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Immunophane
Last reviewed: 03.07.2025
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[ Indications Immunofan
It is used in the process of complex therapy in conditions of immunodeficiency or intoxication, as well as in chronic inflammations of various origins. It is also used in adults in adjuvant treatment during vaccination against viruses and bacterial infections.
Release form
Released as a solution for subcutaneous and intramuscular injections, in 1 ml ampoules. Inside the blister there are 5 such ampoules. In a separate pack there is 1 blister with ampoules.
Pharmacodynamics
The active substance of the drug is a hexapeptide with a molecular weight of 836D. The drug has detoxifying, immunomodulatory, and hepatoprotective properties, and promotes the inactivation of peroxide and free radical bonds. The effect of this peptide immunooxidizer is due to the achievement of 3 main effects of the drug: restoring the balance between oxidation-reduction processes within the body, correcting the immune function, and slowing down multiple drug resistance mediated by transmembrane transporter proteins.
The effect of the drug on the production of specific antibodies with antibacterial and antiviral activity corresponds to the effect of medicinal vaccines. But Immunofan, unlike vaccines, has a weak effect on the production of reagins and immunoglobulins from the IgE subclass, without increasing the immediate manifestation of hypersensitivity. The drug promotes the formation of immunoglobulins included in the IgA subclass if a person has a congenital deficiency of them.
Immunofan is highly effective in combating multiple resistance of tumor cells to various drugs and also increases their sensitivity to the effects of cytostatics.
Pharmacokinetics
The drug is completely absorbed from the injection site, after which it undergoes rapid breakdown into natural amino acids, which are its constituent elements.
The development of the drug effect begins after 2-3 days (in the rapid phase) and lasts for up to 4 months (in the moderate and slow phases).
During the rapid stage, which lasts about 2-3 days, the detoxifying effect of the drug develops first of all – the antioxidant protective function of the body increases (by stimulating the production of lactoferrin with ceruloplasmin and increasing the activity of catalase). The drug helps stabilize the process of lipid peroxidation, slows down the breakdown of phospholipids located inside the cell membrane, as well as the binding of arachidonic acid, which results in lower cholesterol levels and the production of inflammatory conductors. In the case of an infectious or toxic disorder with an effect on the liver, the drug prevents cytolysis and reduces serum bilirubin levels along with transaminase activity.
During the middle phase, which begins after 2-3 days and lasts no more than 7-10 days, the action of phagocytosis is potentiated and the number of dying viruses and bacteria increases. Due to the activation of phagocytosis processes, the inflammatory reaction of a chronic type, supported by the persistence of bacterial or viral antigens, may slightly worsen.
During the slow stage of the drug action, which begins after 7-10 days and lasts up to 4 months, the main values of humoral and cellular immune reactions are stabilized. During this period, the immunomodulatory index is restored, the production of specific antibodies increases, etc.
Dosing and administration
The solution is administered intramuscularly or subcutaneously. The medicine should be used in courses.
A single daily dose of the drug for children over 2 years of age and adults is 1 ml (50 mcg). The attending physician prescribes the duration of the therapeutic course, taking into account the severity of the disease, the characteristics of its course, and in addition, the effectiveness of the drug and its tolerability by the patient.
Below are described the standard treatment regimens that are recommended for administration of the drug to the patient.
During the treatment of oncological pathologies (as an adjuvant in complex therapy - in combination with surgery and chemotherapy): administer injections every day, 1 time. Before chemotherapy, as well as before the operation, it is necessary to administer 8-10 injections of the solution, and then continue to use the medicine throughout the entire period of therapy.
During symptomatic or combined treatment in individuals with cancerous tumors at stage 3-4 of the disease, having different locations: administration of the solution every day once a day. The course includes 8-10 injection procedures, and then a break of 15-20 days is required, after which the above course is repeated. This treatment regimen is used throughout the entire period of therapy.
For children diagnosed with malignant diseases in the lymph or hematopoietic system: injections are administered once a day, and the entire course of therapy includes 10-20 injection procedures. The administration of the solution must be prescribed throughout the entire course of chemotherapy, and then after its completion - as a means of preventing the occurrence of toxicosis.
In case of combined treatment – for children with papillomatosis in the area of the oropharynx with larynx: make injections once a day according to the scheme every other day. During the course, it is necessary to perform 10 procedures of solution administration.
During treatment of opportunistic infectious lesions (such as toxoplasmosis, herpes or cytomegalovirus infections, pneumocystis pneumonia, chlamydia and cryptosporidiosis): one injection per day, the drug is administered every day. The course consists of 15-20 injection procedures.
In complex treatment of infections of the HIV type: 1 injection every day. The entire course includes 15-20 injection procedures. If necessary, repeated courses can be performed, taking breaks between them lasting 2-4 weeks.
In combination with other drugs for the treatment of viral hepatitis (chronic type) or chronic brucellosis: 1 injection of the solution every day, 15-20 injections are required per course. To prevent relapses, a repeat therapeutic course must be administered every 2-3 months.
To eliminate diphtheria: 1 injection should be administered daily, a total of 8-10 procedures should be performed during the course. If a person is a diphtheria carrier, the solution should be administered once every 3 days. A total of 3-5 injection procedures should be performed.
As an auxiliary drug during the treatment of persons with severe burns, as well as signs of toxemia (with the development of septicotoxemia), with complications of a purulent-septic nature or injuries in the limbs, and in addition to this for surgical patients suffering from the septic form of endocarditis: daily administration of 1 injection of the solution, 8-10 procedures are performed during the entire course. If necessary, the course can be extended to 20 procedures.
During chronic obstructive pulmonary diseases, as well as cholecystopancreatitis: injections are performed once every three days. 8-10 injections are performed per course. It is allowed to extend the therapy to 20 injection procedures, which are performed at the above-mentioned intervals.
Combined use for eliminating psoriasis: daily injections (1 time). The entire course of therapy consists of 15-20 procedures.
For adults during preventive vaccination: a single injection of the solution on the day of vaccination.
Use Immunofan during pregnancy
The drug should be prescribed to pregnant women (if there is no risk of Rh conflict with the fetus), as well as to nursing women, taking into account the risks to the child/fetus, as well as their ratio in comparison with the benefits of its use for the woman.
Contraindications
Contraindications include: intolerance to any of the components of the medication, and in addition, children under 2 years of age.
Special instructions
Reviews
Immunofan is considered to be a fairly effective and fast-acting medicine. Patients note that after the first procedure of administering the solution, their condition improves. Reviews show that the medicine is most effective in eliminating pathologies of viral or infectious origin.
Shelf life
Immunofan can be used for a period of 2 years from the date of release of the drug.
Attention!
To simplify the perception of information, this instruction for use of the drug "Immunophane" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.