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Ibuprom
Last reviewed: 23.04.2024
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The main active ingredient in Ibuprom is ibuprofen, which is a synthetic substance derived from propionic acid.
Indications Ibuprom
Indications for use Ibuprom suggest the use of this drug as a drug of anti-inflammatory and analgesic action.
It is expedient for a number of diseases of the musculoskeletal system of a degenerative and inflammatory nature. It is named after arthritis in chronic form, rheumatoid, psoriatic and juvenile type. The drug is also indicated for inclusion in complex therapeutic measures against arthritis in the case of systemic lupus erythematosus. In addition, this medication is justified (in its high-speed dosage forms), when gouty arthritis has an acute gouty attack.
Prerequisites for the appointment of this medication are, in addition: the presence of osteochondrosis; disease Persononeja-Turner (neuralgic amyotrophy); Ankylosing spondylitis - Bekhterev's disease.
Ibuprom is used to relieve pain in arthritis and arthralgia, myalgia, ossalgia, radiculitis, bursitis, neuralgia, tendinitis and tendovaginitis. It also finds its use against migraines, headaches and toothaches, pains that accompany the development of various types of malignant lesions.
The use of Ibuprom helps reduce the severity of the pain syndrome that occurs as a consequence of traumatic factors. In the period after the surgical intervention, the drug can also reduce the intensity of pain on the background of postoperative inflammation.
The use of this drug in the development of inflammatory processes in the pelvic region, with adnexitis, algodismenorrhea, with febrile syndrome associated with infectious and catarrhal diseases is shown. In addition, Ibuprom is used during labor as a tocolytic and anesthetic.
Release form
Form of release Ibuprom has the form of tablets coated with a gastro-dissolving coat of white color. Tablets have a round shape with a bilaterial convex surface, on one side of which there is an embossed black inscription: IBUPROM.
One tablet contains ibuprofen 200 mg.
In addition to the active active principle, there are a number of auxiliary ingredients. They are represented by the following constituents: cellulose powder, pregelatinized starch, corn starch, structured polyvidone, talc, guar gum, colloidal silicon dioxide, vegetable oil hydrogenated.
The shell is formed by a combination of such components: hydroxypropylcellulose, macrogol (polyethylene glycol), talc, gelatin, sucrose, kaolin, a combination of sucrose and corn starch, sucrose as sugar syrup, calcium carbonate, Arabian gum, titanium dioxide E171, carnauba wax, Opalux White AS 7000 sodium benzoate E 211, sucrose, purified water).
In the special food ink Opacode S-1-17823 Black, which were used for inscription, include shellac, isopropyl alcohol, n-butyl alcohol, ammonia solution 28%, propylene glycol, black oxide E172 iron (III).
Tablets in the quantity of 2 pieces are packed in a sachet, 1 sache in a box of cardboard.
Tablets of 10 pieces in a blister, 1 blister in a cardboard package.
50 tablets in a vial of polyvinyl acetate in a cardboard box.
As we see the drug, the form of which is presented as a coated tablet can be found in a variety sufficient to choose the most suitable of the proposed options for a prescribed course of treatment.
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Pharmacodynamics
The pharmacodynamics of Ibuprom is due in no small measure to the action of its main active ingredient, ibuprofen, a substance produced by synthesis from propionic acid.
The pharmacological effect of the drug belonging to the anti-inflammatory drugs of the nonsteroid group is characterized by the actualization of its analgesic, hypothermic and anti-inflammatory properties, due to the indiscriminate blocking of cyclooxygenase-1 and cyclooxygenase-2. In addition, one of the main pharmacological features of Ibuprom is the ability of this medication to act as an inhibitor to the processes in which prostaglandins are synthesized.
The degree of expression of the analgesic effect produced by the preparation is highest in cases of its use as an analgesic against pain associated with the development of the inflammatory process. It should be noted that the active properties of the intensive analgesic developed by the drug are not characterized by a relationship with the narcotic type of analgesic action.
Like all other non-steroidal anti-inflammatory drugs, ibuprofen has antiplatelet activity.
Summarizing all of the above, we also note that the pharmacodynamics of Ibuprom is such that it helps to start the analgesic action for a relatively short time, from 10 to 45 minutes after the drug was taken.
Pharmacokinetics
One of the primary specific properties that distinguish the pharmacokinetics of Ibuprom is the ability to be absorbed well in the gastrointestinal tract. The highest degree of absorption takes place in the stomach and in the small intestine.
The bioavailability indicator is mainly at the level of 80%. The effect of food intake on the degree of absorption of the drug is negligible, but it may be some increase in the time required for absorption of the active active ingredient, ibuprofen.
Ibuprofen is characterized by a character of interaction with proteins in the blood plasma, at which its binding to the latter occurs in an almost absolute degree - by 99%. The drug comes to its maximum concentration in the blood plasma after a period of 45 minutes to one and a half hours after it was taken orally. The highest concentration formed by ibuprofen in the synovial fluid greatly exceeds the maximum plasma concentration of the drug. The explanation for this is the existing difference in concentrations in which albumin is present in biological fluids.
