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Ibuprom
Last reviewed: 03.07.2025
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The main active ingredient of Ibuprom is ibuprofen, which is a synthetic substance derived from propionic acid.
Indications Ibuprom
Indications for the use of Ibuprom suggest the use of this drug as a medicinal product with anti-inflammatory and analgesic action.
It is advisable for a number of diseases of the musculoskeletal system of a degenerative and inflammatory nature. It is prescribed for arthritis in chronic form, rheumatoid, psoriatic and juvenile types. The drug is also indicated for inclusion in the composition of complex therapeutic measures against arthritis in case of systemic lupus erythematosus. In addition, this drug is justified (in its fast-acting medicinal forms) when an acute gouty attack occurs with gouty arthritis.
Prerequisites for the appointment of this medication are, in addition: the presence of osteochondrosis; Parsonage-Turner disease (neuralgic amyotrophy); ankylosing spondylitis - Bechterew's disease.
Ibuprom is used to relieve pain in arthritis and arthralgia, myalgia, ossalgia, radiculitis, bursitis, neuralgia, tendinitis and tendovaginitis. It also finds application against migraines, headaches and toothaches, pains that accompany the development of various types of malignant lesions.
The use of Ibuprom helps reduce the severity of pain syndrome arising as a result of exposure to traumatic factors. In the period after surgery, the drug can also reduce the intensity of pain due to postoperative inflammation.
The use of this drug is indicated in the development of inflammatory processes in the pelvic area, adnexitis, algomenorrhea, and febrile syndrome accompanying infectious and cold diseases. In addition, Ibuprom is used during labor as a tocolytic and analgesic agent.
Release form
The release form of Ibuprom is in the form of tablets with a white gastro-soluble coating. The tablets are round with a double-sided convex surface, on one side of which there is an embossed black inscription: IBUPROM.
One tablet contains 200 mg of ibuprofen.
In addition to the main active ingredient, there are a number of auxiliary ingredients. They are represented by the following components: powdered cellulose, pregelatinized starch, corn starch, structured polyvidone, talc, guar gum, colloidal silicon dioxide, hydrogenated vegetable oil.
The shell is formed by a combination of the following components: hydroxypropyl cellulose, macrogol (polyethylene glycol), talc, gelatin, sucrose, kaolin, a combination of sucrose and corn starch, sucrose as sugar syrup, calcium carbonate, acacia gum, titanium dioxide E171, carnauba wax, Opalux White AS 7000 (sodium benzoate E 211, sucrose, purified water).
The composition of special food ink Opacode S-1-17823 Black, which was used for applying the inscription, includes: shellac, isopropyl alcohol, n-butyl alcohol, 28% ammonia solution, propylene glycol, black oxide E172 iron (III).
2 tablets are packed in a sachet, 1 sachet in a cardboard box.
10 tablets in a blister, 1 blister in a cardboard box.
50 tablets in a polyvinyl bottle in a cardboard box.
As we can see, the drug, the release form of which is presented as film-coated tablets, can be found in a variety sufficient to select the most suitable of the proposed options for the prescribed course of treatment.
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Pharmacodynamics
The pharmacodynamics of Ibuprom is largely determined by the action of its main active ingredient - ibuprofen, a substance produced by synthesis from propionic acid.
The pharmacological effect of the drug, which belongs to the non-steroidal anti-inflammatory drugs, is characterized by the actualization of its analgesic, hypothermic and anti-inflammatory properties, due to the non-selective blocking of cyclooxygenase-1 and cyclooxygenase-2. In addition, the main pharmacological features of Ibuprom include the ability of this drug to act as an inhibitor in relation to the processes in which prostaglandins are synthesized.
The degree of expression of the analgesic effect produced by the drug is highest in cases of its use as a painkiller against pain associated with the development of the inflammatory process. It should be noted that the active properties of an intensive analgesic demonstrated by the drug are not characterized by a connection with the narcotic type of pain-relieving effect.
Like all other non-steroidal anti-inflammatory drugs, ibuprofen has antiplatelet activity.
To summarize all of the above, we also note that the pharmacodynamics of Ibuprom are such that it promotes the onset of pain-relieving action within a relatively short time, from 10 to 45 minutes after the drug has been taken.
Pharmacokinetics
One of the primary specific properties that distinguishes the pharmacokinetics of Ibuprom is the ability to be well absorbed in the gastrointestinal tract. The greatest degree of absorption occurs in the stomach and small intestine.
The bioavailability index is mostly at the 80 percent mark. The effect of food intake on the degree of absorption of the drug is insignificant, but some increase in the time required for absorption of the active ingredient - ibuprofen - is possible.
