The medicine should be consumed orally. Adults, and together with this elderly people, need a minimum dosage, which gives a medicinal effect (it is not allowed to be above 6.5 mg / kg (the calculation is based on the ideal and not actually available weight) per day and is usually 200 or 400 mg).
People who are allowed to consume 400 mg of medicine per day - at the initial stage this dosage should be divided into 2 separate receptions. If there are no noticeable signs of improvement, it is allowed to reduce it to 200 mg. If the drug works effectively, you can increase the daily maintenance dosage to a value of 400 mg.
Children are prescribed a minimally effective daily dosage (no more than 6.5 mg / kg of ideal weight value). It is because of this that it is forbidden to prescribe medication in 200 mg tablets to children whose ideal weight is less than 31 kg.
During elimination of attacks of malaria - for adults the dosage is equal to 400 mg on the same days of the week. In childhood (children weighing 31+ kg), a weekly dosage for an attack is 6.5 mg / kg, but it can not exceed the recommended adult dosage, regardless of weight.
If circumstances permit, overwhelming treatment should be started 2 weeks before the trip to the area of endemia distribution. In the absence of such an opportunity for adults, a double loading dose is prescribed (800 mg), and for children - 12.9 mg / kg weight (but not more than 800 mg), which is divided into 2 separate doses with an interval of 6 hours. Suppressive therapy should be continued 8 weeks after the person has left the endemic area.
Treatment in case of acute malarial attacks. The size of the initial adult dosage is 800 mg, followed by 400 mg every 6-8 hours for the next 2 days (on the whole, 2 g of the active ingredient of the drug is obtained). As an effective alternative, you can use a single dose of LS at a dosage of 800 mg. You can count on it, given the weight (as for the child).
Children with an ideal weight of 31+ kg - the total dosage is 32 mg / kg (but maximum 2 g), it should be taken for 3 days, taking into account the additions described below:
- initial - 12.9 mg / kg (but with a single dose of no more than 800 mg);
- 2 nd - 6.5 mg / kg (but with a maximum of 400 mg) 6 hours after the use of the initial dosage;
- 3rd - 6.5 mg / kg (maximum 400 mg) 18 hours after the use of the 2nd dosage;
- 4th - 6.5 mg / kg (maximum size 400 mg) 24 hours after the use of the 3rd dosage.
All tablets should be consumed with food or by washing them with milk (1 glass).
Hydroxychloroquine is able to accumulate in the body, so several weeks are needed to get the drug, but weak negative reactions can appear quite early. In the case when in the treatment of rheumatic pathologies for six months there is no improvement in the patient's condition, it is recommended to stop the course.
In the treatment of pathologies associated with intolerance to light, it is required to limit therapeutic courses exclusively to periods of constant exposure to light.