Metabolization occurs in the liver, where the drug is carboxylated and hydroxylated. As a consequence of the transformation, 4 pharmacologically inactive metabolites appear.
The half-life of the 200-milligram dose occurs over a time period of 120 minutes. There is a direct relationship between the increase in dosage and half-life. The repeated and further use of Ibuprom induces an increase in the required for that time to 2-2 and a half hours.
The pharmacokinetics Ibuprom, with regard to its excretion, has such features: having a kind of metabolites is excreted mainly by the kidneys, it leaves the body without changes, in an amount not exceeding 1%. A small part of the drug as metabolites undergoes excretion in the bile.
Dosing and administration
The way of administration and dose of Ibuprom is regulated by certain norms and rules existing with regard to the use of this medication. In what dosage is this medication appropriate, and how long should the treatment course be determined by the attending physician for each individual patient individually.
For adults and children (not earlier than when a child-12-year-old is reached), the recommended dose is from 200 to 400 mg, which is appropriate for taking three times a day.
It is necessary to take Ibuprom during or after a meal. In diseases of the gastrointestinal tract, or patients with an anamnesis with ulcerative and erosive lesions of the duodenum and stomach, as well as gastritis in a history of taking the drug should occur during meals.
The tablet does not need to be chewed, swallowing it, squeezed with enough water, should be wholly, not divided into several parts.
There is an important nuance regarding the interval between taking doses of the drug, namely - each subsequent tablet should be taken no earlier than after a period of time from the previous reception from 4 to 6 hours.
Any special adjustment of the dosage regimen, when used by patients in old age, is not necessary.
Patients with acute renal and hepatic insufficiency need to reduce the dose
In those cases when the method of administration and dose of the drug cause a headache as side effects, in order to stop the attack of such pain it is not allowed to resort to an increase in dosage.
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Use Ibuprom during pregnancy
The use of ibuprom during pregnancy is one of the cases when one should refrain from prescribing the drug.
Regarding the period of lactation and breastfeeding - here we can not ignore the fact that ibuprofen, together with the products formed as a result of its metabolism is able to be present in the composition of breast milk.
Refuse to breastfeed a woman is required in cases when high doses of Ibuprom are indicated, and also if a prolonged course of therapy with the use of the drug is expected.
Contraindications
Contraindications to the use of Ibuprom are the following clinical cases: individual hypersensitivity to ibuprofen or to any other component that leads to the drug.
It is unacceptable to use this drug allergic reactions that arise as a consequence of the fact that acetylsalicylic acid or some other of the non-steroidal anti-inflammatory drugs has been used. Thus, Ibuprom is contraindicated in the case of Quincke's edema, bronchial asthma, rhinitis.
Use of the drug should be avoided if other non-steroidal anti-inflammatory drugs are already being used, including those that are specific inhibitors of cyclooxygenase-2.
Anamnesis of the patient, burdened with at least two or more, clear episodes of bleeding or exacerbation of the gastric ulcer, as well as the presence of peptic ulcer of the stomach at the current time causes the inappropriateness of prescribing the drug.
This medication is not applied to those patients whose history includes perforation or perforation, as well as bleeding in the upper gastrointestinal tract that occurred in connection with the use of previously non-steroidal anti-inflammatory drugs.
Violations of the normal activity of internal organs, such as severe failure of heart, kidney and liver function also constitute contraindications to the use of Ibuprom.
Side effects Ibuprom
Side effects of Ibuprom find their imaging in the gastrointestinal tract in the resulting nausea, vomiting, heartburn, in the appearing disorders of the digestive process and stool, in the phenomenon of flatulence, pain in the epigastrium. In isolated cases, gastrointestinal bleeding, duodenal ulcers and stomach ulcers, ulcerative colitis, pancreatitis were noted. There is also a certain probability of changing the perception of taste buds.
Concerning the activity of the liver, the consequences of using the drug are able to become the development of hepatitis, the increase in hepatic enzyme activity, the failure of liver function.
In the central nervous system Ibuprom can lead to such negative phenomena as the occurrence of headache, dizziness, and a state of excessive drowsiness.
The most frequent adverse symptom, observed in the functioning of the cardiovascular system, is an increase in the rhythm of cardiac contractions, tachycardia. In those patients who had a hypersensitivity to Ibuprom, and in addition, when other non-steroidal anti-inflammatory drugs were taken at the same time, in very rare cases, hypertension developed and the onset of heart failure was noted. The use of this drug is also associated with an increased risk that such arterial thrombotic events as stroke and myocardial infarction may occur.
The hematopoietic system of the body is able to give its response to the use of the drug as the development of anemia, leukopenia, pancytopenia and thrombocytopenia. Treatment courses using this medication, which are very long, are associated with the possibility that agranulocytosis may develop, accompanied by ulceration of the oral mucosa, sore throat, fever and an increased risk of bleeding.
