose of 40 mg. Intoxication is expressed in the form of nausea, dryness of the oral mucosa, sensation of drowsiness, vomiting and a sharp decrease in blood pressure.

In case of an overdose, it is necessary to take urgent measures - wash the patient's stomach, restore the electrolyte balance and rehydrate (performed exclusively at the hospital).

[25]

Interactions with other drugs

Combination with antipsychotics or antidepressants potentiates the antihypertensive effect of drugs, and also increases the risk of orthostatic collapse.

SG, aluretics and laxative drugs potentiate the likelihood of a lack of potassium. When combined with erythromycin, tachycardia accompanied by ventricular fibrillation may develop. SCS and NSAIDs reduce the antihypertensive effect of indapamide. Iodine-containing medicines can cause dehydration. Combination with cyclosporine leads to the occurrence of hypercreatininaemia.

[26], [27], [28]

Storage conditions

Indapamide should be kept in a place that is closed from children and penetration of moisture. Temperature marks - not higher than 25 ° С.

[29], [30]

Shelf life

Indapamide can be used for 3 years since the release of the drug.

[31], [32]

Application for children

The medication is not prescribed for persons under the age of 18.

Analogues

Analogues of the drug are such drugs: Lorvas, Oxodolin, Indapen with Acrylamide, as well as Cyclomethiazide, Hydrochlorothiazide and Indopres.

[33], [34], [35], [36], [37]

Reviews

Indapamide generally receives good reviews about its drug exposure. Most hypertensive patients tolerate the drug without developing complications. This fact is confirmed by the responses of both patients and doctors and discussions at forums dedicated to the treatment of hypertension.

Negative manifestations develop quite rarely and have a weak degree of severity. Many hypertensives use this medicine all their life.