Humalog

Humalog has a hypoglycemic effect.

[1]

Indications Humalog

It is used for the treatment of diabetes mellitus of an insulin-dependent nature: with poor tolerance to other insulin drugs, postprandial glycemia, which cannot be corrected by other medicines, and in addition, with an acute form of insulin resistance.

It is also used in diabetes mellitus, which has an insulin-independent nature: in the presence of resistance to hypoglycemic agents, as well as in diseases or operations that complicate the clinic of diabetes.

[2],

Release form

The release of the drug is made in the form of injection fluid, inside a cartridge with a capacity of 3 ml, 5 pieces inside the box. Also sold in cartridges (3 ml), packaged in a syringe pen, 5 pieces per package. In addition, it can be produced in bottles of 10 ml (1 bottle in the box).

Pharmacodynamics

Humalog is a DNA modified insulin analog produced by the human body. He is distinguished by the fact that he is able to change the amino acid combination within the insulin B-chain.

The drug regulates glucose metabolism and has an anabolic effect. After its introduction into human muscle tissue, glycogen and glycerol with fatty acids increase, protein synthesis is potentiated and amino acid consumption increases. But along with this, there is a decrease in ketogenesis, gluconeogenesis with lipolysis and glycogenolysis, and in addition, protein catabolism and release of amino acids are weakened.

If a patient has type 1 or type 2 diabetes, in the case of drug administration after a meal, there is more pronounced hyperglycemia in relation to the effects of human insulin. The period of development of the effect of drugs varies in a wide range, and also depends on a large number of factors - portion size, temperature, blood supply, injection area, as well as human physical activity.

The use of medication leads to a decrease in the number of episodes of hypoglycemia occurring at night in diabetics. Its effect in comparison with human insulin develops more quickly (after 15 minutes on average), while the duration of action is shorter (within 2-5 hours).

[3]

Pharmacokinetics

The administered drug is rapidly absorbed, reaching Cmax blood counts after 0.5-1 hour. In people with renal impairment, there is a higher rate of absorption compared to human insulin. Half-life is approximately 60 minutes.

[4], [5], [6], [7]

Dosing and administration

The size of the dose of drugs is selected for each patient separately, taking into account its sensitivity to exogenous insulin, as well as health status. The drug should be administered at least 15 minutes before eating (or after). The mode of the procedure is individual. It should be borne in mind that the temperature of the medication should be at room temperature.

Daily demand can vary significantly, often amounting to 0.5–1 IU / kg. Further, single and daily portions of drugs are adjusted taking into account the patient's metabolic processes and the indications of reusable urine and blood tests for sugar.

Intravenous administration of Humalog is carried out in the form of a standard intravenous injection. Subcutaneous injections are performed in the buttocks, abdomen, shoulders, or thighs; places need to be changed periodically in order not to use one section more often than once in a month. The zone of the introduction of drugs is not required to massage. Perform the procedure very carefully to prevent the penetration of the drug into the blood vessel.

The patient must learn to properly perform the injection.

[10], [11], [12]

Use Humalog during pregnancy

There is a wealth of information regarding the use of the drug during pregnancy There was no development of any negative symptoms associated with the course of pregnancy or the condition of the fetus / newborn. The condition of women with diabetes of insulin-dependent nature or with gestational diabetes using insulin during pregnancy should be closely monitored.

The need for insulin is often reduced in the first trimester, and then increased in the second and third trimesters. Women with diabetes should consult a doctor about conception planning or during pregnancy. During this period, these patients should be under constant observation - in order to monitor blood sugar indicators and general condition.

Nursing mothers with diabetes may need to adjust the dosage of the drug or diet.

Contraindications

Main contraindications:

• the presence of high sensitivity regarding the drug;
• gypoglycemia.

[8], [9]

Side effects Humalog

The main adverse event provoked by the influence of drugs is hypoglycemia. With a severe degree of this pathology, loss of consciousness (due to hypoglycemic coma) can occur, and besides this, even death can occur.

Signs of allergies: mainly in the form of local symptoms - redness, swelling, itching or lipodystrophy at the site of the injection. More rarely observed systemic manifestations of allergy - fever, pruritus, dyspnea, low blood pressure, angioedema, tachycardia and hyperhidrosis.

Overdose

In case of overdose with medication, hypoglycemia may develop, against which hyperhidrosis, tremors, a feeling of lethargy, tachycardia, and also apathy, headaches, vomiting and disorder of consciousness are observed. It should be borne in mind that hypoglycemia can occur not only in connection with drug intoxication, but also as a result of enhanced insulin activity, provoked by the use of food or energy consumption.

Given the severity of hypoglycemia, appropriate procedures are performed.

[13], [14]

Interactions with other drugs

The antidiabetic activity of drugs is weakened when combined with thyroid hormones, oral contraception, danazol, and GCS. In addition, this list includes tricyclics, chlorprothixen, β2-adrenomimetics, diazoxide with diuretic drugs, lithium carbonate with isoniazid, niacin, and phenothiazine derivatives.

The antidiabetic properties of Humalog are potentiated when combined with substances containing ethyl alcohol, β-adrenergic blockers, MAOIs, anabolic steroids, fenfluramine, and in addition with salicylates, tetracyclines, ACE inhibitors, guanethidine, octreotide, sulfanilamides, and hypochymes, and hypochromicates, and hypochromicomas, as well as hypogrammes, and hypochromia, and hypochromicomas.

It is forbidden to mix the medicine with animal insulin substances, although it can be used under medical supervision with human insulin (prolonged type of exposure).

[15], [16]

Storage conditions

Humalog can not be frozen. The drug should be kept at a temperature range of 2-8 ° C.

[17],

Shelf life

Humalog can be used within 24 months from the moment the pharmaceutical product is manufactured.

[18]

Application for children

It is more preferable to use Humalog in children than soluble human insulin only in situations where the rapid effect exerted by insulin is considered an important advantage — for example, if the time of injection is chosen relative to food intake.

[19], [20], [21], [22]

Analogs

Analogues of drugs are the means Farmassulin, Inutral SPP, as well as Inutral HM, and in addition Iletin II regular with Iletin I regular.

[23], [24], [25]

Reviews

Humalog often receives positive reviews - the drug qualitatively compensates for the deficiency of glucose in the blood. The development of negative symptoms is quite rare.