As a result of using the cream, the following side effects can develop.
Subcutaneous tissue, as well as the skin: intolerance of the active components of the drug, and also any of the auxiliary elements is possible. With such a reaction, you must cancel the use of drugs. The reaction of hypersensitivity to clotrimazole can manifest itself in the form of such symptoms: burning, irritation, redness and itching with swelling on the skin. In addition, there are also watery blisters, blisters, scaling, rashes, pain and discomfort. There may be fever or urticaria, and with it allergic manifestations (such as dyspnoea, fainting and decreased blood pressure).
Hexamidine is able to cause sensitization, the risk of developing it increases depending on the increase in the strength of lesions of the skin. A drug-induced contact type of dermatitis is associated with the Arthus phenomenon, which may be a sign of involvement in this process of humoral immunological reactions. In this case, the clinical signs of the disease often differ from the standard eczema of the contact type: rashes mainly with infiltrates, on the skin you can see vesicular or papular hemispherical formations that are grouped in one place or isolated from each other. There are so many of them on the application areas of the disinfectant that they can even merge with each other. Usually such a rash is very slow. After local use, there may also occur systemic allergic manifestations.
Perhaps the emergence of local reactions to corticosteroids - swelling, rashes, hyperemia, urticaria and purpura in the treatment site. In addition, the appearance of burning, dryness, irritation and itching. After prolonged use of the cream, atrophy or telangiectasia often develops, stretch marks, steroid type acne, bleeding, a perioral type of dermatitis resembling rosacea, and hypertrichosis in addition. Continuous use of the cream can cause the emergence of secondary infectious processes in the skin.
Endocrine system: as a result of prolonged application to extensive areas of the body, the development of systemic exposure is possible. Among the violations: depression of the internal synthesis of corticosteroids, hypercorticosis with swelling, stretching atrophic type, development of latent diabetes, and in addition, osteoporosis, as well as stunting in children. But the development of such symptoms is almost impossible for weak corticosteroids, in which the group includes prednisolone acetate.
The medicine contains butylhydroxyanisole (or E 320), which can provoke local skin reactions (for example, contact form of dermatitis) or eye irritation along with mucous membranes.