Ibuprofen has such a nature of interaction with proteins in blood plasma, in which it binds to the latter almost to an absolute degree - 99%. The drug reaches its maximum concentration in blood plasma after 45 minutes to one and a half hours after it was taken orally. The highest concentration formed by ibuprofen in synovial fluid significantly exceeds the maximum plasma concentration of the drug. This is explained by the existing difference in the concentrations in which albumin is present in biological fluids.
Metabolism occurs in the liver, where the drug is carboxylated and hydroxylated. As a result of the transformations, 4 pharmacologically inactive metabolites appear.
The half-life of a 200-mg dose occurs over a period of 120 minutes. There is a direct relationship between increasing dosage and half-life. Repeated and further use of Ibuprom causes an increase in the time required for that to 2-2.5 hours.
Pharmacokinetics of Ibuprom, as regards its excretion, has the following features: having the form of metabolites, it is excreted mainly by the kidneys, unchanged, leaving the body in an amount not exceeding 1%. A small part of the drug as metabolites is excreted in the bile.
Dosing and administration
The method of application and dosage of Ibuprom are regulated by certain norms and rules existing regarding the use of this medication. In what dosage this drug seems appropriate, as well as how long the course of treatment should be, is determined by the attending physician for each specific patient on an individual basis.
For adults and children (not earlier than when the child patient reaches 12 years of age), the recommended dose is 200 to 400 mg, taken three times a day.
Ibuprom should be taken during or after meals. In case of gastrointestinal diseases, or patients with a history of ulcerative-erosive lesions of the duodenum and stomach, as well as with a history of gastritis, the drug should be taken during meals.
The tablet does not need to be chewed; it should be swallowed whole with a sufficient amount of water, without being divided into several parts.
There is an important nuance regarding the interval between doses of the drug, namely, each subsequent tablet should be taken no earlier than after a period of time from the previous dose of 4 to 6 hours has passed.
There is no need to make any special adjustments to the dosage regimen of the drug when it is used by elderly patients.
Patients with acute renal and hepatic failure require a dose reduction.
In cases where the method of administration and dosage of the drug cause headache as a side effect, it is not permissible to resort to increasing the dosage in order to relieve an attack of such pain.
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Use Ibuprom during pregnancy
The use of Ibuprom during pregnancy is one of those cases when the drug should be avoided.
Regarding the period of lactation and breastfeeding, it is impossible to ignore the fact that ibuprofen, together with the products formed as a result of its metabolism, can be present in breast milk.
A woman must stop breastfeeding her baby in cases where high doses of Ibuprom are indicated, as well as if a long course of therapy with the drug is expected.
Contraindications
Contraindications to the use of Ibuprom are the following clinical cases: individual hypersensitivity to ibuprofen or any other component included in the drug.
Allergic reactions that occur as a consequence of the use of acetylsalicylic acid or any other nonsteroidal anti-inflammatory drugs make the use of this drug unacceptable. Thus, Ibuprom is contraindicated in Quincke's edema, bronchial asthma, rhinitis.
The use of the drug should be avoided if other non-steroidal anti-inflammatory drugs are already being used, including those that are specific cyclooxygenase-2 inhibitors.
The patient's medical history, burdened by at least two or more clear episodes of bleeding or exacerbation of gastric ulcer, as well as the presence of gastric ulcer at the present time, makes it inappropriate to prescribe the drug.
This medicine is not used in patients with a history of perforation or bleeding in the upper gastrointestinal tract that occurred in connection with the previous use of non-steroidal anti-inflammatory drugs.
Disturbances in the normal functioning of internal organs, such as severe failure of the heart, kidneys and liver are also contraindications to the use of Ibuprom.
Side effects Ibuprom
Side effects of Ibuprom are reflected in the gastrointestinal tract in the arising nausea, vomiting, heartburn, in the emerging disorders of the digestive process and stool, in the phenomenon of flatulence, painful sensations in the epigastrium. In some isolated cases, gastrointestinal bleeding, ulcerative lesions of the duodenum and stomach, ulcerative colitis, pancreatitis were noted. A certain probability of changes in the perception of taste buds is also not excluded.
With regard to liver function, the consequences of using the drug may include the development of hepatitis, increased liver enzyme activity, and liver failure.
In the central nervous system, Ibuprom can lead to such negative phenomena as headache, dizziness, and a state of excessive drowsiness.
The most common adverse symptom observed in the functioning of the cardiovascular system is increased heart rate, tachycardia. In those patients who had increased sensitivity to Ibuprom, and in addition, when other non-steroidal anti-inflammatory drugs were taken at the same time, hypertension developed in extremely rare cases and incipient heart failure was noted. The use of this drug is also associated with an increased risk of such arterial thrombotic events as stroke and myocardial infarction.
The body's hematopoietic system is capable of giving its response to the use of the drug as the development of anemia, leukopenia, pancytopenia and thrombocytopenia. Courses of treatment with this drug, which are distinguished by a long duration, are associated with the possibility of developing agranulocytosis, accompanied by ulcerative lesions of the oral mucosa, sore throat, fever and an increasing risk of bleeding.