In the urinary system, the following changes occur: an increase in the degree of urea in the blood is observed, and the daily volume of urine decreases. It is very rare to find such a phenomenon associated with the use of Ibuprom as a necrosis of the papillae.
There is the possibility of developing allergic reactions in the form of hives, rashes on the skin, erythema multiforme and epidermal necrosis. There is also the possibility of anaphylactic shock and Quincke's edema.
Other side effects of Ibuprom are manifested in the fact that patients with the presence of any autoimmune diseases can develop aseptic meningitis, with its characteristic symptoms: fever, headache, nausea, vomiting, rigidity of the occipital muscles, impaired ability to navigate in space.
Overdose
Overdose Ibuprom leads to the fact that patients who have been used in excessively high doses, there is nausea, vomiting, dizziness, headache, developing gastralgia, they come in a drowsy, lethargic state.
As a consequence of increasing doses of this drug in the future - hypotension may develop, the development of hyperkalemia. This is accompanied by fever, the phenomenon of arrhythmia, the patient can lose consciousness, metabolic acidosis develops, renal function and respiratory processes are disrupted, coma comes.
The chronic nature of intoxication under the influence of the drug used irregularly, but at high doses over a long period of time, as noted, provoked hemolytic anemia, thrombocytopenia, granulocytopenia.
Due to the fact that a specific antidote is unknown, and because of the high degree of binding to proteins in the blood plasma, hemodialysis seems ineffective, as the main therapeutic measures, symptomatic therapy is chosen. The patient is also given enterosorbents and the stomach is washed.
When acute drug poisoning can not discount the possibility that it will lead to metabolic acidosis. Therefore, it is very important to carry out careful monitoring of the patient's condition and, as soon as the first symptoms are revealed, start activities aimed at restoring the acid-base pH balance to 7.0-7.5 and stabilizing its level within this framework.
Until all the symptoms caused by an overdose are eliminated, it is required to keep the body functions that are of vital importance under control. As it is by means of electrocardiography and monitoring of the level of arterial pressure. In addition, not the last role in this regard is given to preventing violations in the central nervous system and the possibility of bleeding of the gastrointestinal tract.
Interactions with other drugs
Given the nature of the interaction of Ibuprom with other drugs, its use in conjunction with other anti-inflammatory drugs of the nonsteroid group requires caution, since in this case there is an increased risk that all sorts of side effects will occur in the hemopoietic system and in the gastrointestinal tract.
On the other hand, Ibuprom is permissible in conjunction with any of those anti-inflammatory non-steroid drugs that differ in a low degree of systemic action.
Glucocorticosteroids are not given concomitantly with this drug, because of the possibility of mutual strengthening of each of them with toxic properties.
Angiotensin-converting enzyme inhibitors and beta-blockers, as well as other antihypertensives, interacting with ibuprofen tend to decrease the degree of their effect.
The use of anticoagulants together with Ibuprom causes the need for regular monitoring of blood coagulation indicators, because platelet aggregation is reduced from ibuprofen.
The effectiveness of the use of diuretics in combination with this drug is reduced. Exposed to such effects, for example, thiazide and loop diuretics.
The joint appointment together with Ibuprom of lithium preparations requires the control of the blood condition for the content of this element, since it helps to increase the concentration of the latter.
The drug is not assigned to those patients who undergo combination antiretroviral therapy for HIV, in which zidovudine is used.
Interactions Ibuprom with other drugs, which, finally, need to be said for a drug such as methotrexate, are characterized by an increase in its, methotrexate, toxicity.
Special instructions
The key feature of the mechanism of action of this medication is as follows: under its influence there is a disruption of the metabolism of arachidonic acid, as a result of the inhibition of the activity of the enzyme cyclooxygenase catalyzing processes characterized by the synthesis of endogenous biologically active substances from arachidonic acid. In particular, the drug acts as an inhibitor for the synthesis of prostaglandins E, F and thromboxane. As a result of its use, prostaglandins tend to tend to reduce their number in the tissues of the central nervous system and in the localization of the focus of the inflammatory process.
This drug is characterized in that it inhibits cyclooxygenase in a non-selective manner, the inhibition of its activity equally affects both isoforms taken by this enzyme-cyclooxygenase-1 and cyclooxygenase-2. Since prostaglandins reduce their presence, receptors become less sensitive to the effects of chemical irritants in the part of the organism that has become inflamed. Inhibition of prostaglandins synthesized in tissues in the central nervous system causes a systemic analgesic effect. Providing the effect that the synthesis of prostaglandins is inhibited in that part of the hypothalamus, which is responsible for the thermoregulation of the body, the drug used for fever, demonstrates its antipyretic properties.
Inhibition is also the synthesis of arachidonic acid thromboxane, which leads to an antiaggregant effect.
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Attention!
To simplify the perception of information, this instruction for use of the drug "Ibuprom" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.