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Ibuprex soft forte

, medical expert
Last reviewed: 09.08.2022
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Ibuprex soft forte is part of the pharmacotherapeutic group of non-steroidal anti-inflammatory drugs (NSAIDs), in particular, derivatives of propionic (methylacetic) acid.

Indications Ibuprex soft forte

Indications for use Ibuprex soft forte are associated with its anti-inflammatory, analgesic and antipyretic properties and include symptomatic treatment of headache and toothache; pain during menstruation; febrile states; rheumatic and neuralgic pain, as well as joint and muscle pain in all parts of the musculoskeletal system.

Release form

The form of the preparation is brown tablets coated with a film membrane; each tablet contains 200 mg of ibuprofen. Other trade names Ibuprex soft forte: Ibuprofen, Bonifen, Brufen, Burana, Dolgit, Ibupron, Ibuprof, Ibusan, Ipren, Markofen, Motrin, Nurofen, Profen, etc.

Pharmacodynamics

Pharmacodynamics Ibuprex soft forte is based on the ability of the active substance - isobutylphenyl-propionic acid - to inactivate the enzyme cyclooxygenase (COX) and thus inhibit the synthesis of mediators of pain, inflammation and temperature reaction (prostaglandins).

In addition, like all non-steroidal anti-inflammatory drugs, the drug Iprex Soft forte blocks cyclooxygenase activity of platelets, improving blood flow in the area of inflammation and preventing the formation of thrombi.

Pharmacokinetics

Getting into the stomach after ingestion, Ibuprex soft forte quickly penetrates into the blood by absorption from the gastrointestinal tract. After 1-2 hours after taking the drug reaches the maximum concentration in the blood plasma and after 3 hours - in the synovial fluid. Biological transformation Ibuprex soft forte occurs in the liver; metabolites are excreted by the kidneys; The time of elimination of half of the macromolecular compounds formed as a result of the drug's metabolism is approximately 120 minutes. Unchanged, only 1% of the drug is excreted.

Dosing and administration

The drug Ibuprex soft forte is recommended to use in the treatment of adults in dosage: single dose - 1-2 tablets (200-400 mg) three times a day; the maximum daily dose is 6 tablets (1.2 g). Tablets are taken whole, before meals, washed down with water.

Use Ibuprex soft forte during pregnancy

The use of ibuprex soft during pregnancy is possible only according to the doctor's prescription, when the benefit to the mother greatly exceeds the potential risk to the fetus. But in the first and second trimesters of pregnancy, Ibuprex soft forte (and other non-steroidal anti-inflammatory drugs) is not recommended because of the increased risk of fetal heart disease (premature closure of the ductus arteriosus).

Contraindications

There are the following contraindications to the use of Ibuprex soft forte:

  • increased individual sensitivity to the drug and aspirin resistance;
  • acute stage of stomach and duodenum ulcers;
  • the presence of a history of gastric bleeding, ulcerative colitis, or Crohn's disease;
  • acute renal, cardiac or hepatic insufficiency;
  • age up to 12 years.

Side effects Ibuprex soft forte

Possible side effects Ibuprex soft forte are expressed in the form of headache, gastrointestinal disorders (abdominal pain, nausea, dyspepsia), rashes on the skin and itching of the skin, tachycardia, arterial hypotension.

In patients with autoimmune diseases (systemic lupus erythematosus, rheumatoid arthritis), symptoms of aseptic meningitis can be observed in the treatment of ibuprex soft forte: headache, nausea, vomiting, fever. In the presence of bronchial asthma or other types of allergies, spasm of the bronchi is possible, and with arterial hypertension or heart failure - the appearance of edema.

It should be borne in mind that a long and uncontrolled reception causes such side effects Ibuprex soft forte, like chronic kidney damage with the risk of kidney failure, the risk of stroke or myocardial infarction, and in women of childbearing age - the violation of ovulation.

Overdose

An overdose of this drug causes pain in the area of the stomach, nausea and vomiting, drowsiness, headache, tinnitus, acute kidney failure, falling blood pressure, cardiac arrhythmias, atrial fibrillation, respiratory arrest.

For the treatment of overdose, urgent rinsing of the stomach, intake of activated carbon inside, alkaline drink and diuretics (to increase diuresis) are used.

Interactions with other drugs

The main interactions of Ibuprex soft forte with other drugs are that it should not be taken concurrently with aspirin (acetylsalicylic acid) or other drugs of the group of non-steroidal anti-inflammatory drugs (NSAIDs).

In addition, ibuprex soft forte reduces the effectiveness of drugs used to treat hypertension, as well as all diuretics. Parallel use with anticoagulant drugs increases their antiplatelet activity; with cardiac glycosides - aggravates heart failure; with immunosuppressive drug cyclosporine - increases the degree of negative effects on the kidneys; with lithium and methotrexate - significantly increases their levels in blood plasma; with the antibiotics of the quinolone group - increases the likelihood of seizures.

Storage conditions

Storage conditions Ibuprex soft forte: at temperatures up to + 28 ° C, out of reach of children.

Shelf life

Shelf life - 3 years.

Attention!

To simplify the perception of information, this instruction for use of the drug "Ibuprex soft forte" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.

Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.

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