The following changes occur in the urinary system: an increase in the presence of urea in the blood is observed, and a decrease in the daily volume of urine occurs. It is very rare to encounter such a phenomenon associated with the use of Ibuprom as papillary necrosis.
There is a possibility of developing allergic reactions in the form of urticaria, skin rashes, erythema multiforme and epidermal necrosis. There is also a possibility of anaphylactic shock and Quincke's edema.
Other side effects of Ibuprom are that in patients with any autoimmune diseases, aseptic meningitis may develop, with its characteristic symptoms: fever, headache, nausea, vomiting, stiff neck, impaired spatial orientation.
Overdose
Overdose of Ibuprom leads to the fact that patients who were given the drug in excessively high doses experience nausea, vomiting, dizziness, headache, develop gastralgia, and become drowsy and lethargic.
As a consequence of increasing the doses of this drug in the future, hypotension may begin to develop, hyperkalemia may develop. This is accompanied by fever, arrhythmia, the patient may lose consciousness, metabolic acidosis develops, renal function and respiratory processes are impaired, and a comatose state occurs.
The chronic nature of intoxication under the influence of the drug used irregularly, but in high doses over a long period of time, as noted, provoked hemolytic anemia, thrombocytopenia, granulocytopenia.
Since a specific antidote is unknown and hemodialysis is ineffective due to the high degree of protein binding in blood plasma, symptomatic therapy is chosen as the main treatment. The patient is also given enterosorbents and the stomach is washed.
In case of acute poisoning with the drug, the possibility that it will lead to metabolic acidosis cannot be discounted. Therefore, it is very important to carefully monitor the patient's condition and, as soon as the first symptoms are detected, to begin measures aimed at restoring the acid-base balance pH to 7.0-7.5 and stabilizing its level within these limits.
Until all the symptoms caused by overdose are eliminated, it is necessary to keep vital functions of the body under control. For example, by means of electrocardiography and control of blood pressure. In addition, not the least important role in this regard is given to the prevention of disturbances in the activity of the central nervous system and the possibility of bleeding in the gastrointestinal tract.
Interactions with other drugs
Given the nature of the interaction of Ibuprom with other drugs, its use in combination with other non-steroidal anti-inflammatory drugs requires caution, since in this case there is an increased risk that all sorts of side effects will occur in the hematopoietic system and in the gastrointestinal tract.
On the other hand, Ibuprom is acceptable in combination with any of those non-steroidal anti-inflammatory drugs that have a low degree of systemic action.
Glucocorticosteroids should not be prescribed simultaneously with this drug due to the possibility of mutual enhancement of the toxic properties of each of them.
Angiotensin-converting enzyme inhibitors and beta-blockers, as well as other antihypertensive agents, when interacting with ibuprofen, tend to reduce the degree of their effect.
The use of anticoagulants together with Ibuprofen necessitates regular monitoring of blood clotting parameters, due to the fact that ibuprofen reduces platelet aggregation.
The effectiveness of diuretics in combination with this drug is reduced. Thiazide and loop diuretics are subject to such effects, for example.
The combined use of lithium preparations with Ibupro requires monitoring of the blood for the content of this element, as it contributes to an increase in the concentration of the latter.
The drug is not prescribed to patients undergoing combination antiretroviral therapy for HIV that uses zidovudine.
Interactions of Ibuprom with other drugs, which, finally, must be said in relation to such a drug as methotrexate, are characterized by an increase in its, methotrexate’s, toxicity.
Special instructions
The key feature of the mechanism of action of this drug is as follows: under its influence, a violation of the metabolism of arachidonic acid occurs, as a consequence of the fact that the activity of the cyclooxygenase enzyme is suppressed, catalyzing processes characterized by the synthesis of endogenous biologically active substances from arachidonic acid. In particular, the drug acts as an inhibitor for the synthesis of prostaglandins E, F and thromboxane. As a result of its use, prostaglandins tend to show a tendency to reduce their amount in the tissues of the central nervous system and at the site of localization of the inflammatory process.
This drug is characterized by the fact that it non-selectively inhibits cyclooxygenase, the inhibition of which equally affects both isoforms accepted by this enzyme - cyclooxygenase-1 and cyclooxygenase-2. Since prostaglandins reduce their presence, in the area of the body subjected to inflammation, receptors become less sensitive to the effects of chemical irritants. Inhibition of prostaglandins synthesized in tissues in the central nervous system causes a systemic analgesic effect. By exerting an effect consisting in the fact that the synthesis of prostaglandins is inhibited in that part of the hypothalamus that is responsible for thermoregulation of the body, the drug used for fever demonstrates its antipyretic properties.
The synthesis of thromboxane from arachidonic acid is also inhibited, resulting in an antiplatelet effect.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Ibuprom" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.