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Horagon
Last reviewed: 04.07.2025
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Choragon is human chorionic gonadotropin.
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Indications Choragon
It is used in the following conditions:
- eunuchoidism or cryptorchidism;
- oligoasthenospermia;
- genital infantilism;
- testicular hypoplasia;
- dwarfism;
- hypogenitalism;
- adiposogenital dystrophy;
- the presence of a threat of spontaneous abortion;
- dysmenorrhea;
- habitual miscarriage;
- ovarian hyperstimulation using ART;
- corpus luteum deficiency;
- anovulation-induced infertility;
- gonadal hypofunction in women or men caused by dysfunction of the HPS.
Release form
The drug is released in the form of a lyophilisate, dissolved for parenteral injections. The pack contains 3 ampoules with powder.
Pharmacodynamics
The active ingredient of the drug is a naturally occurring chorionic gonadotropin secreted from the urine of a pregnant woman. After obtaining this component, it must be sterilized and purified. Its properties are similar to those of lutropin secreted by the anterior pituitary lobe, but it differs in that it has a higher efficiency (due to a longer half-life).
In male patients, the drug stimulates the production of sex steroids (such as testosterone with estradiol, as well as 2-hydrotestosterone and 170H-progesterone) and spermatogenesis processes. In female patients, ovulation and estrogen and progesterone binding processes are stimulated. This drug increases blood cholesterol levels.
Pharmacokinetics
Blood Cmax values of the substance are noted after 4-12 hours from the moment of injection. The half-life is about 29-30 hours, due to which, with daily injections, accumulation of the drug may occur. Excretion is performed through the kidneys.
Dosing and administration
The resulting solution of the drug must be immediately administered to the patient via intramuscular injection.
Boys and adult men, in case of differential diagnosis of cryptorchidism, as well as anorchia, require a single administration of 5000 IU of the drug.
In case of hypogonadism of a hypogonadotropic nature, it is necessary to use within 1500-6000 IU of the substance once a week, combining it with medications that contain natural menopausal gonadotropins.
To speed up the process of puberty, 1500 IU of the drug should be used 2-3 times a week for a period of 90 days.
For boys aged 2-6 years, 500-2000 IU of Choragon are administered weekly for 5 weeks to treat cryptorchidism. For children aged 3-6 years, 1500 IU of the drug should be used once a week for 21 days.
Women need to administer 1500-5000 IU of the drug on the 3rd, 6th and 9th days after ovulation to maintain the activity of the corpus luteum of the ovaries. To induce ovulation directly, 5000 or 10000 IU of the drug is used.
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Use Choragon during pregnancy
There is no need to prescribe the medication during normal pregnancy or lactation.
Contraindications
Among the contraindications:
- adrenal insufficiency;
- bleeding of a gynecological nature, developing for an unknown reason;
- the presence of cysts in the ovarian area that are not associated with polycystic disease;
- a history of ectopic pregnancy (within the previous 3 months);
- cryptorchidism caused by inguinal hernia;
- hypothyroidism;
- active thromboembolic disorders;
- early menopause;
- gonadal dysgenesis;
- neoplasms in the pituitary gland;
- thrombophlebitis;
- blockage of the fallopian tubes;
- hyperprolactinemia;
- the presence of neoplasms dependent on androgen levels;
- the presence of intolerance to human chorionic gonadotropin and mannitol;
- ovarian carcinoma.
Side effects Choragon
The use of the medication may lead to the following side effects:
- formation of antibodies against human chorionic gonadotropin (with prolonged use of the drug);
- changes in behavior;
- hives, acne, swelling;
- allergy symptoms that are generalized;
- gynecomastia;
- inhibition of the synthetic activity of the pituitary gland;
- erection;
- state of depression;
- increase in the size of the testicles;
- increased sensitivity of nipples;
- a feeling of intense irritability or anxiety;
- asthenia or headaches;
- local pain after injection;
- local hyperemia.
Overdose
Overdose may cause ovarian hyperstimulation.
Therapeutic procedures are determined by the severity of the pathology. At stage 2 or 3 of the disease, mandatory hospitalization is required.
Storage conditions
Choragon must be kept at a temperature of maximum 20°C. The dissolved medicine must be used immediately; it must not be stored.
Shelf life
Choragon can be used within 36 months from the date of release of the pharmaceutical product.
Application for children
Choragon is prescribed to boys for the treatment of cryptorchidism - it should be started after six months from the date of birth.
Analogues
Analogues of the drug are Profazi, Ovitrelle, Pregnyl and Human Chorionic Gonadotropin.
Reviews
Choragon is considered a fairly popular drug, especially among women. Reviews indicate that it has a fairly high therapeutic effectiveness.
Attention!
To simplify the perception of information, this instruction for use of the drug "Horagon" translated and presented in a special form on the basis of the official instructions for medical use of the drug. Before use read the annotation that came directly to medicines.
Description provided for informational purposes and is not a guide to self-healing. The need for this drug, the purpose of the treatment regimen, methods and dose of the drug is determined solely by the attending physician. Self-medication is dangerous for your health.